Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy
Keywords
Aminoacyl-tRNA synthetase (ARS)
Charcot-Marie-tooth disease (CMT)
Intravital imaging
Motor neuron
Neuromuscular junction (NMJ)
Neurotrophic factors
Neurotrophins
Peripheral neuropathy
Trk receptors
YARS1
AbbreviationsAAV
adeno-associated virus
AChR
acetylcholine receptor
ANOVA
analysis of variance
ARS
aminoacyl-tRNA synthetase
BDNF
brain-derived neurotrophic factor
ChAT
choline acetyltransferase
CMT
Charcot-Marie-Tooth Disease
DIC
dynein intermediate chain
DI-CMTC
dominant intermediate CMT type C
DRG
dorsal root ganglion/ganglia
FDB
flexor digitorum brevis
GlyRS
glycyl-tRNA synthetase
HCT
atoxic binding fragment of the tetanus neurotoxin
HDAC6
histone deacetylase 6
ISR
integrated stress response
NCV
nerve conduction velocity
NMJ
neuromuscular junction
NT-3/4/5
neurotrophin-3/4/5
scAAV
self-complementary AAV
Trk
tropomyosin receptor kinase
TyrRS
tyrosyl-tRNA synthetase
Data availability
The data that support the findings of this study are available from the corresponding author, [JNS], upon reasonable request.
© 2024 The Authors. Published by Elsevier Inc.
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