Unexpected positive culture (UPC) in adults revision spine surgery: a systematic review and meta-analysis of incidence, risk factors, and management

Mok JM, Cloyd JM, Bradford DS, Hu SS, Deviren V, Smith JA et al (2009) Reoperation after primary fusion for adult spinal deformity: rate, reason, and timing. Spine 34(8):832–839

Article  PubMed  Google Scholar 

Pichelmann MA, Lenke LG, Bridwell KH, Good CR, O’Leary PT, Sides BA (2010) Revision rates following primary adult spinal deformity surgery: six hundred forty-three consecutive patients followed-up to twenty-two years postoperative. Spine 35(2):219–226

Article  PubMed  Google Scholar 

Zhu F, Bao H, Liu Z, Bentley M, Zhu Z, Ding Y et al (2014) Unanticipated revision surgery in adult spinal deformity: an experience with 815 cases at one institution. Spine 39(26B):B36–B44

Article  PubMed  Google Scholar 

Dapunt U, Bürkle C, Günther F, Pepke W, Hemmer S, Akbar M (2017) Surgical site infections following instrumented stabilization of the spine. Ther Clin Risk Manag 13:1239

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lewkonia P, DiPaola C, Street J (2016) Incidence and risk of delayed surgical site infection following instrumented lumbar spine fusion. J Clin Neurosci 23:76–80

Article  PubMed  Google Scholar 

Kelly MP, Lenke LG, Bridwell KH, Agarwal R, Godzik J, Koester L (2013) The fate of the adult revision spinal deformity patient: a single institution experience. Spine 38(19):E1196

Article  PubMed  PubMed Central  Google Scholar 

Yilgor C, Sogunmez N, Yavuz Y, Boissiere L, Obeid I, Acaroglu E et al (2017) Global alignment and proportion (GAP) score: development and validation of a new method of analyzing spinopelvic alignment to predict mechanical complications after adult spinal deformity surgery. Spine J 17(10):S155–S156

Article  Google Scholar 

Trampuz A, Piper KE, Jacobson MJ, Hanssen AD, Unni KK, Osmon DR et al (2007) Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med 357(7):654–663

Article  CAS  PubMed  Google Scholar 

Pumberger M, Bürger J, Strube P, Akgün D, Putzier M (2019) Unexpected positive cultures in presumed aseptic revision spine surgery using sonication. Bone Joint J. 101-b(5):621–624

Article  CAS  PubMed  Google Scholar 

Saleh A, Guirguis A, Klika AK, Johnson L, Higuera CA, Barsoum WK (2014) Unexpected positive intraoperative cultures in aseptic revision arthroplasty. J Arthroplasty 29(11):2181–2186

Article  PubMed  Google Scholar 

Bongers J, Jacobs AM, Smulders K, Goosen JH (2020) Reinfection and re-revision rates of 113 two-stage revisions in infected TKA. J Bone Joint Infect 5(3):137–144

Article  Google Scholar 

Di Benedetto P, Dalla Vecchia G, Dante F, Gisonni R, Cainero V, Causero A (2019) Leukocyte esterase strip test as a reliable intraoperative PJIs biomarker. Our experience. Acta Bio Medica Atenei Parmensis. 90(Suppl 12):43

PubMed  PubMed Central  Google Scholar 

Portillo ME, Salvadó M, Alier A, Sorli L, Martínez S, Horcajada JP et al (2013) Prosthesis failure within 2 years of implantation is highly predictive of infection. Clin Orthop Related Res. 471(11):3672–3678

Article  Google Scholar 

Rasouli MR, Harandi AA, Adeli B, Purtill JJ, Parvizi J (2012) Revision total knee arthroplasty: infection should be ruled out in all cases. J Arthroplasty 27(6):1239-1243.e2

Article  PubMed  Google Scholar 

Tubb CC, Polkowksi GG, Krause B (2020) Diagnosis and prevention of periprosthetic joint infections. JAAOS-J Am Acad Orthop Surg 28(8):e340–e348

Article  Google Scholar 

van den Kieboom J, Tirumala V, Box H, Oganesyan R, Klemt C, Kwon Y-M (2021) One-stage revision is as effective as two-stage revision for chronic culture-negative periprosthetic joint infection after total hip and knee arthroplasty: a retrospective cohort study. Bone Joint J 103(3):515–521

Article  PubMed  Google Scholar 

Del Pozo JL, Patel R (2009) Infection associated with prosthetic joints. N Engl J Med 361(8):787–794

Article  PubMed  PubMed Central  Google Scholar 

Marculescu C, Berbari E, Hanssen A, Steckelberg J, Osmon DR (2005) Prosthetic joint infection diagnosed postoperatively by intraoperative culture. Clin Orthop Related Res 439:38–42

Article  CAS  Google Scholar 

Moojen DJF, van Hellemondt G, Vogely HC, Burger BJ, Walenkamp GH, Tulp NJ et al (2010) Incidence of low-grade infection in aseptic loosening of total hip arthroplasty: a prospective multicenter study using extensive routine and broad-range 16S PCR with reverse line blot diagnostics. Acta Orthop 81(6):667–673

Article  PubMed  PubMed Central  Google Scholar 

Ribera A, Morata L, Moranas J, Agulló J, Martínez J, Lopez Y et al (2014) Clinical and microbiological findings in prosthetic joint replacement due to aseptic loosening. J Infect 69(3):235–243

Article  CAS  PubMed  Google Scholar 

Chaichana KL, Bydon M, Santiago-Dieppa DR, Hwang L, McLoughlin G, Sciubba DM et al (2014) Risk of infection following posterior instrumented lumbar fusion for degenerative spine disease in 817 consecutive cases. J Neurosurg Spine 20(1):45–52

Article  PubMed  Google Scholar 

Kasliwal MK, Tan LA, Traynelis VC (2013) Infection with spinal instrumentation: review of pathogenesis, diagnosis, prevention, and management. Surg Neurol Int 4(Suppl 5):S392

PubMed  PubMed Central  Google Scholar 

Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M et al (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 350:g7647

Article  PubMed  Google Scholar 

Howick J, Chalmers I, Glasziou P, Greenhalgh T, Heneghan C, Liberati A, Moschetti I, Phillips B, Thornton H (2011). The 2011 Oxford CEBM Levels of Evidence (Introductory Document). Oxford Centre for Evidence-Based Medicine. https://www.cebm.ox.ac.uk/resources/levels-of-evidence/ocebm-levels-of-evidence

Higgins JPT, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558

Article  PubMed  Google Scholar 

Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ et al (2019) Cochrane handbook for systematic reviews of interventions. Wiley, New York

Book  Google Scholar 

Hu X, Lieberman IH (2018) Revision spine surgery in patients without clinical signs of infection: how often are there occult infections in removed hardware? Eur Spine J 27(10):2491–2495

Article  PubMed  Google Scholar 

Shiban E, Joerger AK, Janssen I, Issa M, Lange N, Wagner A et al (2020) Low-grade infection and implant failure following spinal instrumentation: a prospective comparative study. Neurosurgery 87(5):964–970

Article  PubMed  Google Scholar 

Leitner L, Malaj I, Sadoghi P, Amerstorfer F, Glehr M, Vander K et al (2018) Pedicle screw loosening is correlated to chronic subclinical deep implant infection: a retrospective database analysis. Eur Spine J 27(10):2529–2535

Article  PubMed  Google Scholar 

Ohrt-Nissen S, Fritz B, Valentin L, Kragh KN, Manniche C, Dahl B et al (2019) Is pseudarthrosis after spinal instrumentation caused by a chronic infection? Eur Spine J 28(12):2996–3002

Article  PubMed  Google Scholar 

Prinz V, Bayerl S, Renz N, Trampuz A, Czabanka M, Woitzik J et al (2019) High frequency of low-virulent microorganisms detected by sonication of pedicle screws: a potential cause for implant failure. J Neurosurg Spine 31(3):424–429

Article  PubMed  Google Scholar 

Siller S, Skrap B, Grabein B, Trabold R, Zausinger S, Tonn JC (2022) Routine intraoperative microbiological smear testing in patients with reoperation after elective degenerative non-instrumented spine surgery-useful or negligible adjunct. Acta Neurochir (Wien) 164(3):891–901

Article  PubMed  Google Scholar 

Agarwal A, Mooney M, Agarwal AG, Jayaswal D, Saakyan G, Goel V et al (2020) High prevalence of biofilms on retrieved implants from aseptic pseudarthrosis cases. Spine Surg Relat Res 5(2):104–108

Article  PubMed  PubMed Central  Google Scholar 

Burkhard MD, Loretz R, Uçkay I, Bauer DE, Betz M, Farshad M (2021) Occult infection in pseudarthrosis revision after spinal fusion. Spine J 21(3):370–376

Article  PubMed  Google Scholar 

Dupré DA, Cheng B, Kreft R, Nistico L, Ehrlich GD, Averick S et al (2022) The presence of biofilms in instrumented spinal fusions. Genet Test Mol Biomarkers 26(7–8):375–381

Article  PubMed  Google Scholar 

Shifflett GD, Bjerke-Kroll BT, Nwachukwu BU, Kueper J, Burket J, Sama AA et al (2016) Microbiologic profile of infections in presumed aseptic revision spine surgery. Eur Spine J 25(12):3902–3907

Article  PubMed  Google Scholar 

Burkhard MD, Hassanzadeh A, Andronic O, Götschi T, Uçkay I, Farshad M (2022) Clinical relevance of occult infections in spinal pseudarthrosis revision. N Am Spine Soc J (NASSJ) 12:100172

Article  PubMed  Google Scholar 

García-Pérez D, Lagares A, Castaño-León AM, Panero I, Munarriz PM, Delgado-Fernández J et al (2021) Implant microbial colonization detected by sonication as a cause for spinal device failure: a prospective study. Spine 46(21):1485–1494

Article  PubMed  Google Scholar 

Steinhaus ME, Salzmann SN, Lovecchio F, Shifflett GD, Yang J, Kueper J et al (2019) Risk factors for positive cultures in presumed aseptic revision spine surgery. Spine 44(3):177–184

Article  PubMed  Google Scholar 

Burkhard MD, Hassanzadeh A, Andronic O, Götschi T, Uçkay I, Farshad M (2022) Clinical relevance of occult infections in spinal pseudarthrosis revision. N Am Spine Soc J (NASSJ). 12:100172

Article  PubMed  PubMed Central 

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