Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, Barnholtz-Sloan JS (2023) CBTRUS Statistical Report: primary brain and other Central Nervous System tumors diagnosed in the United States in 2016–2020. Neurooncology 25:iv1–iv99. https://doi.org/10.1093/neuonc/noad149

Article  Google Scholar 

Tan AC, Ashley DM, López GY, Malinzak M, Friedman HS, Khasraw M (2020) Management of glioblastoma: state of the art and future directions. Cancer J Clin 70:299–312. https://doi.org/10.3322/caac.21613

Article  Google Scholar 

Oronsky B, Reid TR, Oronsky A, Sandhu N, Knox SJ (2020) A review of newly diagnosed Glioblastoma. Front Oncol 10:574012. https://doi.org/10.3389/fonc.2020.574012

Article  PubMed  Google Scholar 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO (2005) Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma. N Engl J Med 352:987–996. https://doi.org/10.1056/NEJMoa043330

Article  CAS  PubMed  Google Scholar 

Fernandes C, Costa A, Osório L, Lago RC, Linhares P, Carvalho B, Caeiro C (2017) Current Standards of Care in Glioblastoma Therapy. In: De Vleeschouwer S (ed) Glioblastoma. Codon Publications Copyright: The Authors., Brisbane (AU)

Jordan JT, Gerstner ER, Batchelor TT, Cahill DP, Plotkin SR (2016) Glioblastoma care in the elderly. Cancer 122:189–197. https://doi.org/10.1002/cncr.29742

Article  PubMed  Google Scholar 

Young JS, Chmura SJ, Wainwright DA, Yamini B, Peters KB, Lukas RV (2017) Management of glioblastoma in elderly patients. J Neurol Sci 380:250–255. https://doi.org/10.1016/j.jns.2017.07.048

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Wasilewski A, Mohile NA (2020) Disparities in patient enrollment on glioblastoma clinical trials. CNS Oncol 9:Cns59. https://doi.org/10.2217/cns-2020-0008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murthy VH, Krumholz HM, Gross CP (2004) Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA 291:2720–2726. https://doi.org/10.1001/jama.291.22.2720

Article  CAS  PubMed  Google Scholar 

Pellerino A, Bruno F, Internò V, Rudà R, Soffietti R (2020) Current clinical management of elderly patients with glioma. Expert Rev Anticancer Ther 20:1037–1048. https://doi.org/10.1080/14737140.2020.1828867

Article  CAS  PubMed  Google Scholar 

Minniti G, Niyazi M, Alongi F, Navarria P, Belka C (2021) Current status and recent advances in reirradiation of glioblastoma. Radiat Oncol 16:36. https://doi.org/10.1186/s13014-021-01767-9

Article  PubMed  PubMed Central  Google Scholar 

Lipitz-Snyderman A, Pfister D, Classen D, Atoria CL, Killen A, Epstein AS, Anderson C, Fortier E, Weingart SN (2017) Preventable and mitigable adverse events in cancer care: measuring risk and harm across the continuum. Cancer 123:4728–4736. https://doi.org/10.1002/cncr.30916

Article  PubMed  Google Scholar 

Jairam V, Lee V, Park HS, Thomas CR Jr, Melnick ER, Gross CP, Presley CJ, Adelson KB, Yu JB (2019) Treatment-related complications of systemic therapy and Radiotherapy. JAMA Oncol 5:1028–1035. https://doi.org/10.1001/jamaoncol.2019.0086

Article  PubMed  PubMed Central  Google Scholar 

Yang M, Moon C (2013) Neurotoxicity of cancer chemotherapy. Neural Regen Res 8:1606–1614. https://doi.org/10.3969/j.issn.1673-5374.2013.17.009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong JM, Panchmatia JR, Ziewacz JE, Bader AM, Dunn IF, Laws ER, Gawande AA (2012) Patterns in neurosurgical adverse events: intracranial neoplasm surgery. Neurosurg Focus 33:E16. https://doi.org/10.3171/2012.7.Focus12183

Article  PubMed  Google Scholar 

Moloney EC, Brunner M, Alexander AJ, Clark J (2015) Quantifying fibrosis in head and neck cancer treatment: an overview. Head Neck 37:1225–1231. https://doi.org/10.1002/hed.23722

Article  PubMed  Google Scholar 

Morris ZS, Harari PM (2014) Interaction of radiation therapy with molecular targeted agents. J Clin Oncol 32:2886–2893. https://doi.org/10.1200/jco.2014.55.1366

Article  CAS  PubMed  PubMed Central  Google Scholar 

Unger JM, Vaidya R, Albain KS, LeBlanc M, Minasian LM, Gotay CC, Henry NL, Fisch MJ, Lee SM, Blanke CD Hershman DL Sex Differences in Risk of Severe Adverse Events in Patients Receiving Immunotherapy, Targeted Therapy, or Chemotherapy in Cancer Clinical Trials. Journal of Clinical Oncology 0: JCO.21.02377 https://doi.org/10.1200/jco.21.02377

Özdemir BC, Csajka C, Dotto GP, Wagner AD (2018) Sex differences in efficacy and toxicity of systemic treatments: an undervalued issue in the era of Precision Oncology. J Clin Oncol 36:2680–2683. https://doi.org/10.1200/jco.2018.78.3290

Article  CAS  PubMed  Google Scholar 

Chmielewski-Stivers N, Petit B, Ollivier J, Monceau V, Tsoutsou P, Quintela Pousa A, Lin X, Limoli C, Vozenin M-C (2021) Sex-specific differences in toxicity following systemic Paclitaxel treatment and localized Cardiac Radiotherapy. Cancers 13:3973

Article  CAS  PubMed  PubMed Central  Google Scholar 

Edward R, Berchick EH, Jessica C, Barnett (2018) Health Insurance Coverage in the United States: 2017. United States Census Bureau

Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, Barnholtz-Sloan Jill S (2022) CBTRUS Statistical Report: primary brain and other Central Nervous System tumors diagnosed in the United States in 2015–2019. Neurooncology 24:v1–v95. https://doi.org/10.1093/neuonc/noac202

Article  CAS  Google Scholar 

Cooper GS, Virnig B, Klabunde CN, Schussler N, Freeman J, Warren JL (2002) Use of SEER-Medicare data for measuring cancer surgery. Med Care 40:IV–43

Article  PubMed  Google Scholar 

Virnig BA, Warren JL, Cooper GS, Klabunde CN, Schussler N, Freeman J (2002) Studying radiation therapy using SEER-Medicare-linked data. Med Care 40:IV–49

Article  PubMed  Google Scholar 

Elixhauser A, Steiner C, Harris DR, Coffey RM (1998) Comorbidity measures for Use with Administrative Data. Med Care 36:8–27

Article  CAS  PubMed  Google Scholar 

Unger JM, Vaidya R, Albain KS, LeBlanc M, Minasian LM, Gotay CC, Henry NL, Fisch MJ, Lee SM, Blanke CD, Hershman DL (2022) Sex differences in risk of severe adverse events in patients receiving immunotherapy, targeted therapy, or Chemotherapy in Cancer clinical trials. J Clin Oncol 40:1474–1486. https://doi.org/10.1200/jco.21.02377

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wilcox NS, Rotz SJ, Mullen M, Song EJ, Ky Hamilton B, Moslehi J, Armenian SH, Wu JC, Rhee JW, Ky B (2022) Sex-Specific Cardiovascular risks of Cancer and its therapies. Circ Res 130:632–651. https://doi.org/10.1161/circresaha.121.319901

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hershman DL, McBride RB, Eisenberger A, Tsai WY, Grann VR, Jacobson JS (2008) Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-hodgkin’s lymphoma. J Clin Oncol 26:3159–3165. https://doi.org/10.1200/jco.2007.14.1242

Article  CAS  PubMed  Google Scholar 

Stabellini N, Krebs H, Patil N, Waite K, Barnholtz-Sloan JS (2021) Sex differences in Time to treat and outcomes for gliomas. Front Oncol 11:630597. https://doi.org/10.3389/fonc.2021.630597

Article  PubMed  PubMed Central  Google Scholar 

Ostrom QT, Krebs HL, Patil N, Cioffi G, Barnholtz-Sloan JS (2021) Racial/ethnic disparities in treatment pattern and time to treatment for adults with glioblastoma in the US. J Neurooncol 152:603–615. https://doi.org/10.1007/s11060-021-03736-4

Article  PubMed  Google Scholar 

Gállego Pérez-Larraya J, Delattre JY (2014) Management of elderly patients with gliomas. Oncologist 19:1258–1267. https://doi.org/10.1634/theoncologist.2014-0170

Article  PubMed  PubMed Central  Google Scholar 

Mason M, Laperriere N, Wick W, Reardon DA, Malmstrom A, Hovey E, Weller M, Perry JR (2016) Glioblastoma in the elderly: making sense of the evidence. Neurooncol Pract 3:77–86. https://doi.org/10.1093/nop/npv027

Article  PubMed  Google Scholar 

Braun K, Ahluwalia MS (2017) Treatment of Glioblastoma in older adults. Curr Oncol Rep 19:81. https://doi.org/10.1007/s11912-017-0644-z

Article  CAS  PubMed  Google Scholar 

Tavelin B, Malmström A (2022) Sex differences in glioblastoma-findings from the Swedish National Quality Registry for primary brain tumors between 1999–2018. J Clin Med 11. https://doi.org/10.3390/jcm11030486

Yang W, Warrington NM, Taylor SJ, Whitmire P, Carrasco E, Singleton KW, Wu N, Lathia JD, Berens ME, Kim AH, Barnholtz-Sloan JS, Swanson KR, Luo J, Rubin JB (2019) Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data. Sci Transl Med 11:eaao5253. https://doi.org/10.1126/scitranslmed.aao5253

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang C, Wang X, Hao S, Su Z, Zhang P, Li Y, Song G, Yu L, Wang J, Ji N, Xie J, Gao Z (2016) Analysis of treatment tolerance and Factors Associated with overall survival in Elderly patients with Glioblastoma. World Neurosurg 95:77–84. https://doi.org/10.1016/j.wneu.2016.07.079

Article  CAS  PubMed  Google Scholar 

Kushnir I, Tzuk-Shina T (2011) Efficacy of treatment for glioblastoma multiforme in elderly patients (65+): a retrospective analysis. Isr Med Assoc J 13:290–294