Stein JD, Khawaja AP, Weizer JS (2021) Glaucoma in adults-screening, diagnosis, and management: a review. JAMA 325:164–174

Article  PubMed  Google Scholar 

Weinreb RN, Leung CK, Crowston JG, Medeiros FA, Friedman DS, Wiggs JL et al (2016) Primary open-angle glaucoma. Nat Rev Dis Primers 2:16067

Article  PubMed  Google Scholar 

Fricke TR, Tahhan N, Resnikoff S, Papas E, Burnett A, Ho SM et al (2018) Global prevalence of presbyopia and vision impairment from uncorrected presbyopia: systematic review, meta-analysis, and modelling. Ophthalmology 125:1492–1499

Article  PubMed  Google Scholar 

Bussel II, Wollstein G, Schuman JS (2014) OCT for glaucoma diagnosis, screening and detection of glaucoma progression. Br J Ophthalmol 98(Suppl 2):ii15–ii19

Article  PubMed  Google Scholar 

He L, Hannon GJ (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5:522–531

Article  CAS  PubMed  Google Scholar 

Tan C, Song M, Stamer WD, Qiao Y, Chen X, Sun X et al (2020) miR-21-5p: a viable therapeutic strategy for regulating intraocular pressure. Exp Eye Res 200:108197

Article  CAS  PubMed  Google Scholar 

Tan C, Jia F, Zhang P, Sun X, Qiao Y, Chen X et al (2021) A miRNA stabilizing polydopamine nano-platform for intraocular delivery of miR-21-5p in glaucoma therapy. J Mater Chem B 9:3335–3345

Article  CAS  PubMed  Google Scholar 

Luna C, Li G, Qiu J, Epstein DL, Gonzalez P (2011) MicroRNA-24 regulates the processing of latent TGFbeta1 during cyclic mechanical stress in human trabecular meshwork cells through direct targeting of FURIN. J Cell Physiol 226:1407–1414

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smyth A, Callaghan B, Willoughby CE, O’Brien C (2022) The role of miR-29 family in TGF-beta driven fibrosis in glaucomatous optic neuropathy. Int J Mol Sci 23(18):10216

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li N, Cui J, Duan X, Chen H, Fan F (2012) Suppression of type I collagen expression by miR-29b via PI3K, Akt, and Sp1 pathway in human Tenon’s fibroblasts. Investig Ophthalmol Vis Sci 53:1670–1678

Article  CAS  Google Scholar 

Cortez MA, Bueso-Ramos C, Ferdin J, Lopez-Berestein G, Sood AK, Calin GA (2011) MicroRNAs in body fluids—the mix of hormones and biomarkers. Nat Rev Clin Oncol 8:467–477

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Chen Y, Wang Y, Zhang X, Gao K, Chen S et al (2018) microRNA profiling in glaucoma eyes with varying degrees of optic neuropathy by using next-generation sequencing. Investig Ophthalmol Vis Sci 59:2955–2966

Article  CAS  Google Scholar 

Hindle AG, Thoonen R, Jasien JV, Grange RMH, Amin K, Wise J et al (2019) Identification of candidate miRNA biomarkers for glaucoma. Investig Ophthalmol Vis Sci 60:134–146

Article  CAS  Google Scholar 

Liu Y, Wang Y, Chen Y, Fang X, Wen T, Xiao M et al (2019) Discovery and validation of circulating Hsa-miR-210-3p as a potential biomarker for primary open-angle glaucoma. Investig Ophthalmol Vis Sci 60:2925–2934

Article  CAS  Google Scholar 

Kosior-Jarecka E, Czop M, Gasinska K, Wrobel-Dudzinska D, Zalewski DP, Bogucka-Kocka A et al (2021) MicroRNAs in the aqueous humor of patients with different types of glaucoma. Graefes Arch Clin Exp Ophthalmol 259:2337–2349

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hubens WHG, Krauskopf J, Beckers HJM, Kleinjans JCS, Webers CAB, Gorgels T (2021) Small RNA sequencing of aqueous humor and plasma in patients with primary open-angle glaucoma. Investig Ophthalmol Vis Sci 62:24

Article  CAS  Google Scholar 

Martinez B, Peplow PV (2022) MicroRNAs as biomarkers in glaucoma and potential therapeutic targets. Neural Regen Res 17:2368–2375

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, Gibson DF et al (2011) Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A 108:5003–5008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turchinovich A, Burwinkel B (2012) Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma. RNA Biol 9:1066–1075

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji C, Guo X (2019) The clinical potential of circulating microRNAs in obesity. Nat Rev Endocrinol 15:731–743

Article  CAS  PubMed  Google Scholar 

Lei Y, Overby DR, Read AT, Stamer WD, Ethier CR (2010) A new method for selection of angular aqueous plexus cells from porcine eyes: a model for Schlemm’s canal endothelium. Investig Ophthalmol Vis Sci 51:5744–5750

Article  Google Scholar 

Grunkemeier GL, Jin R (2015) Net reclassification index: measuring the incremental value of adding a new risk factor to an existing risk model. Ann Thorac Surg 99:388–392

Article  PubMed  Google Scholar 

Fiedorowicz E, Cieslinska A, Kuklo P, Grzybowski A (2021) Protein biomarkers in glaucoma: a review. J Clin Med 10(22):5388

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Hou XW, Liang G, Pan CW (2021) Metabolomics in glaucoma: a systematic review. Investig Ophthalmol Vis Sci 62:9

Article  CAS  Google Scholar 

Zhao M, Ma P, Xie Q, Bui AD, Yonamine S, Hinterwirth A et al (2022) Biomarkers for primary open-angle glaucoma progression. Exp Eye Res 219:109025

Article  CAS  PubMed  Google Scholar 

Wang L, Yu T, Zhang X, Cai X, Sun H (2021) Network integration analysis and immune infiltration analysis reveal potential biomarkers for primary open-angle glaucoma. Front Cell Dev Biol 9:793638

Article  PubMed  PubMed Central  Google Scholar 

Myer C, Perez J, Abdelrahman L, Mendez R, Khattri RB, Junk AK et al (2020) Differentiation of soluble aqueous humor metabolites in primary open angle glaucoma and controls. Exp Eye Res 194:108024

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leruez S, Marill A, Bresson T, de Saint MG, Buisset A, Muller J et al (2018) A metabolomics profiling of glaucoma points to mitochondrial dysfunction, senescence, and polyamines deficiency. Investig Ophthalmol Vis Sci 59:4355–4361

Article  CAS  Google Scholar 

Kouassi Nzoughet J, Guehlouz K, Leruez S, Gohier P, Bocca C, Muller J et al (2020) A data mining metabolomics exploration of glaucoma. Metabolites 10(2):49

Article  PubMed  PubMed Central  Google Scholar 

Wu J, Xu M, Liu W, Huang Y, Wang R, Chen W et al (2022) Glaucoma characterization by machine learning of tear metabolic fingerprinting. Small Methods 6:e2200264

Article  PubMed  Google Scholar 

Luna C, Li G, Qiu J, Epstein DL, Gonzalez P (2009) Role of miR-29b on the regulation of the extracellular matrix in human trabecular meshwork cells under chronic oxidative stress. Mol Vis 15:2488–2497

CAS  PubMed  PubMed Central  Google Scholar 

Parker VA, Herrtage J, Sarkies NJ (2001) Clinical comparison of the Keeler Pulsair 3000 with Goldmann applanation tonometry. Br J Ophthalmol 85:1303–1304

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jorge J, Díaz-Rey JA, González-Méijome JM, Almeida JB, Parafita MA (2002) Clinical performance of the Reichert AT550: a new non-contact tonometer. Ophthalmic Physiol Opt J Br Coll Ophthalmic Opt Optom 22:560–564

Article  CAS  Google Scholar 

Jorge J, González-Méijome JM, Díaz-Rey JA, Almeida JB, Ribeiro P, Parafita MA (2003) Clinical performance of non-contact tonometry by Reichert AT550 in glaucomatous patients. Ophthalmic Physiol Opt J Br Coll Ophthalmic Opt Optom 23:503–506

Article  CAS  Google Scholar