Gut-brain axis in the pathogenesis of sepsis-associated encephalopathy

Keywords

Gut-brain axis

Sepsis-associated encephalopathy

Vagus nerve

Neuroendocrine

Neuroimmune

AbbreviationsACTH

adrenocorticotropic hormone

AHR

arylhydrocarbon receptor

BDNF

brain-derived neurotrophic factor

CARS

compensatory anti-inflammatory response syndrome

CNS

central nervous system

CRH

corticotropin-releasing hormone

DAMPs

damage-associated molecular patterns

ECCs

enterochromaffin cells

FMT

fecal microbiota transplantation

FXR

nuclear farnesoid X receptors

GM-CSF

granulocyte-macrophage colony-stimulating factor

GPBAR-1

G protein-coupled BA receptor 1

HMGB1

high mobility group box 1

HPA

hypothalamic-pituitary-adrenal

IECs

intestinal epithelial cells

IGF-1

insulin-like growth factor 1

iNOS

inducible nitric oxide synthase

LAMP

lysosomal-associated membrane protein-1

MAMPs

microbial-associated molecular patterns

MMP12

matrix metalloproteinase 12

NADPH

nicotinamide adenine dinucleotide phosphate

NOD

nucleotide-binding oligomerization domain

Nrf2

nuclear factor erythroid factor 2

NTS

nucleus tractus solitaris

PAMPs

pathogen-associated molecular patterns

PMNs

polymorphonuclear leukocytes

PSD95

postsynaptic density-95

ROS

reactive oxygen species

SAE

sepsis-associated encephalopathy

SCFAs

short-chain fatty acids

SDV

subdiaphragmatic vagotomy

TNF-α

tumor necrosis factor-alpha

TRAIL

TNF-related apoptosis-inducing ligand

TRIF

Toll-interleukin-1 receptor (TIR)-domain-containing adaptor-inducing IFN-beta

VEGF

vascular endothelial growth factor

γ-GABA

γ-aminobutyric acid

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