Scleral buckle infection is an unusual complication of retinal detachment surgery with an incidence ranging 0.5–5.6% in individuals, with Staphylococcus spp. being the most common pathogens [1]. It can endanger vision; therefore, prompt buckle removal is needed despite the risk of recurrent retinal detachment [1]. Acute retinal necrosis (ARN) is also a rare syndrome caused by the herpes virus family [2]. ARN is characterized by one or more foci of retinal necrosis in the periphery of the retina, which may spread rapidly without antiviral therapy. It can also involve occlusive vasculopathy and a prominent inflammatory reaction [2].

Herein, we report the clinical manifestations of a patient with concomitant methicillin-resistant S. aureus (MRSA) scleral buckle infection and ARN. We also propose the possible mechanisms underlying the coexistence of these two rare conditions.