Pathway-based signatures predict patient outcome, chemotherapy benefit and synthetic lethal dependencies in invasive lobular breast cancer

McCart Reed AE, Kutasovic JR, Lakhani SR, Simpson PT. Invasive lobular carcinoma of the breast: morphology, biomarkers and ‘omics. Breast Cancer Res. 2015;17:12.

Article  PubMed  Google Scholar 

McCart Reed AE, Kalinowski L, Simpson PT, Lakhani SR. Invasive lobular carcinoma of the breast: the increasing importance of this special subtype. Breast Cancer Res. 2021;23:6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sflomos G, Schipper K, Koorman T, Fitzpatrick A, Oesterreich S, Lee AV, et al. Atlas of lobular breast cancer models: challenges and strategic directions. Cancers. 2021;13:5396.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wilson N, Ironside A, Diana A, Oikonomidou O. Lobular breast cancer: a review. Front Oncol. 2020;10:591399.

Article  PubMed  Google Scholar 

Ciriello G, Gatza ML, Beck AH, Wilkerson MD, Rhie SK, Pastore A, et al. Comprehensive molecular portraits of invasive lobular breast cancer. Cell. 2015;163:506–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pestalozzi BC, Zahrieh D, Mallon E, Gusterson BA, Price KN, Gelber RD, et al. Distinct clinical and prognostic features of infiltrating lobular carcinoma of the breast: combined results of 15 International Breast Cancer Study Group clinical trials. J Clin Oncol. 2008;26:3006–14.

Article  PubMed  Google Scholar 

Mathew A, Rajagopal PS, Villgran V, Sandhu GS, Jankowitz RC, Jacob M, et al. Distinct pattern of metastases in patients with invasive lobular carcinoma of the breast. Geburtshilfe Frauenheilkd. 2017;77:660–6.

Article  PubMed  PubMed Central  Google Scholar 

Oesterreich S, Nasrazadani A, Zou J, Carleton N, Onger T, Wright MD, et al. Clinicopathological features and outcomes comparing patients with invasive ductal and lobular breast cancer. J Natl Cancer Inst. 2022;114:1511–22.

Article  PubMed  PubMed Central  Google Scholar 

McCart Reed AE, Lal S, Kutasovic JR, Wockner L, Robertson A, de Luca XM, et al. LobSig is a multigene predictor of outcome in invasive lobular carcinoma. NPJ Breast Cancer. 2019;5:18.

Article  PubMed  PubMed Central  Google Scholar 

Desmedt C, Zoppoli G, Gundem G, Pruneri G, Larsimont D, Fornili M, et al. Genomic characterization of primary invasive lobular breast cancer. J Clin Oncol. 2016;34:1872–81.

Article  CAS  PubMed  Google Scholar 

Sikora MJ, Jacobsen BM, Levine K, Chen J, Davidson NE, Lee AV, et al. WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines. Breast Cancer Res. 2016;18:92.

Article  PubMed  PubMed Central  Google Scholar 

Riggins RB, Lan JP, Zhu Y, Klimach U, Zwart A, Cavalli LR, et al. ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancer. Cancer Res. 2008;68:8908–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luveta J, Parks RM, Heery DM, Cheung KL, Johnston SJ. Invasive lobular breast cancer as a distinct disease: implications for therapeutic strategy. Oncol Ther. 2020;8:1–11.

Article  PubMed  Google Scholar 

Wishart GC, Azzato EM, Greenberg DC, Rashbass J, Kearins O, Lawrence G, et al. PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer. Breast Cancer Res. 2010;12:R1.

Article  PubMed  PubMed Central  Google Scholar 

Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med. 2004;351:2817–26.

Article  CAS  PubMed  Google Scholar 

Timbres J, Moss C, Mera A, Haire A, Gillett C, Van Hemelrijck M, et al. Survival outcomes in invasive lobular carcinoma compared to oestrogen receptor-positive invasive ductal carcinoma. Cancers. 2021;13:3036.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guiu S, Wolfer A, Jacot W, Fumoleau P, Romieu G, Bonnetain F, et al. Invasive lobular breast cancer and its variants: how special are they for systemic therapy decisions? Crit Rev Oncol Hematol. 2014;92:235–57.

Article  PubMed  Google Scholar 

Beumer IJ, Persoon M, Witteveen A, Dreezen C, Chin SF, Sammut SJ, et al. Prognostic value of MammaPrint((R)) in invasive lobular breast cancer. Biomark Insights. 2016;11:139–46.

Article  PubMed  PubMed Central  Google Scholar 

Metzger-Filho O, Michiels S, Bertucci F, Catteau A, Salgado R, Galant C, et al. Genomic grade adds prognostic value in invasive lobular carcinoma. Ann Oncol. 2013;24:377–84.

Article  CAS  PubMed  Google Scholar 

Christgen M, Gluz O, Harbeck N, Kates RE, Raap M, Christgen H, et al. Differential impact of prognostic parameters in hormone receptor-positive lobular breast cancer. Cancer. 2020;126:4847–58.

Article  CAS  PubMed  Google Scholar 

Filipits M, Rudas M, Jakesz R, Dubsky P, Fitzal F, Singer CF, et al. A new molecular predictor of distant recurrence in ER-positive, HER2-negative breast cancer adds independent information to conventional clinical risk factors. Clin Cancer Res. 2011;17:6012–20.

Article  CAS  PubMed  Google Scholar 

Parker JS, Mullins M, Cheang MC, Leung S, Voduc D, Vickery T, et al. Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol. 2009;27:1160–7.

Article  PubMed  PubMed Central  Google Scholar 

Michaut M, Chin SF, Majewski I, Severson TM, Bismeijer T, de Koning L, et al. Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer. Sci Rep. 2016;6:18517.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ben-Hamo R, Jacob Berger A, Gavert N, Miller M, Pines G, Oren R, et al. Predicting and affecting response to cancer therapy based on pathway-level biomarkers. Nat Commun. 2020;11:3296.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Creixell P, Reimand J, Haider S, Wu G, Shibata T, Vazquez M, et al. Pathway and network analysis of cancer genomes. Nat Methods. 2015;12:615–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haider S, Yao CQ, Sabine VS, Grzadkowski M, Stimper V, Starmans MHW, et al. Pathway-based subnetworks enable cross-disease biomarker discovery. Nat Commun. 2018;9:4746.

Article  PubMed  PubMed Central  Google Scholar 

Brueffer C, Vallon-Christersson J, Grabau D, Ehinger A, Hakkinen J, Hegardt C, et al. Clinical value of RNA sequencing-based classifiers for prediction of the five conventional breast cancer biomarkers: a report from the Population-Based Multicenter Sweden Cancerome Analysis Network-Breast Initiative. JCO Precis Oncol. 2018;2:PO.17.00135.

PubMed  PubMed Central  Google Scholar 

Brueffer C, Gladchuk S, Winter C, Vallon-Christersson J, Hegardt C, Hakkinen J, et al. The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome. EMBO Mol Med. 2020;12:e12118.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schemper M, Smith TL. A note on quantifying follow-up in studies of failure time. Control Clin Trials. 1996;17:343–6.

Article  CAS  PubMed  Google Scholar 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43:e47.

Article  PubMed  PubMed Central  Google Scholar 

Haider S, McIntyre A, van Stiphout RGPM, Winchester LM, Wigfield S, Harris AL, et al. Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia. Genome Biol. 2016;17:140.

Article  PubMed  PubMed Central  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102:15545–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vijaymeena MK, Kavitha K. A survey on similarity measures in text mining. Mach Learn Appl. 2016;3:19–28.

Google Scholar 

Rousseeuw PJ. Silhouettes: a graphical aid to the interpretation and validation of cluster analysis. J Comput Appl Math. 1987;20:53–65.

Article  Google Scholar 

Maechler M, Rousseeuw P, Struyf A, Hubert M, Hornik K. cluster: cluster analysis basics and extensions. R package version 2.0.3. 2015.

Gendoo DM, Ratanasirigulchai N, Schroder MS, Pare L, Parker JS, Prat A, et al. Genefu: an R/Bioconductor package for computation of gene expression-based signatures in breast cancer. Bioinformatics. 2016;32:1097–9.

Article  CAS  PubMed  Google Scholar 

Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature. 2012;486:346–52.

Article  CAS  PubMed 

留言 (0)

沒有登入
gif