Effect of Single and Multiple Methotrexate Doses Treatment on Ovarian Reserve in Ectopic Pregnancy Women: A Prospective Cohort Study

Sahin C, Taylan E, Akdemir A, Ozgurel B, Taskıran D, Ergenoglu AM. The impact of salpingectomy and single-dose systemic methotrexate treatments on ovarian reserve in ectopic pregnancy. Eur J Obstetr Gynecol Reprod Biol. 2016;205:150–2.

Article  CAS  Google Scholar 

Van Den Eeden SK, Shan J, Bruce C, Glasser M. Ectopic pregnancy rate and treatment utilization in a large managed care organization. Obstet Gynecol. 2005;105:1052–7.

Article  PubMed  Google Scholar 

Oriol B, Barrio A, Pacheco A, Serna J, Zuzuarregui JL, Garcia-Velasco JA. Systemic methotrexate to treat ectopic pregnancy does not affect ovarian reserve. Fertil Steril. 2008;90:1579–82.

Article  CAS  PubMed  Google Scholar 

Mullany K, Minneci M, Monjazeb R. OCC. Overview of ectopic pregnancy diagnosis, management, and innovation. Womens Health (Lond). 2023;19:17455057231160348.

CAS  PubMed  PubMed Central  Google Scholar 

Taran F-A, Kagan K-O, Hübner M, Hoopmann M, Wallwiener D, Brucker S. The diagnosis and treatment of ectopic pregnancy. Dtsch Arztebl Int. 2015;112:693.

PubMed  PubMed Central  Google Scholar 

Hendriks E, Rosenberg R, Prine L. Ectopic pregnancy: diagnosis and management. Am Fam Physician. 2020;101:599–606.

PubMed  Google Scholar 

Al Naimi A, Moore P, Brüggmann D, Krysa L, Louwen F, Bahlmann F. Ectopic pregnancy: a single-center experience over ten years. Reprod Biol Endocrinol. 2021;19:1–6.

Article  Google Scholar 

Naveed AK, Anjum MU, Hassan A, Mahmood SN. Methotrexate versus expectant management in ectopic pregnancy: a meta-analysis. Arch Gynecol Obstetr. 2022;2022:1–7.

Google Scholar 

Zhang J, Zhang Y, Gan L, Liu X, Du S. Predictors and clinical features of methotrexate (MTX) therapy for ectopic pregnancy. BMC Pregnancy Childbirth. 2020;20:1–9.

Article  Google Scholar 

Cohen A, Bar-On S, Cohen Y, Sandel O, Fouks Y, Michaan N, et al. Ruptured ectopic pregnancies following methotrexate treatment: clinical course and predictors for improving patient counseling. Reprod Sci. 2022;29:1209–14.

Article  CAS  PubMed  Google Scholar 

Tas M, Oner G, Ulug P, Yavuz A, Ozcelik B. Evaluation of protective effects of GnRH agonist or antagonist on ovarian reserve with anti-Müllerian hormone and histological analysis in a rat model using cisplatin. Arch Med Sci. 2023;19:448.

Article  CAS  PubMed  Google Scholar 

Ahmed A, Khadija S, Irshad A. Causes of dysfunctional uterine bleeding in pre-menopausal, peri-menopausal and post-menopausal women: a systematic review of world literature between year 1992 to 2017: Causes of dysfunctional uterine bleeding. Pak BioMedical J. 2022:03-6.

Moolhuijsen LME, Visser JA. Anti-Müllerian hormone and ovarian reserve: Update on assessing ovarian function. J Clin Endocrinol Metab. 2020;105:3361–73.

Article  PubMed  PubMed Central  Google Scholar 

Almeida F, Costermans NGJ, Soede NM, Bunschoten A, Keijer J, Kemp B, et al. Presence of anti-Müllerian hormone (AMH) during follicular development in the porcine ovary. PLoS ONE. 2018;13: e0197894.

Article  PubMed  PubMed Central  Google Scholar 

Vrontikis A, Chang PL, Kovacs P, Lindheim SR. Antral follice counts (AFC) predict ovarian response and pregnancy outcomes in oocyte donation cycles. J Assist Reprod Genet. 2010;27:383–9.

Article  PubMed  PubMed Central  Google Scholar 

Sinha S, Sharan A, Sinha S. Anti-Mullerian hormone as a marker of ovarian reserve and function. Cureus. 2022;14: e29214.

PubMed  PubMed Central  Google Scholar 

Hill MJ, Cooper JC, Levy G, Alford C, Richter KS, DeCherney AH, et al. Ovarian reserve and subsequent assisted reproduction outcomes after methotrexate therapy for ectopic pregnancy or pregnancy of unknown location. Fertil Steril. 2014;101:413–9.

Article  CAS  PubMed  Google Scholar 

Benian A, Guralp O, Uzun DD, Okyar A, Sahmay S. The effect of repeated administration of methotrexate (MTX) on rat ovary: measurement of serum antimullerian hormone (AMH) levels. Gynecol Endocrinol. 2013;29:226–9.

Article  CAS  PubMed  Google Scholar 

Ulug P, Oner G. Evaluation of the effects of single or multiple dose methotrexate administration, salpingectomy on ovarian reserve of rat with the measurement of anti-Müllerian hormone (AMH) levels and histological analysis. Eur J Obstet Gynecol Reprod Biol. 2014;181:205–9.

Article  CAS  PubMed  Google Scholar 

Sharp SJ, Poulaliou M, Thompson SG, White IR, Wood AM. A review of published analyses of case-cohort studies and recommendations for future reporting. PLoS ONE. 2014;9: e101176.

Article  PubMed  PubMed Central  Google Scholar 

Shirazi M, Pooransari P, Hajiha N, Shaker Z, Ghazi M, Davari Tanha F, et al. Effect of single-dose methotrexate treatment on ovarian reserve in women with ectopic pregnancy undergoing infertility treatment: a single-center experience. Int J Fertil Steril. 2020;14:23–6.

CAS  PubMed  PubMed Central  Google Scholar 

Sahin C, Taylan E, Akdemir A, Ozgurel B, Taskıran D, Ergenoglu AM. The impact of salpingectomy and single-dose systemic methotrexate treatments on ovarian reserve in ectopic pregnancy. Eur J Obstet Gynecol Reprod Biol. 2016;205:150–2.

Article  CAS  PubMed  Google Scholar 

Boots CE, Gustofson RL, Feinberg EC. Does methotrexate administration for ectopic pregnancy after in vitro fertilization impact ovarian reserve or ovarian responsiveness? Fertil Steril. 2013;100:1590–3.

Article  CAS  PubMed  Google Scholar 

Uyar I, Yucel OU, Gezer C, Gulhan I, Karis B, Hanhan HM, et al. Effect of single-dose methotrexate on ovarian reserve in women with ectopic pregnancy. Fertil Steril. 2013;100:1310–3.

Article  CAS  PubMed  Google Scholar 

Mummert T, Gnugnoli DM. Ectopic Pregnancy. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2023, StatPearls Publishing LLC.; 2023.

ACOG Practice Bulletin No. 191: Tubal ectopic pregnancy. Obstet Gynecol. 2018;131:e65–77.

Article  Google Scholar 

Çetin F, Bayramoglu Tepe N, Kutlar AI. Evaluation of the effect of multi-dose methotrexate therapy on ovarian reserve in ectopic pregnancies: is polycystic ovarian morphology a protective condition for ovarian reserve? Ginekol Pol. 2023;94:407–14.

PubMed  Google Scholar 

Coelho Neto MA, Ludwin A, Borrell A, Benacerraf B, Dewailly D, da Silva CF, et al. Counting ovarian antral follicles by ultrasound: a practical guide. Ultrasound Obstet Gynecol. 2018;51:10–20.

Article  CAS  PubMed  Google Scholar 

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