Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73:17–48.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209–49.
Chen P, Liu Y, Wen Y, Zhou C. Non-small cell lung cancer in China. Cancer Commun. 2022;42:937–70.
Grunnet M, Sorensen JB. Carcinoembryonic antigen (CEA) as tumor marker in lung cancer. Lung Cancer. 2012;76:138–43.
Article CAS PubMed Google Scholar
Molina R, Auge JM, Bosch X, Escudero JM, Vinolas N, Marrades R, et al. Usefulness of serum tumor markers, including progastrin-releasing peptide, in patients with lung cancer: correlation with histology. Tumour Biol. 2009;30:121–9.
Article CAS PubMed Google Scholar
National-Comprehensive-Cancer-Network (NCCN). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Non-Small Cell Lung Cancer. (Version 2.2023). Fort Washington, PA: National Comprehensive Cancer Network (2023).
Postmus PE, Kerr KM, Oudkerk M, Senan S, Waller DA, Vansteenkiste J, et al. Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2017;28:iv1–iv21.
Article CAS PubMed Google Scholar
Jiao Z, Cao S, Li J, Hu N, Gong Y, Wang L, et al. Clinical Associations of Preoperative and Postoperative Serum CEA and Lung Cancer Outcome. Front Mol Biosci. 2021;8:686313.
Article PubMed PubMed Central Google Scholar
Wang CY, Huang MS, Huang MH, Lee HC, Hsu HS. Persistently high serum carcinoembryonic antigen levels after surgery indicate poor prognosis in patients with stage I non-small-cell lung cancer. J Surg Res. 2010;163:e45–e50.
Tomita M, Ayabe T, Chosa E, Nakamura K. Postoperative Serum CEA level is a more significant prognostic factor than post/preoperative serum CEA ratio in non-small cell cancer patients. Asian Pac J Cancer Prev. 2015;16:7809–12.
Kozu Y, Maniwa T, Takahashi S, Isaka M, Ohde Y, Nakajima T. Prognostic significance of postoperative serum carcinoembryonic antigen levels in patients with completely resected pathological-stage I non-small cell lung cancer. J Cardiothorac Surg. 2013;8:106.
Article PubMed PubMed Central Google Scholar
Nasralla A, Lee J, Dang J, Turner S. Elevated preoperative CEA is associated with subclinical nodal involvement and worse survival in stage I non-small cell lung cancer: a systematic review and meta-analysis. J Cardiothorac Surg. 2020;15:318.
Article PubMed PubMed Central Google Scholar
Wang XB, Li J, Han Y. Prognostic significance of preoperative serum carcinoembryonic antigen in non-small cell lung cancer: a meta-analysis. Tumour Biol. 2014;35:10105–10.
Article CAS PubMed Google Scholar
Li C, Zhang D, Pang X, Pu H, Lei M, Fan B, et al. Trajectories of perioperative serum tumor markers and colorectal cancer outcomes: a retrospective, multicenter longitudinal cohort study. EBioMedicine. 2021;74:103706.
Article CAS PubMed PubMed Central Google Scholar
Ozeki N, Fukui T, Taniguchi T, Usami N, Kawaguchi K, Ito S, et al. Significance of the serum carcinoembryonic antigen level during the follow-up of patients with completely resected non-small-cell lung cancer. Eur J Cardiothorac Surg. 2014;45:687–92.
Liu L, Gao S, He J, Hu J, Ge D, Li H, et al. Chinese thoracic surgery experts consensus on postoperative follow-up plans for non-small cell lung cancer patients. Chin J Clin Thorac Cardiovasc Surg. 2021;28:4–10. (in Chinese with English abstract)
Proust-Lima C, Philipps V, Liquet B. Estimation of extended mixed models using latent classes and latent processes: the R package lcmm. J Stat Softw. 2017;78:1–56.
Cook NR, Rosner BA, Chen W, Srinivasan SR, Berenson GS. Using the area under the curve to reduce measurement error in predicting young adult blood pressure from childhood measures. Stat Med. 2004;23:3421–35.
Pages F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, et al. International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study. Lancet. 2018;391:2128–39.
Harrell F E. rms: Regression Modeling Strategies. R package version 6.5-0. https://CRAN.R-project.org/package=rms (2023).
Wang P, Shen W, Boye ME. Joint modeling of longitudinal outcomes and survival using latent growth modeling approach in a mesothelioma trial. Health Serv Outcomes Res Methodol. 2012;12:182–99.
Article CAS PubMed PubMed Central Google Scholar
Sawabata N, Maeda H, Yokota S, Takeda S, Koma M, Tokunaga T, et al. Postoperative serum carcinoembryonic antigen levels in patients with pathologic stage IA nonsmall cell lung carcinoma: subnormal levels as an indicator of favorable prognosis. Cancer. 2004;101:803–9.
Article CAS PubMed Google Scholar
Tomita M, Matsuzaki Y, Shimizu T, Hara M, Ayabe T, Onitsuka T. Prognostic determinants for lung cancer patients with preoperative high serum carcinoembryonic antigen levels. Thorac Cardiovasc Surg. 2005;53:300–4.
Article CAS PubMed Google Scholar
Okada M, Nishio W, Sakamoto T, Uchino K, Yuki T, Nakagawa A, et al. Prognostic significance of perioperative serum carcinoembryonic antigen in non-small cell lung cancer: analysis of 1,000 consecutive resections for clinical stage I disease. Ann Thorac Surg. 2004;78:216–21.
Li Z, Li C, Pu H, Pang X, Wang Y, Zhang D, et al. Trajectories of perioperative serum carcinoembryonic antigen and colorectal cancer outcome: A retrospective, multicenter longitudinal cohort study. Clin Transl Med. 2021;11:e293.
Article CAS PubMed PubMed Central Google Scholar
Chen H, Jiang Y, Jia K, Zhang K, Matsuura N, Jeong JY, et al. Prognostic significance of postoperative longitudinal change of serum carcinoembryonic antigen level in patients with stage I lung adenocarcinoma completely resected by single-port video-assisted thoracic surgery: a retrospective study. Transl Lung Cancer Res. 2021;10:3983–94.
Article CAS PubMed PubMed Central Google Scholar
Thompson JA, Grunert F, Zimmermann W. Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal. 1991;5:344–66.
Article CAS PubMed Google Scholar
Blumenthal RD, Hansen HJ, Goldenberg DM. Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Cancer Res. 2005;65:8809–17.
Article CAS PubMed Google Scholar
Arrieta O, Saavedra-Perez D, Kuri R, Aviles-Salas A, Martinez L, Mendoza-Posada D, et al. Brain metastasis development and poor survival associated with carcinoembryonic antigen (CEA) level in advanced non-small cell lung cancer: a prospective analysis. BMC Cancer. 2009;9:119.
Article PubMed PubMed Central Google Scholar
Ferreira IG, Carrascal M, Mineiro AG, Bugalho A, Borralho P, Silva Z, et al. Carcinoembryonic antigen is a sialyl Lewis x/a carrier and an E‑selectin ligand in non‑small cell lung cancer. Int J Oncol. 2019;55:1033–48.
CAS PubMed PubMed Central Google Scholar
Ohwada A, Takahashi H, Nagaoka I, Iwabuchi K, Mikami O, Kira S. Effect of cigarette smoke on the mRNA and protein expression of carcinoembryonic antigen (CEA), a possible chemoattractant for neutrophils in human bronchioloalveolar tissues. Thorax. 1995;50:651–7.
Article CAS PubMed PubMed Central Google Scholar
Hao C, Zhang G, Zhang L. Serum CEA levels in 49 different types of cancer and noncancer diseases. Prog Mol Biol Transl Sci. 2019;162:213–27.
留言 (0)