Hill JO, Peters JC. Environmental contributions to the obesity epidemic. Science. 1998;280:1371–4.

Article  CAS  PubMed  Google Scholar 

Demeke S, Rohde K, Chollet-Hinton L, Sutton C, Kong KL, Fazzino TL. Change in hyper-palatable food availability in the US food system over 30 years: 1988-2018. Public Health Nutr. 2023;26:182–9.

Article  PubMed  Google Scholar 

Kenny PJ. Reward mechanisms in obesity: new insights and future directions. Neuron. 2011;69:664–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahn BH, Kim M, Kim SY. Brain circuits for promoting homeostatic and non-homeostatic appetites. Exp Mol Med. 2022;54:349–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berridge KC, Ho CY, Richard JM, Difeliceantonio AG. The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. Brain Res. 2010;1350:43–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferrario CR, Labouebe G, Liu S, Nieh EH, Routh VH, Xu S, et al. Homeostasis meets motivation in the battle to control food intake. J Neurosci. 2016;36:11469–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bijoch Ł, Klos J, Pawłowska M, Wiśniewska J, Legutko D, Szachowicz U, et al. Whole-brain tracking of cocaine and sugar rewards processing. Transl Psychiatry. 2023;13:20.

Article  PubMed  PubMed Central  Google Scholar 

Bijoch Ł, Klos J, Pękała M, Fiołna K, Kaczmarek L, Beroun A. Diverse processing of pharmacological and natural rewards by the central amygdala. Cell Rep. 2023;42:113036.

Article  CAS  PubMed  Google Scholar 

Nieh EH, Matthews GA, Allsop SA, Presbrey KN, Leppla CA, Wichmann R, et al. Decoding neural circuits that control compulsive sucrose seeking. Cell. 2015;160:528–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jennings JH, Rizzi G, Stamatakis AM, Ung RL, Stuber GD. The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding. Science. 2013;341:1517–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rossi MA, Basiri ML, McHenry JA, Kosyk O, Otis JM, Van Den Munkhof HE, et al. Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding. Science. 2019;364:1271–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bourdy R, Barrot M. A new control center for dopaminergic systems: pulling the VTA by the tail. Trends Neurosci. 2012;35:681–90.

Article  CAS  PubMed  Google Scholar 

Jhou TC, Geisler S, Marinelli M, Degarmo BA, Zahm DS. The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta. J Comp Neurol. 2009;513:566–96.

Article  PubMed  PubMed Central  Google Scholar 

Kaufling J, Veinante P, Pawlowski SA, Freund-Mercier M-J, Barrot M. gamma-Aminobutyric acid cells with cocaine-induced DeltaFosB in the ventral tegmental area innervate mesolimbic neurons. Biol Psychiatry. 2010;67:88–92.

Article  CAS  PubMed  Google Scholar 

Taylor NE, Long H, Pei JZ, Kukutla P, Phero A, Hadaegh F, et al. The rostromedial tegmental nucleus: A key modulator of pain and opioid analgesia. Pain. 2019;160:2524–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong S, Jhou TC, Smith M, Saleem KS, Hikosaka O. Negative reward signals from the lateral Habenula to Dopamine neurons are mediated by rostromedial tegmental nucleus in primates. J Neurosci. 2011;31:11457–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jhou TC, Fields HL, Baxter MG, Saper CB, Holland PC. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron. 2009;61:786–800.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sánchez-Catalán M-J, Barrot M. Fos response of the tail of the ventral tegmental area to food restriction entails a prediction error processing. Behav Brain Res. 2022;425:113826.

Article  PubMed  Google Scholar 

Godfrey N, Qiao M, Borgland SL. Activation of LH GABAergic inputs counteracts fasting-induced changes in tVTA/RMTG neurons. J Physiol. 2022;600:2203–24.

Article  CAS  PubMed  Google Scholar 

Bourdy R, Hertz A, Filliol D, Andry V, Goumon Y, Mendoza J, et al. The endocannabinoid system is modulated in reward and homeostatic brain regions following diet-induced obesity in rats: a cluster analysis approach. Eur J Nutr. 2021;60:4621–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bankhead P, Loughrey MB, Fernández JA, Dombrowski Y, McArt DG, Dunne PD, et al. QuPath: Open source software for digital pathology image analysis. Sci Rep. 2017;7:16878.

Article  PubMed  PubMed Central  Google Scholar 

Ferreira JGP, Del-Fava F, Hasue RH, Shammah-Lagnado SJ. Organization of ventral tegmental area projections to the ventral tegmental area-nigral complex in the rat. Neuroscience. 2008;153:196–213.

Article  CAS  PubMed  Google Scholar 

Balcita-Pedicino JJ, Omelchenko N, Bell R, Sesack SR. The inhibitory influence of the lateral habenula on midbrain dopamine cells: ultrastructural evidence for indirect mediation via the rostromedial mesopontine tegmental nucleus. J Comp Neurol. 2011;519:1143–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu R, Chen X, Zuo W, Li J, Kang S, Zhou L-H, et al. Ablation of μ opioid receptor-expressing GABA neurons in rostromedial tegmental nucleus increases ethanol consumption and regulates ethanol-related behaviors. Neuropharmacology. 2016;107:58–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown PL, Palacorolla H, Brady D, Riegger K, Elmer GI, Shepard PD. Habenula-induced inhibition of midbrain Dopamine neurons is diminished by lesions of the Rostromedial Tegmental nucleus. J Neurosci. 2017;37:217–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smith RJ, Vento PJ, Chao YS, Good CH, Jhou TC. Gene expression and neurochemical characterization of the rostromedial tegmental nucleus (RMTg) in rats and mice. Brain Struct Funct. 2019;224:219–38.

Article  CAS  PubMed  Google Scholar 

Dela Cruz JAD, Coke T, Karagiorgis T, Sampson C, Icaza-Cukali D, Kest K, et al. c-Fos induction in mesotelencephalic dopamine pathway projection targets and dorsal striatum following oral intake of sugars and fats in rats. Brain Res Bull. 2015;111:9–19.

Article  Google Scholar 

Chang G-Q, Karatayev O, Lukatskaya O, Leibowitz SF. Prenatal fat exposure and hypothalamic PPAR β/δ: Possible relationship to increased neurogenesis of orexigenic peptide neurons. Peptides. 2016;79:16–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

True C, Arik A, Lindsley S, Kirigiti M, Sullivan E, Kievit P. Early high-fat diet exposure causes dysregulation of the Orexin and Dopamine neuronal populations in nonhuman primates. Front Endocrinol. 2018;9:508.

Article  Google Scholar 

Wang S, Tan Y, Zhang JE, Luo M. Pharmacogenetic activation of midbrain dopaminergic neurons induces hyperactivity. Neurosci Bull. 2013;29:517–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boekhoudt L, Omrani A, Luijendijk MCM, Wolterink-Donselaar IG, Wijbrans EC, van der Plasse G, et al. Chemogenetic activation of dopamine neurons in the ventral tegmental area, but not substantia nigra, induces hyperactivity in rats. Eur Neuropsychopharmacol. 2016;26:1784–93.

Article  CAS  PubMed  Google Scholar 

Costall B, Domeney AM, Naylor RJ. Long-term consequences of antagonism by neuroleptics of behavioural events occurring during mesolimbic dopamine infusion. Neuropharmacology. 1984;23:287–94.

Article  CAS  PubMed  Google Scholar 

Bourdy R, Sánchez-Catalán MJ, Kaufling J, Balcita-Pedicino JJ, Freund-Mercier MJ, Veinante P, et al. Control of the nigrostriatal dopamine neuron activity and motor function by the tail of the ventral tegmental area. Neuropsychopharmacology. 2014;39:2788–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zweifel LS, Fadok JP, Argilli E, Garelick MG, Jones GL, Dickerson TMK, et al. Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety. Nat Neurosci. 2011;14:620–6.

Article  CAS  PubMed  PubMed Central