Retention rates and reasons for non-retention in exercise oncology trials in the post-treatment phase—a systematic review

Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, Zucker DS, Matthews CE, Ligibel JA, Gerber LH, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc. 2019;51(11):2375–90.

Article  PubMed  PubMed Central  Google Scholar 

Morris M, Crank H, Loosemore M, Stevinson C. Identification of research priorities in exercise oncology: a consensus study. J Cancer. 2020;11(9):2702–7.

Article  PubMed  PubMed Central  Google Scholar 

Courneya KS, Booth CM. Exercise as cancer treatment: a clinical oncology framework for exercise oncology research. Front Oncol. 2022;12:957135.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tudur Smith C, Hickey H, Clarke M, Blazeby J, Williamson P. The trials methodological research agenda: results from a priority setting exercise. Trials. 2014;15:32.

Article  PubMed  PubMed Central  Google Scholar 

Reynolds SA, O'Connor L, McGee A, Kilcoyne AQ, Connolly A, Mockler D, Guinan E, O'Neill L. Recruitment rates and strategies in exercise trials in cancer survivorship: a systematic review. J Cancer Surviv. 2023.

Gillies K, Kearney A, Keenan C, Treweek S, Hudson J, Brueton VC, Conway T, Hunter A, Murphy L, Carr PJ, et al. Strategies to improve retention in randomised trials. Cochrane Database Syst Rev. 2021;3(3):Mr000032.

PubMed  Google Scholar 

Parkinson B, Meacock R, Sutton M, Fichera E, Mills N, Shorter GW, Treweek S, Harman NL, Brown RCH, Gillies K, et al. Designing and using incentives to support recruitment and retention in clinical trials: a scoping review and a checklist for design. Trials. 2019;20(1):624.

Article  PubMed  PubMed Central  Google Scholar 

Sheill G, Guinan E, Brady L, Hevey D, Hussey J. Exercise interventions for patients with advanced cancer: a systematic review of recruitment, attrition, and exercise adherence rates. Palliat Support Care. 2019;17(6):686–96.

Article  CAS  PubMed  Google Scholar 

West MA, Loughney L, Lythgoe D, Barben CP, Sripadam R, Kemp GJ, Grocott MP, Jack S. Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: a blinded interventional pilot study. Br J Anaesth. 2015;114(2):244–51.

Article  CAS  PubMed  Google Scholar 

Brunsdon D, Biesty L, Brocklehurst P, Brueton V, Devane D, Elliott J, Galvin S, Gamble C, Gardner H, Healy P, et al. What are the most important unanswered research questions in trial retention? A James Lind Alliance Priority Setting Partnership: the PRioRiTy II (Prioritising Retention in Randomised Trials) study. Trials. 2019;20(1):593.

Article  PubMed  PubMed Central  Google Scholar 

Treweek S, Bevan S, Bower P, Campbell M, Christie J, Clarke M, Collett C, Cotton S, Devane D, El Feky A, et al. Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)? Trials. 2018;19(1):139.

Article  PubMed  PubMed Central  Google Scholar 

Casla S, López-Tarruella S, Jerez Y, Marquez-Rodas I, Galvão DA, Newton RU, Cubedo R, Calvo I, Sampedro J, Barakat R, Martín M. Supervised physical exercise improves VO2max, quality of life, and health in early stage breast cancer patients: a randomized controlled trial. Breast Cancer Res Treat. 2015;153(2):371–82. https://doi.org/10.1007/s10549-015-3541-x.

Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, Sami N, Lee K, Buchanan TA, Spicer DV, Tripathy D, Bernstein L, Mortimer JE. Effects of aerobic and resistance exercise on metabolic syndrome, sarcopenic obesity, and circulating biomarkers in overweight or obese survivors of breast cancer: a randomized controlled trial. J Clin Oncol. 2018;36(9):875–83. https://doi.org/10.1200/JCO.2017.75.7526. Erratum in: J Clin Oncol. 2020;38(12):1370. Erratum in: J Clin Oncol. 2020;38(18):2115.

Martin EA, Battaglini CL, Hands B, Naumann F. Higher-intensity exercise results in more sustainable improvements for vo2peak for breast and prostate cancer survivors. Oncol Nurs Forum. 2015;42(3):241–9. https://doi.org/10.1188/15.ONF.42-03AP.

Broderick JM, Guinan E, Kennedy MJ, Hollywood D, Courneya KS, Culos-Reed SN, Bennett K. DM OD, Hussey J: Feasibility and efficacy of a supervised exercise intervention in de-conditioned cancer survivors during the early survivorship phase: the PEACH trial. J Cancer Surviv. 2013;7(4):551–62.

Article  CAS  PubMed  Google Scholar 

Cantarero-Villanueva I, Fernández-Lao C, Díaz-Rodriguez L, Fernández-de-las-Peñas C, Del Moral-Avila R, Arroyo-Morales M. A multimodal exercise program and multimedia support reduce cancer-related fatigue in breast cancer survivors: a randomised controlled clinical trial. European J Integr Med. 2011;3(3):e189–200.

Article  Google Scholar 

Guinan E, Hussey J, Broderick JM, Lithander FE, O’Donnell D, Kennedy MJ, Connolly EM. The effect of aerobic exercise on metabolic and inflammatory markers in breast cancer survivors—a pilot study. Support Care Cancer. 2013;21(7):1983–92.

Article  CAS  PubMed  Google Scholar 

Sagen Å, Kåresen R, Risberg MA. Physical activity for the affected limb and arm lymphedema after breast cancer surgery. A prospective, randod controlled trial with two years follow-up. Acta Oncologica. 2009;48(8):1102–10.

Article  PubMed  Google Scholar 

Santa Mina D, Alibhai SMH, Matthew AG, Guglietti CL, Pirbaglou M, Trachtenberg J, Ritvo P. A randomized trial of aerobic versus resistance exercise in prostate cancer survivors. J Aging Phys Act. 2013;21(4):455–78.

Article  PubMed  Google Scholar 

Anderson RT, Kimmick GG, McCoy TP, Hopkins J, Levine E, Miller G, Ribisl P, Mihalko SL. A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial. J Cancer Surviv. 2012;6(2):172–81.

Article  PubMed  Google Scholar 

Greenlee HA, Crew KD, Mata JM, McKinley PS, Rundle AG, Zhang W, Liao Y, Tsai WY, Hershman DL. A pilot randomized controlled trial of a commercial diet and exercise weight loss program in minority breast cancer survivors. Obesity. 2013;21(1):65–76.

Article  CAS  PubMed  Google Scholar 

Pinto BM, Papandonatos GD, Goldstein MG, Marcus BH, Farrell N. Home-based physical activity intervention for colorectal cancer survivors. Psychooncology. 2013;22(1):54–64.

Article  PubMed  Google Scholar 

McNeely ML, Parliament MB, Seikaly H, Jha N, Magee DJ, Haykowsky MJ, Courneya KS. Sustainability of outcomes after a randomized crossover trial of resistance exercise for shoulder dysfunction in survivors of head and neck cancer. Physiother Can. 2015;67(1):85–93.

Article  PubMed  PubMed Central  Google Scholar 

Brocki BC, Andreasen J, Nielsen LR, Nekrasas V, Gorst-Rasmussen A, Westerdahl E. Short and long-term effects of supervised versus unsupervised exercise training on health-related quality of life and functional outcomes following lung cancer surgery—a randomized controlled trial. Lung Cancer. 2014;83(1):102–8.

Article  PubMed  Google Scholar 

Daley AJ, Crank H, Saxton JM, Mutrie N, Coleman R, Roalfe A. Randomized trial of exercise therapy in women treated for breast cancer. J Clin Oncol. 2007;25(13):1713–21.

Article  PubMed  Google Scholar 

Kampshoff CS, van Mechelen W, Schep G, Nijziel MR, Witlox L, Bosman L, Chinapaw MJ, Brug J, Buffart LM. Participation in and adherence to physical exercise after completion of primary cancer treatment. Int J Behav Nutr Phys Act. 2016;13(1):100.

Article  PubMed  PubMed Central  Google Scholar 

Kneis S, Wehrle A, Müller J, et al. It’s never too late-balance and endurance training improves functional performance, quality of life, and alleviates neuropathic symptoms in cancer survivors suffering from chemotherapy-induced peripheral neuropathy: results of a randomized controlled trial. BMC Cancer. 2019;19:414. https://doi.org/10.1186/s12885-019-5522-7.

Gothe NP, Erlenbach E. Feasibility of a yoga, aerobic and stretching-toning exercise program for adult cancer survivors: the STAYFit trial. J Cancer Surviv : Res Pract. 2022;16(5):1107–16.

Article  Google Scholar 

Papadopoulos E, Gillen J, Moore D, Au D, Kurgan N, Klentrou P, Finelli A, Alibhai SMH, Santa Mina D. High-intensity interval training or resistance training versus usual care in men with prostate cancer on active surveillance: a 3-arm feasibility randomized controlled trial. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2021;46(12):1535–44.

Article  CAS  PubMed  Google Scholar 

Harris LK, Skou ST, Juhl CB, Jäger M, Bricca A. Recruitment and retention rates in randomised controlled trials of exercise therapy in people with multimorbidity: a systematic review and meta-analysis. Trials. 2021;22(1):396.

Article  PubMed  PubMed Central  Google Scholar 

Kearney N, Connolly D, Begic S, Mockler D, Guinan E. Feasibility metrics of exercise interventions during chemotherapy: a systematic review. Crit Rev Oncol Hematol. 2024;195:104272. https://doi.org/10.1016/j.critrevonc.2024.104272.

Meneses-Echavez JF, Rodriguez-Prieto I, Elkins M, Martínez-Torres J, Nguyen L, Bidonde J. Analysis of reporting completeness in exercise cancer trials: a systematic review. BMC Med Res Methodol. 2019;19(1):220.

Article  PubMed  PubMed Central  Google Scholar 

Bland KA, Neil-Sztramko SE, Zadravec K, Medysky ME, Kong J, Winters-Stone KM, Campbell KL. Attention to principles of exercise training: an updated systematic review of randomized controlled trials in cancers other than breast and prostate. BMC Cancer. 2021;21(1):1179.

Article  PubMed  PubMed Central  Google Scholar 

Good clinical practice. Consolidated guideline. In: International conference on harmonisation of technical requirements for registration of pharaceuticals for human use. 1996.

https://www.hrb.ie/fileadmin/1._Non-plugin_related_files/RSF_files/Policies_and_principles/Grant_Policies/HRB_Policy_on_Clinical_Trials_and_Interventions_Governance.pdf.

Spence RR, Sandler CX, Jones TL, McDonald N, Dunn RM, Hayes SC. Practical suggestions for harms reporting in exercise oncology: the Exercise Harms Reporting Method (ExHaRM). BMJ Open. 2022;12(12):e067998.

Article  PubMed  PubMed Central  Google Scholar 

Nilsen TS, Scott JM, Michalski M, Capaci C, Thomas S, Herndon JE 2nd, Sasso J, Eves ND, Jones LW. Novel methods for reporting of exercise dose and adherence: an exploratory analysis. Med Sci Sports Exerc. 2018;50(6):1134–41.

Article  PubMed  PubMed Central  Google Scholar 

Fairman CM, Nilsen TS, Newton RU, Taaffe DR, Spry N, Joseph D, Chambers SK, Robinson ZP, Hart NH, Zourdos MC, et al. Reporting of resistance training dose, adherence, and tolerance in exercise oncology. Med Sci Sports Exerc. 2020;52(2):315–22.

Article  PubMed  Google Scholar 

O'Neill L, Murphy F, Reidy D, et al. Development and initial implementation of a clinical monitoring strategy in a non-regulated trial: a research note from the ReStOre II trial [version 2; peer review: 2 approved with reservations]. HRB Open Res. 2023;6:46. https://doi.org/10.12688/hrbopenres.13763.2.

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