Jaeschke H. Acetaminophen: dose-dependent drug hepatotoxicity and acute liver failure in patients. Dig Dis. 2015;33:464–71.

Article  PubMed  Google Scholar 

McGill MR, Hinson JA. The development and hepatotoxicity of acetaminophen: reviewing over a century of progress. Drug Metab Rev. 2020;52:472–500.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ortland I, Mirjalili M, Kullak-Ublick GA, Peymani P. Drug-induced liver injury in Switzerland: an analysis of drug-related hepatic disorders in the WHO pharmacovigilance database VigiBase from 2010 to 2020. Swiss Med Wkly. 2021;151:w20503.

Article  PubMed  Google Scholar 

Santos G, Figueira ERR, D’Albuquerque LAC, Lisboa PB, de Almeida MD, Filgueira NA, et al. Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil. Ann Hepatol. 2021;23:100310.

Article  PubMed  Google Scholar 

Darr U, Sussman NL. Drug-induced liver injury in the setting of analgesic use. Clin Liver Dis. 2020;24:121–9.

Article  PubMed  Google Scholar 

Chayanupatkul M, Schiano TD. Acute liver failure secondary to drug-induced liver injury. Clin Liver Dis. 2020;24:75–87.

Article  PubMed  Google Scholar 

Liu J, Jiang M, Jin Q, Wu YL, Cui ZY, Cui BW, et al. Modulation of HMGB1 release in APAP-induced liver injury: a possible strategy of Chikusetsusaponin V targeting NETs formation. Front Pharmacol. 2021;12:723881.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marques PE, Oliveira AG, Pereira RV, David BA, Gomides LF, Saraiva AM, et al. Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice. Hepatology. 2015;61:348–60.

Article  CAS  PubMed  Google Scholar 

Papackova Z, Heczkova M, Dankova H, Sticova E, Lodererova A, Bartonova L, et al. Silymarin prevents acetaminophen-induced hepatotoxicity in mice. PLoS One. 2018;13:e0191353.

Article  PubMed  PubMed Central  Google Scholar 

Chen L, Dong J, Liao S, Wang S, Wu Z, Zuo M, et al. Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury. Hepatology. 2022;76:1389–408.

Article  CAS  PubMed  Google Scholar 

Ghanem CI, Perez MJ, Manautou JE, Mottino AD. Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. Pharmacol Res. 2016;109:119–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He Y, Feng D, Li M, Gao Y, Ramirez T, Cao H, et al. Hepatic mitochondrial DNA/Toll-like receptor 9/MicroRNA-223 forms a negative feedback loop to limit neutrophil overactivation and acetaminophen hepatotoxicity in mice. Hepatology. 2017;66:220–34.

Article  CAS  PubMed  Google Scholar 

Zhao J, Kim JW, Zhou Z, Qi J, Tian W, Lim CW, et al. Macrophage-Inducible C-type lectin signaling exacerbates acetaminophen-induced liver injury by promoting Kupffer cell activation in mice. Mol Pharmacol. 2021;99:92–103.

Article  CAS  PubMed  Google Scholar 

Liu ZX, Govindarajan S, Kaplowitz N. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology. 2004;127:1760–74.

Article  CAS  PubMed  Google Scholar 

Guo H, Chen S, Xie M, Zhou C, Zheng M. The complex roles of neutrophils in APAP-induced liver injury. Cell Prolif. 2021;54:e13040.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldberger A, Hnilica LS, Casey SB, Briggs RC. Properties of a nuclear protein marker of human myeloid cell differentiation. J Biol Chem. 1986;261:4726–31.

Article  CAS  PubMed  Google Scholar 

Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532–5.

Article  CAS  PubMed  Google Scholar 

Huang H, Tohme S, Al-Khafaji AB, Tai S, Loughran P, Chen L, et al. Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury. Hepatology. 2015;62:600–14.

Article  CAS  PubMed  Google Scholar 

Zhao M, Wang Y, Li L, Liu S, Wang C, Yuan Y, et al. Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance. Theranostics. 2021;11:1845–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng F, Ma L, Li X, Wang Z, Gao R, Peng C, et al. Neutrophil extracellular traps induce glomerular endothelial cell dysfunction and pyroptosis in diabetic kidney disease. Diabetes. 2022;71:2739–50.

Article  CAS  PubMed  Google Scholar 

Zhang H, Liu J, Zhou Y, Qu M, Wang Y, Guo K, et al. Neutrophil extracellular traps mediate m6A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells. Int J Biol Sci. 2022;18:3337–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Xue W, Zhang W, Yuan Y, Zhu X, Wang Q, et al. Histone methyltransferase G9a protects against acute liver injury through GSTP1. Cell Death Differ. 2019;27:1243–58.

Article  PubMed  PubMed Central  Google Scholar 

Eaton JS, Lin ZP, Sartorelli AC, Bonawitz ND, Shadel GS. Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. J Clin Invest. 2007;117:2723–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malik AN, Shahni R, Rodriguez-de-Ledesma A, Laftah A, Cunningham P. Mitochondrial DNA as a non-invasive biomarker: Accurate quantification using real time quantitative PCR without co-amplification of pseudogenes and dilution bias. Biochem Biophys Res Commun. 2011;412:1–7.

Article  CAS  PubMed  Google Scholar 

Man SM, Karki R, Kanneganti TD. AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity. Eur J Immunol. 2016;46:269–80.

Article  CAS  PubMed  Google Scholar 

Zhao M, Zhou Y, Liu S, Li L, Chen Y, Cheng J, et al. Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury. Drug Deliv. 2018;25:546–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Y, Fan X, Jiao T, Li W, Chen P, Jiang Y, et al. SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation. Acta Pharm Sin B. 2021;11:89–99.

Article  CAS  PubMed  Google Scholar 

Block H, Rossaint J, Zarbock A. The fatal circle of NETs and NET-associated DAMPs contributing to organ dysfunction. Cells-Basel. 2022;11:1919.

Article  CAS  Google Scholar 

Lee S, Karki R, Wang Y, Nguyen LN, Kalathur RC, Kanneganti TD. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature. 2021;597:415–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Z, Wang M, Wang X, Bu Q, Wang Q, Su W, et al. XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury. Redox Biol. 2022;52:102305.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Niu B, Lei X, Xu Q, Ju Y, Xu D, Mao L, et al. Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury. Cell Biol Toxicol. 2022;38:505–30.

Article  CAS  PubMed  Google Scholar 

Ye H, Chen C, Wu H, Zheng K, Martin-Adrados B, Caparros E, et al. Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy. Cell Death Dis. 2022;13:143.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hussain S, Ashafaq M, Alshahrani S, Siddiqui R, Ahmed RA, Khuwaja G, et al. Cinnamon oil against acetaminophen-induced acute liver toxicity by attenuating inflammation, oxidative stress and apoptosis. Toxicol Rep. 2020;7:1296–304.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramachandran A, Jaeschke H. Acetaminophen hepatotoxicity: a mitochondrial perspective. Adv Pharmacol. 2019;85:195–219.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Zhang L, Shi Q, Yang B, He Q, Wang J, et al. Targeting innate immune responses to attenuate acetaminophen-induced hepatotoxicity. Biochem Pharmacol. 2022;202:115142.

Article  CAS  PubMed