Cumulative risk of revision after primary total hip arthroplasty in registries: Systematic review and meta-analysis of selected hip stems and cups

Abstract

Purpose The objective was to investigate the consistency in cumulative revision rates for a selection of total hip arthroplasty cups and stems across national/regional hip arthroplasty registries worldwide. Methods Ten cups and 10 stems from total hip systems were randomly selected. Two frequently used implants across registries were added, totalling 11 cups and 11 stems. Cumulative revision rates (CRR) and 95%CIs were extracted from the latest annual registry reports using these implants. CRRs were pooled for each cup or stem, and differences between cup-stem combinations and between registries were investigated. Results CRRs were available for 10 cups and 8 stems from 8 registries, totalling 552,148 cups and 727,447 stems. Follow-up was 1-20 years. Five-year CRRs pooled on all cups was 2.9% (95%CI 2.3 to 3.6) and on all stems 3.0% (95%CI 2.4 to 3.8). Homogenous (consistent) CRRs with respect to both, associated implant and country, were observed for 2 cups and 3 stems. Significant differences in CRR were identified in 1 cup by associated implant only, in 1 cup by registry only, and in 2 cups and 4 stems for both. Sparse data prevented evaluation of 4 cups and 1 stem. Conclusion Registries annual reports provide a large amount of publicly available information on CRRs of specific implants. These CRRs can be synthesized to improve the assessment of implant performance over time. Our CRR analysis represents a promising approach to detect implants with a consistent low- or high-risk pattern across registries.

Competing Interest Statement

CC declares no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. JAS declares no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. CB declares no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. LAH declares no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. RN is currently secretary general of European Federation National Associations Orthopaedics and Traumatology (EFORT), and member of the chair registration board of Dutch Arthroplasty Register (LROI). PJM declares no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. AL declares no conflicts of interest. AL is the current president elect of the International Society of Arthroplasty Registries (ISAR). BB declares no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. CB declares no Competing Financial Interests and declares the following Non-Financial Interest: he is currently member of SIRIS hip & knee Scientific Advisory Board (Swiss Joint Registry) ML declares no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. KM declares no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. OM declares no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. RH declares no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. AS is contract holder for the analysis of the National Joint Registry of England, Wales and Northern Ireland. AS is unpaid co-chair of the ISAR Benchmarking working group. LNS declares no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Clinical Protocols

https://osf.io/6gmyx

Funding Statement

This study was supported by a Horizon 2020 grant from the European Union (project number 965246).

Author Declarations

I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

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I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).

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I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.

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Data Availability

All data analyzed in this studies are publicly available in the annual reports of arthroplasty registries.

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