Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001;414(6859):105–11.

Article  CAS  PubMed  Google Scholar 

Trumpp A, Haas S. Cancer stem cells: The adventurous journey from hematopoietic to leukemic stem cells. Cell. 2022;185:1266–70.

Article  CAS  PubMed  Google Scholar 

Velten L, Story BA, Hernández-Malmierca P, Raffel S, Leonce DR, Milbank J, Paulsen M, Demir A, Szu-Tu C, Frömel R, Lutz C, Nowak D, Jann J-C, Pabst C, Boch T, Hofmann W-K, Müller-Tidow C, Trumpp A, Haas S, Steinmetz LM.'Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics'. Nat Commun. 2021;12:1366.

Yang L, Shi P, Zhao G, Xu J, Peng W, Zhang J, Zhang G, Wang X, Dong Z, Chen F, Cui H. Targeting cancer stem cell pathways for cancer therapy. Sig Transduct Target Ther. 2020;5:8.

Pajuelo-Lozano N, Alcala S, Sainz B Jr, Perona R, Sanchez-Perez I. Targeting MAD2 modulates stemness and tumorigenesis in human Gastric Cancer cell lines. Theranostics. 2020;10:9601–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei M, Nurjanah U, Li J, Luo X, Hosea R, Li Y, Zeng J, Duan W, Song G, Miyagishi M, Kasim V, Wu S. YY2-DRP1 Axis Regulates Mitochondrial Fission and Determines Cancer Stem Cell Asymmetric Division. Adv Sci (Weinh). 2023;10:e2207349.

Article  PubMed  Google Scholar 

Dongre A, Weinberg RA. New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol. 2019;20:69–84.

Article  CAS  PubMed  Google Scholar 

Verstappe J, Berx G. A role for partial epithelial-to-mesenchymal transition in enabling stemness in homeostasis and cancer. Semin Cancer Biol. 2023;90:15–28.

Article  CAS  PubMed  Google Scholar 

Huang Tianzhi, Song Xiao, Dandan Xu, Tiek Deanna, Goenka Anshika, Bingli Wu, Sastry Namratha, Bo Hu, Cheng Shi-Yuan. Stem cell programs in cancer initiation, progression, and therapy resistance. Theranostics. 2020;10:8721–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prager BC, Xie Q, Bao S, Rich JN. Cancer Stem Cells: The Architects of the Tumor Ecosystem. Cell Stem Cell. 2019;24:41–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie XP, Laks DR, Sun D, Ganbold M, Wang Z, Pedraza AM, Bale T, Tabar V, Brennan C, Zhou X, Parada LF. Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion and recurrence following chemotherapy. Developmental cell. 2022;57:32–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Steinbichler, Teresa Bernadette, Dragana Savic, József Dudás, Irma Kvitsaridze, Sergej Skvortsov, Herbert Riechelmann, and Ira-Ida Skvortsova. 'Cancer stem cells and their unique role in metastatic spread'. Seminars in cancer biology. 2020; 60: 148–56.

Abad E, Graifer D, Lyakhovich A. DNA damage response and resistance of cancer stem cells. Cancer Lett. 2020;474:106–17.

Article  CAS  PubMed  Google Scholar 

Zhang R, Tu J, Liu S. Novel molecular regulators of breast cancer stem cell plasticity and heterogeneity. Semin Cancer Biol. 2022;82:11–25.

Article  CAS  PubMed  Google Scholar 

Rodriguez J, Larson DR. Transcription in Living Cells: Molecular Mechanisms of Bursting. Annu Rev Biochem. 2020;89:189–212.

Article  CAS  PubMed  Google Scholar 

Pope SD, Medzhitov R. Emerging Principles of Gene Expression Programs and Their Regulation. Mol Cell. 2018;71:389–97.

Article  CAS  PubMed  Google Scholar 

Cramer P. Organization and regulation of gene transcription. Nature. 2019;573:45–54.

Article  CAS  PubMed  Google Scholar 

Oudelaar AM, Higgs DR. The relationship between genome structure and function. Nat Rev Genet. 2021;22:154–68.

Article  CAS  PubMed  Google Scholar 

Popp AP, Hettich J, Gebhardt JCM. Altering transcription factor binding reveals comprehensive transcriptional kinetics of a basic gene. Nucleic Acids Res. 2021;49:6249–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Quintero-Cadena P, Lenstra TL, Sternberg PW. RNA Pol II Length and Disorder Enable Cooperative Scaling of Transcriptional Bursting. Mol Cell. 2020;79:207–20 (e8).

Article  CAS  PubMed  Google Scholar 

Ravi VM, Will P, Kueckelhaus J, Sun N, Joseph K, Salie H, Vollmer L, Kuliesiute U, von Ehr J, Benotmane JK, Neidert N, Follo M, Scherer F, Goeldner JM, Behringer SP, Franco P, Khiat M, Zhang J, Hofmann UG, Fung C, Ricklefs FL, Lamszus K, Boerries M, Ku M, Beck J, Sankowski R, Schwabenland M, Prinz M, Schuller U, Killmer S, Bengsch B, Walch AK, Delev D, Schnell O, Heiland DH. Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma. Cancer Cell. 2022;40:639–55 (e13).

Article  CAS  PubMed  Google Scholar 

Lytle NK, Barber AG, Reya T. Stem cell fate in cancer growth, progression and therapy resistance. Nat Rev Cancer. 2018;18:669–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang DC, Wang X. Clinical significance of spatiotemporal transcriptional bursting and control. Clin Transl Med. 2021;11:e518.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaudhary A, Raza SS, Haque R. Transcriptional factors targeting in cancer stem cells for tumor modulation. Semin Cancer Biol. 2023;88:123–37.

Article  CAS  PubMed  Google Scholar 

Yan Q, Fang X, Li C, Lan P, Guan X. Oncofetal proteins and cancer stem cells. Essays Biochem. 2022;66:423–33.

Article  CAS  PubMed  Google Scholar 

Cui G, Xu Y, Cao S, Shi K. Inducing somatic cells into pluripotent stem cells is an important platform to study the mechanism of early embryonic development. Mol Reprod Dev. 2022;89:70–85.

Article  CAS  PubMed  Google Scholar 

Vishnubalaji R, Shaath H, Al-Alwan M, Abdelalim EM, Alajez NM. Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers. Semin Cancer Biol. 2022;87:1–16.

Article  CAS  PubMed  Google Scholar 

Fatma, H., and H. R. Siddique.'Cancer cell plasticity, stem cell factors, and therapy resistance: how are they linked?' . Cancer Metastasis Rev. 2023.

Mohiuddin IS, Wei SJ, Kang MH. Role of OCT4 in cancer stem-like cells and chemotherapy resistance. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165432.

Article  CAS  PubMed  Google Scholar 

Nathansen J, Lukiyanchuk V, Hein L, Stolte MI, Borgmann K, Lock S, Kurth I, Baumann M, Krause M, Linge A, Dubrovska A. Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L. Oncogene. 2021;40:4214–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Niu W, Fan X, Yang H, Zhao C, Fan J, Yao X, Fang Z. Oct4A palmitoylation modulates tumorigenicity and stemness in human glioblastoma cells. Neuro Oncol. 2023;25:82–96.

Article  PubMed  Google Scholar 

Liu HL, Tang HT, Yang HL, Deng TT, Xu YP, Xu SQ, Peng L, Wang Z, Fang Q, Kuang XY, Li QS. Oct4 Regulates the Transition of Cancer Stem-Like Cells to Tumor Endothelial-Like Cells in Human Liver Cancer. Front Cell Dev Biol. 2020;8:563316.

Novak D, Hüser L, Elton JJ, Umansky V, Altevogt P, Utikal J. SOX2 in development and cancer biology. Seminars in cancer biology. 2020;67:74–82.

Article  CAS  PubMed  Google Scholar 

Schaal CM, Bora-Singhal N, Kumar DM, Chellappan SP. Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer. Mol Cancer. 2018;17:149.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin Y, Xie CM, Li H, Tan M, Chen G, Schiff R, Xiong X, Sun Y. The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells. Proc Natl Acad Sci U S A. 2019;116:20528–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Najafzadeh, B., Z. Asadzadeh, R. Motafakker Azad, A. Mokhtarzadeh, A. Baghbanzadeh, H. Alemohammad, M. Abdoli Shadbad, P. Vasefifar, S. Najafi, and B. Baradaran.'The oncogenic potential of NANOG: An important cancer induction mediator'. J Cell Physiol. 2021; 236: 2443–58.

Yoon, C., J. Lu, B. C. Yi, K. K. Chang, M. C. Simon, S. Ryeom, and S. S. Yoon.'PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas'. Oncogenesis. 2021; 10: 12.

Chen J, Li H, Zhang B, Xiong Z, Jin Z, Chen J, Zheng Y, Zhu X, Zhang S. ABI2-mediated MEOX2/KLF4-NANOG axis promotes liver cancer stem cell and drives tumour recurrence. Liver Int. 2022;42:2562–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu Y, Huang S, Chen S, Chen J, Wang Z, Wang Y, Zheng H. SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial-mesenchymal transition by beta-catenin and Beclin1/autophagy signaling in colorectal cancer. Cell Death Dis. 2021;12:449.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin X, Zhang BH, Zheng SS, Gao DM, Qiu SJ, Wu WZ, Ren ZG. Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signaling. J Hematol Oncol. 2015;8:23.

Article  PubMed  PubMed Central