Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49. https://doi.org/10.3322/caac.21660.

Article  CAS  PubMed  Google Scholar 

Yang JD, Heimbach JK. New advances in the diagnosis and management of hepatocellular carcinoma. BMJ. 2020. https://doi.org/10.1136/bmj.m3544.

Article  PubMed  PubMed Central  Google Scholar 

Galle PR, Forner A, Llovet JM, Mazzaferro V, Piscaglia F, Raoul JL, Schirmacher P, Vilgrain V, European Assoc Study L. EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69:182–236.

Article  Google Scholar 

Piscaglia F, Ogasawara S. Patient selection for transarterial chemoembolization in hepatocellular carcinoma: importance of benefit/risk assessment. Liver Cancer. 2018;7:104–19. https://doi.org/10.1159/000485471.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Golfieri R, Bargellini I, Spreafico C, et al. Patients with barcelona clinic liver cancer stages B and C hepatocellular carcinoma: time for a subclassification. Liver Cancer. 2019;8:78–91. https://doi.org/10.1159/000489791.

Article  CAS  PubMed  Google Scholar 

Lee IC, Hung YW, Liu CA, et al. A new ALBI-based model to predict survival after transarterial chemoembolization for BCLC stage B hepatocellular carcinoma. Liver Int. 2019;39:1704–12. https://doi.org/10.1111/liv.14194.

Article  CAS  PubMed  Google Scholar 

Kim JH, Shim JH, Lee HC, et al. New intermediate-stage subclassification for patients with hepatocellular carcinoma treated with transarterial chemoembolization. Liver Int. 2017;37:1861–8. https://doi.org/10.1111/liv.13487.

Article  CAS  PubMed  Google Scholar 

Hung YW, Lee IC, Chi CT, et al. Redefining tumor burden in patients with intermediate-stage hepatocellular carcinoma: the seven-eleven criteria. Liver Cancer. 2021;10:629–40. https://doi.org/10.1159/000517393.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ignacio de Ulíbarri J, González-Madroño A, de Villar NG, et al. CONUT: a tool for controlling nutritional status. First validation in a hospital population. Nutr Hosp. 2005;20:38–45.

PubMed  Google Scholar 

Harimoto N, Yoshizumi T, Inokuchi S, et al. Prognostic significance of preoperative controlling nutritional status (CONUT) score in patients undergoing hepatic resection for hepatocellular carcinoma: a multi-institutional study. Ann Surg Oncol. 2018;25:3316–23. https://doi.org/10.1245/s10434-018-6672-6.

Article  PubMed  Google Scholar 

Kuroda D, Sawayama H, Kurashige J, et al. Controlling nutritional status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection. Gastric Cancer. 2018;21:204–12. https://doi.org/10.1007/s10120-017-0744-3.

Article  PubMed  Google Scholar 

Okamoto S, Ureshino H, Kidoguchi K, et al. Clinical impact of the CONUT score in patients with multiple myeloma. Ann Hematol. 2020;99:113–9. https://doi.org/10.1007/s00277-019-03844-2.

Article  CAS  PubMed  Google Scholar 

Yılmaz A, Tekin SB, Bilici M, et al. The significance of controlling nutritional status (CONUT) score as a novel prognostic parameter in small cell lung cancer. Lung. 2020;198:695–704. https://doi.org/10.1007/s00408-020-00361-2.

Article  CAS  PubMed  Google Scholar 

Lin ZX, Ruan DY, Jia CC, et al. Controlling nutritional status (CONUT) score-based nomogram to predict overall survival of patients with HBV-associated hepatocellular carcinoma after curative hepatectomy. Clin Transl Oncol. 2020;22:370–80. https://doi.org/10.1007/s12094-019-02137-4.

Article  CAS  PubMed  Google Scholar 

Peng W, Yao M, Zou K, et al. Postoperative controlling nutritional status score is an independent risk factor of survival for patients with small hepatocellular carcinoma: a retrospective study. BMC Surg. 2021;21:338. https://doi.org/10.1186/s12893-021-01334-9.

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Zhao C, Yang Y, et al. Using the controlling nutritional status (CONUT) score for evaluating patients with early-stage hepatocellular carcinoma after radiofrequency ablation: a two-center retrospective study. Cardiovasc Intervent Radiol. 2020;43:1294–304. https://doi.org/10.1007/s00270-020-02519-0.

Article  PubMed  Google Scholar 

Müller L, Hahn F, Mähringer-Kunz A, et al. Immunonutritive scoring in patients with hepatocellular carcinoma undergoing transarterial chemoembolization: prognostic nutritional index or controlling nutritional status score? Front Oncol. 2021;11:696183. https://doi.org/10.3389/fonc.2021.696183.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heimbach JK, Kulik LM, Finn RS, et al. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018;67:358–80. https://doi.org/10.1002/hep.29086.

Article  PubMed  Google Scholar 

Tsunematsu M, Haruki K, Fujiwara Y, et al. Preoperative controlling nutritional status (CONUT) score predicts long-term outcomes in patients with non-B non-C hepatocellular carcinoma after curative hepatic resection. Langenbecks Arch Surg. 2021;406:99–107. https://doi.org/10.1007/s00423-020-01987-9.

Article  PubMed  Google Scholar 

Reig M, Forner A, Rimola J, et al. BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update. J Hepatol. 2022;76:681–93. https://doi.org/10.1016/j.jhep.2021.11.018.

Article  PubMed  Google Scholar 

Li SP, Cao D, He JH, et al. High platelet count predicts poor prognosis in HCC patients undergoing TACE: a propensity score-matched analysis. Expert Rev Gastroenterol Hepatol. 2022;16:193–9. https://doi.org/10.1080/17474124.2022.2031977.

Article  CAS  PubMed  Google Scholar 

Ryo S, Kanda M, Ito S, et al. The controlling nutritional status score serves as a predictor of short- and long-term outcomes for patients with stage 2 or 3 gastric cancer: analysis of a multi-institutional data set. Ann Surg Oncol. 2019;26:456–64. https://doi.org/10.1245/s10434-018-07121-w.

Article  PubMed  Google Scholar 

Qian W, Xiao-Jian J, Jun H, et al. Comparison of the value of multiple preoperative objective nutritional indices for the evaluation of prognosis after hepatectomy for hepatocellular carcinoma. Nutr Cancer. 2022;74:3217–27. https://doi.org/10.1080/01635581.2022.2069276.

Article  CAS  PubMed  Google Scholar 

Huang TH, Hsieh CC, Kuo LM, et al. Malnutrition associated with an increased risk of postoperative complications following hepatectomy in patients with hepatocellular carcinoma. HPB (Oxford). 2019;21:1150–5. https://doi.org/10.1016/j.hpb.2019.01.003.

Article  PubMed  Google Scholar 

Loftus TJ, Brown MP, Slish JH, et al. Serum levels of prealbumin and albumin for preoperative risk stratification. Nutr Clin Pract. 2019;34:340–8. https://doi.org/10.1002/ncp.10271.

Article  PubMed  Google Scholar 

Núñez KG, Sandow T, Patel J, et al. Hypoalbuminemia is a hepatocellular carcinoma independent risk factor for tumor progression in low-risk bridge to transplant candidates. Cancers (Basel). 2022. https://doi.org/10.3390/cancers14071684.

Article  PubMed  Google Scholar 

Qu Z, Lu YJ, Feng JW, et al. Preoperative prognostic nutritional index and neutrophil-to-lymphocyte ratio predict survival outcomes of patients with hepatocellular carcinoma after curative resection. Front Oncol. 2021;11:823054. https://doi.org/10.3389/fonc.2021.823054.

Article  CAS  PubMed  Google Scholar 

de Ulíbarri Pérez JI, Fernández G, Rodríguez Salvanés F, et al. Nutritional screening; control of clinical undernutrition with analytical parameters. Nutr Hosp. 2014;29:797–811. https://doi.org/10.3305/nh.2014.29.4.7275.

Article  PubMed  Google Scholar 

Jiang SS, Weng DS, Jiang L, et al. The clinical significance of preoperative serum cholesterol and high-density lipoprotein-cholesterol levels in hepatocellular carcinoma. J Cancer. 2016;7:626–32. https://doi.org/10.7150/jca.13837.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chew V, Tow C, Teo M, et al. Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients. J Hepatol. 2010;52:370–9. https://doi.org/10.1016/j.jhep.2009.07.013.

Article  CAS  PubMed  Google Scholar 

Refolo MG, Messa C, Guerra V, et al. Inflammatory mechanisms of HCC development. Cancers (Basel). 2020. https://doi.org/10.3390/cancers12030641.

Article  PubMed  Google Scholar 

Mano Y, Shirabe K, Yamashita Y, et al. Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis. Ann Surg. 2013;258:301–5. https://doi.org/10.1097/SLA.0b013e318297ad6b.

Article  PubMed  Google Scholar 

Nagai S, Abouljoud MS, Kazimi M, et al. Peritransplant lymphopenia is a novel prognostic factor in recurrence of hepatocellular carcinoma after liver transplantation. Transplantation. 2014;97:694–701. https://doi.org/10.1097/01.TP.0000437426.15890.1d.

Article  PubMed  Google Scholar 

Ding W, Xu X, Qian Y, et al. Prognostic value of tumor-infiltrating lymphocytes in hepatocellular carcinoma: A meta-analysis. Medicine (Baltimore). 2018;97:e13301. https://doi.org/10.1097/md.0000000000013301.

Article  PubMed  Google Scholar 

Takagi K, Yagi T, Umeda Y, et al. Preoperative controlling nutritional status (CONUT) score for assessment of prognosis following hepatectomy for hepatocellular carcinoma. World J Surg. 2017;41:2353–60. https://doi.org/10.1007/s00268-017-3985-8.