Jakob J et al (2018) Regional chemotherapy by isolated limb perfusion prior to surgery compared with surgery and post-operative radiotherapy for primary, locally advanced extremity sarcoma: a comparison of matched cohorts. Clin Sarcoma Res 8:1–9
Sevilla-Ortega L et al (2021) Role of isolated limb perfusion in the era of targeted therapies and immunotherapy in melanoma. A systematic review of the literature. Cancers (Basel) 13:5485
Bhangu A, Broom L, Nepogodiev D, Gourevitch D, Desai A (2013) Outcomes of isolated limb perfusion in the treatment of extremity soft tissue sarcoma: A systematic review. Eur J Surg Oncol 39:311–319
Article CAS PubMed Google Scholar
Davies EJ, Reijers SJM, Van Akkooi ACJ, Van Houdt WJ, Hayes AJ (2022) Isolated limb perfusion for locally advanced melanoma in the immunotherapy era. Eur J Surg Oncol 48:1288–1292
Article CAS PubMed Google Scholar
Klopp CT, Alford TC, Bateman J, Berry GN, Winship T (1950) Fractionated intra-arterial cancer; chemotherapy with methyl bis amine hydrochloride; a preliminary report. Ann Surg 132:811–832
Article CAS PubMed PubMed Central Google Scholar
Creech O Jr, Ryan RF, Krementz ET (1959) Treatment of melanoma by isolation-perfusion technique. J Am Med Assoc 169:339–343
Cavaliere R et al (1967) Selective heat sensitivity of cancer cells. Biochem Clin Stud Cancer 20:1351–1381
Grünhagen DJ, de Wilt JHW, ten Hagen TLM, Eggermont AMM (2006) Technology Insight: utility of TNF-α-based isolated limb perfusion to avoid amputation of irresectable tumors of the extremities. Nat Clin Pract Oncol 3:94–103
Moreno-Ramirez D, Cruz-Merino L, Ferrandiz L, Villegas-Portero R, Nieto-Garcia A (2010) Isolated Limb Perfusion for Malignant Melanoma: Systematic Review on Effectiveness and Safety. Oncologist 15:416–427
Article PubMed PubMed Central Google Scholar
Vrouenraets BC, Nieweg OE, Kroon BBR (1996) Thirty-five years of isolated limb perfusion for melanoma: Indications and results. Br J Surg 83:1319–1328
Article CAS PubMed Google Scholar
Lienard D, Ewalenko P, Delmotte JJ, Renard N, Lejeune FJ (1992) High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. J Clin Oncol Off J Am Soc Clin Oncol 10:52–60
Lejeune FJ (2002) Clinical use of TNF revisited: improving penetration of anti-cancer agents by increasing vascular permeability. J Clin Invest 110:433–435
Article CAS PubMed PubMed Central Google Scholar
Van Der Veen AH et al (2000) TNF-α augments intratumoural concentrations of doxorubicin in TNF-α-based isolated limb perfusion in rat sarcoma models and enhances anti-tumour effects. Br J Cancer 82:973–980
Article PubMed PubMed Central Google Scholar
Eggermont AMM et al (1996) Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas: The cumulative multicenter European experience. Ann Surg 224:756–765
Article CAS PubMed PubMed Central Google Scholar
Bonvalot S et al (2009) Hyperthermic isolated limb perfusion in locally advanced soft tissue sarcoma and progressive desmoid-type fibromatosis with TNF 1 mg and melphalan (T1-M HILP) is safe and efficient. Ann Surg Oncol 16:3350–3357
Hayes AJ, Neuhaus SJ, Clark MA, Thomas JM (2007) Isolated limb perfusion with melphalan and tumor necrosis factor α for advanced melanoma and soft-tissue sarcoma. Ann Surg Oncol 14:230–238
Bonvalot S et al (2005) Limb salvage with isolated perfusion for soft tissue sarcoma: Could less TNF-α be better? Ann Oncol 16:1061–1068
Article CAS PubMed Google Scholar
Podleska LE et al (2014) Drug dosage in isolated limb perfusion: Evaluation of a limb volume model for extremity volume calculation. World J Surg Oncol 12:1–9
Deroose JP et al (2011) Long-term results of tumor necrosis factor α- and melphalan-based isolated limb perfusion in locally advanced extremity soft tissue sarcomas. J Clin Oncol 29:4036–4044
Article CAS PubMed Google Scholar
Van Ginkel RJ et al (2007) Isolated limb perfusion with tumor necrosis factor alpha and melphalan for locally advanced soft tissue sarcoma: Three time periods at risk for amputation. Ann Surg Oncol 14:1499–1506
Article PubMed PubMed Central Google Scholar
Erdmann F et al (2013) International trends in the incidence of malignant melanoma 1953–2008-are recent generations at higher or lower risk? Int J Cancer 132:385–400
Article CAS PubMed Google Scholar
Gershenwald JE, Scolyer RA (2018) Melanoma staging: American joint committee on cancer (AJCC) 8th edition and beyond. Ann Surg Oncol 25:2105–2110
Wolchok JD et al (2022) Long-term outcomes with nivolumab plus ipilimumab or nivolumab alone versus ipilimumab in patients with advanced melanoma. J Clin Oncol 40:127–137
Article CAS PubMed Google Scholar
Lebbé C et al (2019) Evaluation of two dosing regimens for nivolumab in combination with ipilimumab in patients with advanced melanoma: Results from the phase IIIb/IV CheckMate 511 trial. J Clin Oncol 37:867–875
Article PubMed PubMed Central Google Scholar
Ascierto PA et al (2013) Phase II trial (BREAK-2) of the BRAF inhibitor dabrafenib (GSK2118436) in patients with metastatic melanoma. J Clin Oncol 31:3205–3211
Article CAS PubMed Google Scholar
Pasquali S, Hadjinicolaou AV, Chiarion Sileni V, Rossi CR, Mocellin S (2018) Systemic treatments for metastatic cutaneous melanoma. Cochrane Database Syst Rev 2018
Hayes AJ, Clark MA, Harries M, Thomas JM (2004) Management of in-transit metastases from cutaneous malignant melanoma. Br J Surg 91:673–682
Article CAS PubMed Google Scholar
Read RL et al (2015) In-transit Melanoma Metastases: Incidence, Prognosis, and the Role of Lymphadenectomy. Ann Surg Oncol 22:475–481
Andtbacka RHI et al (2019) Final analyses of OPTiM: A randomized phase III trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor in unresectable stage III-IV melanoma. J Immunother Cancer 7:1–11
Nan Tie E, Henderson MA, Gyorki DE (2019) Management of in-transit melanoma metastases: a review. ANZ J Surg 89:647–652
Patel A, Carr MJ, Sun J, Zager JS (2022) In-transit metastatic cutaneous melanoma: current management and future directions. Clin Exp Metastasis 39:201–211
Eggermont AMM et al (2016) Prolonged Survival in Stage III Melanoma with Ipilimumab Adjuvant Therapy. N Engl J Med 375:1845–1855
Article CAS PubMed PubMed Central Google Scholar
Schachter J et al (2017) Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006). Lancet 390:1853–1862
Article CAS PubMed Google Scholar
Weber J et al (2017) Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma. N Engl J Med 377:1824–1835
Article CAS PubMed Google Scholar
Long GV et al (2017) Adjuvant Dabrafenib plus Trametinib in Stage III BRAF -Mutated Melanoma. N Engl J Med 377:1813–1823
Article CAS PubMed Google Scholar
Deroose JP et al (2012) 20 years experience of TNF-based isolated limb perfusion for in-transit melanoma metastases: TNF dose matters. Ann Surg Oncol 19:627–635
Koops HS et al (1998) Prophylactic isolated limb perfusion for localized, high-risk limb melanoma: results of a multicenter randomized phase III trial. European Organization for Research and Treatment of Cancer Malignant Melanoma Cooperative Group Protocol 18832, the World He. J Clin Oncol Off J Am Soc Clin Oncol 16:2906–2912
Cornett WR et al (2006) Randomized multicenter trial of hyperthermic isolated limb perfusion with melphalan alone compared with melphalan plus tumor necrosis factor: American College of Surgeons Oncology Group trial Z0020. J Clin Oncol 24:4196–4201
Article CAS PubMed Google Scholar
Lejeune FJ, Eggermont AMM (2007) Hyperthermic isolated limb perfusion with tumor necrosis factor is a useful therapy for advanced melanoma of the limbs [7]. J Clin Oncol 25:1449–1450
Thompson JF, Kam PC, Waugh RC, Harman CR (1998) Isolated limb infusion with cytotoxic agents: a simple alternative to isolated limb perfusion. Semin Surg Oncol 14:238–247
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