Sung H et al (2021) Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660

Article  CAS  PubMed  Google Scholar 

Thavarool SB et al (2019) Improved survival among oral cancer patients: findings from a retrospective study at a tertiary care cancer centre in rural Kerala, India. World J Surg Oncol 17(1):15. https://doi.org/10.1186/s12957-018-1550-z

Article  PubMed  PubMed Central  Google Scholar 

Bernier J et al (2005) Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck 27(10):843–850. https://doi.org/10.1002/hed.20279

Article  PubMed  Google Scholar 

Binmadi NO, Basile JR (2011) Perineural invasion in oral squamous cell carcinoma: a discussion of significance and review of the literature. Oral Oncol 47(11):1005–1010. https://doi.org/10.1016/j.oraloncology.2011.08.002

Article  PubMed  Google Scholar 

Liebig C, Ayala G, Wilks JA, Berger DH, Albo D (2009) Perineural invasion in cancer: a review of the literature. Cancer 115(15):3379–3391. https://doi.org/10.1002/cncr.24396

Article  CAS  PubMed  Google Scholar 

Fagan JJ, Collins B, Barnes L, Myers EN, Johnson JT, Collins P (1998) Perineural invasion in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 124(6):637

Article  CAS  PubMed  Google Scholar 

Nair D et al (2018) Perineural invasion: independent prognostic factor in oral cancer that warrants adjuvant treatment. Head Neck 40(8):1780–1787. https://doi.org/10.1002/hed.25170

Article  PubMed  Google Scholar 

Rajappa SK et al (2019) Oncological benefits of postoperative radiotherapy in node-negative early stage cancer of the oral cavity with isolated perineural invasion. Br J Oral Maxillofac Surg 57(5):454–459. https://doi.org/10.1016/j.bjoms.2019.04.002

Article  CAS  PubMed  Google Scholar 

Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR et al (eds) (2017) AJCC cancer staging manual, 8th edn. Springer International Publishing, American Joint Commission on Cancer, Berlin

Google Scholar 

National comprehensive cancer network. Head and neck cancers (version 2.2024). https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf. Accessed 23 Dec 2023

Rohde M et al (2020) Definition of locally recurrent head and neck squamous cell carcinoma: a systematic review and proposal for the Odense-Birmingham definition. Eur Arch Otorhinolaryngol 277(6):1593–1599. https://doi.org/10.1007/s00405-020-05953-5

Article  PubMed  Google Scholar 

Seethala RR et al. (2017) Protocol for the examination of specimens from patients with carcinomas of the lip and oral cavity. College of American Pathologists. Version: 4.0.0.1. CAP, https://documents.cap.org/protocols/cp-headandneck-lip-oralcavity-17protocol-4001.pdf. Accessed 11 Jan 2022

Li J, Liu S, Li Z, Han X, Que L (2021) Prognostic value of perineural invasion in oral tongue squamous cell carcinoma: a systematic review and meta-analysis. Front Oncol 11:683825. https://doi.org/10.3389/fonc.2021.683825

Article  PubMed  PubMed Central  Google Scholar 

Kim RY, Helman JI, Braun TM, Ward BB (2019) Increased presence of perineural invasion in the tongue and floor of the mouth: could it represent a more aggressive oral squamous cell carcinoma, or do larger aggressive tumors cause perineural invasion? J Oral Maxillofac Surg 77(4):852–858. https://doi.org/10.1016/j.joms.2018.07.023

Article  PubMed  Google Scholar 

Cracchiolo JR et al (2018) Patterns of recurrence in oral tongue cancer with perineural invasion. Head Neck 40(6):1287–1295. https://doi.org/10.1002/hed.25110

Article  PubMed  PubMed Central  Google Scholar 

Quintana DMVO, Dedivitis RA, Kowalski LP (2022) Prognostic impact of perineural invasion in oral cancer: a systematic review. Acta Otorhinolaryngol Ital 42(1):17–25. https://doi.org/10.14639/0392-100X-N1653

Article  PubMed  PubMed Central  Google Scholar 

Festa BM et al (2023) Impact of adjuvant radiotherapy in squamous cell carcinoma of the oral cavity with perineural invasion. Laryngoscope. John Wiley and Sons Inc, Hoboken

Google Scholar 

Sharma K, Ahlawat P, Gairola M, Tandon S, Sachdeva N, Sharief MI (2019) Prognostic factors, failure patterns and survival analysis in patients with resectable oral squamous cell carcinoma of the tongue. Radiat Oncol J 37(2):73–81. https://doi.org/10.3857/roj.2018.00577

Article  PubMed  PubMed Central  Google Scholar 

Chatzistefanou I, Lubek J, Markou K, Ord RA (2017) The role of perineural invasion in treatment decisions for oral cancer patients: a review of the literature. J Cranio-Maxillofac Surg 45(6):821–825. https://doi.org/10.1016/j.jcms.2017.02.022

Article  Google Scholar 

Vonk J et al (2019) Effect of adjuvant radiotherapy on the local recurrence of oral squamous cell carcinoma with perineural invasion: a systematic review. Clin Otolaryngol 44(2):131–137. https://doi.org/10.1111/coa.13239

Article  PubMed  Google Scholar 

Hasmat S et al (2019) Multifocal perineural invasion is a better prognosticator than depth of invasion in oral squamous cell carcinoma. Head Neck 41(11):3992–3999. https://doi.org/10.1002/hed.25940

Article  PubMed  Google Scholar 

Kernohan MD, Clark JR, Gao K, Ebrahimi A, Milross CG (2010) Predicting the prognosis of oral squamous cell carcinoma after first recurrence. Arch Otolaryngol Head Neck Surg 136(12):1235. https://doi.org/10.1001/archoto.2010.214

Article  PubMed  Google Scholar 

Weckx A, Riekert M, Grandoch A, Schick V, Zöller JE, Kreppel M (2019) Time to recurrence and patient survival in recurrent oral squamous cell carcinoma. Oral Oncol 94:8–13. https://doi.org/10.1016/j.oraloncology.2019.05.002

Article  PubMed  Google Scholar 

Park J et al (2020) Prognosis of oral squamous cell carcinoma with perineural invasion: a comparative study of classification types. Clin Otolaryngol 45(1):99–105. https://doi.org/10.1111/coa.13472

Article  PubMed  Google Scholar 

Huang SH et al (2020) The role of adjuvant (chemo-) radiotherapy in oral cancers in the contemporary era. Oral Oncol 102:104563. https://doi.org/10.1016/j.oraloncology.2019.104563

Article  CAS  PubMed  Google Scholar