Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57–70.

Article  CAS  PubMed  Google Scholar 

Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature. 1998;396(6712):643–9.

Article  CAS  PubMed  Google Scholar 

Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004;4(8):579–91.

Article  CAS  PubMed  Google Scholar 

Nikolaev YA, Cox CD, Ridone P, Rohde PR, Cordero-Morales JF, Vásquez V, et al. Mammalian TRP ion channels are insensitive to membrane stretch. J Cell Sci. 2019. https://doi.org/10.1242/jcs.238360.

Article  PubMed  PubMed Central  Google Scholar 

Voskarides K. The, “cancer-cold” hypothesis and possible extensions for the Nordic populations. Scandinavian J Public Health. 2019;47(5):477–81.

Article  Google Scholar 

Sharma A, Verma HK, Joshi S, Panwar MS, Mandal CC. A link between cold environment and cancer. Tumour Biol. 2015;36(8):5953–64.

Article  CAS  PubMed  Google Scholar 

Chatra K, Kuppili V, Edla DR, Verma AK. Cancer data classification using binary bat optimization and extreme learning machine with a novel fitness function. Med Biol Eng Comput. 2019;57(12):2673–82.

Article  PubMed  Google Scholar 

Wang Y, Guan J, Wang H, Wang Y, Leeper D, Iliakis G. Regulation of dna replication after heat shock by replication protein a-nucleolin interactions. J Biol Chem. 2001;276(23):20579–88.

Article  CAS  PubMed  Google Scholar 

Estrada LD, Ağaç D, Farrar JD. Sympathetic neural signaling via the β2-adrenergic receptor suppresses T-cell receptor-mediated human and mouse CD8(+) T-cell effector function. Eur J Immunol. 2016;46(8):1948–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bucsek MJ, Giridharan T, MacDonald CR, Hylander BL, Repasky EA. An overview of the role of sympathetic regulation of immune responses in infectious disease and autoimmunity. Int J Hypertherm. 2018;34(2):135–43.

Article  CAS  Google Scholar 

Robinson EL, Bagchi RA, Major JL, Bergman BC, Matsuda JL, McKinsey TA. HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance. J Clin Investig. 2023. https://doi.org/10.1172/JCI168192.

Article  PubMed  PubMed Central  Google Scholar 

Jin J, Miao C, Wang Z, Zhang W, Zhang X, Xie X, et al. Design and synthesis of aryloxypropanolamine as β(3)-adrenergic receptor antagonist in cancer and lipolysis. Eur J Med Chem. 2018;150:757–70.

Article  CAS  PubMed  Google Scholar 

Sereni F, Dal Monte M, Filippi L, Bagnoli P. Role of host β1- and β2-adrenergic receptors in a murine model of B16 melanoma: functional involvement of β3-adrenergic receptors. Naunyn Schmiedebergs Arch Pharmacol. 2015;388(12):1317–31.

Article  CAS  PubMed  Google Scholar 

Bellinger DL, Lorton D. Autonomic regulation of cellular immune function. Auton Neurosci. 2014;182:15–41.

Article  CAS  PubMed  Google Scholar 

Cohen S, Levi-Montalcini R, Hamburger V. A nerve growth-stimulating factor isolated from Sarcom as 37 and 180. Proc Natl Acad Sci USA. 1954;40(10):1014–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heitz F, Hengsbach A, Harter P, Traut A, Ataseven B, Schneider S, et al. Intake of selective beta blockers has no impact on survival in patients with epithelial ovarian cancer. Gynecol Oncol. 2017;144(1):181–6.

Article  CAS  PubMed  Google Scholar 

Barron TI, Connolly RM, Sharp L, Bennett K, Visvanathan K. Beta blockers and breast cancer mortality: a population- based study. J Clin Oncol. 2011;29(19):2635–44.

Article  CAS  PubMed  Google Scholar 

Melhem-Bertrandt A, Chavez-Macgregor M, Lei X, Brown EN, Lee RT, Meric-Bernstam F, et al. Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer. J Clin Oncol. 2011;29(19):2645–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang HM, Liao ZX, Komaki R, Welsh JW, O’Reilly MS, Chang JY, et al. Improved survival outcomes with the incidental use of beta-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy. Annal Oncol. 2013;24(5):1312–9.

Article  CAS  Google Scholar 

Lee KW, Tsai YS, Chiang FY, Huang JL, Ho KY, Yang YH, et al. Lower ataxia telangiectasia mutated (ATM) mRNA expression is correlated with poor outcome of laryngeal and pharyngeal cancer patients. Annal Oncol. 2011;22(5):1088–93.

Article  Google Scholar 

Ghanemi M, Pourshohod A, Ghaffari MA, Kheirollah A, Amin M, Zeinali M, et al. Specific Targeting of HER2-Positive Head and Neck Squamous Cell Carcinoma Line HN5 by Idarubicin-ZHER2 Affibody Conjugate. Curr Cancer Drug Targets. 2019;19(1):65–73.

Article  CAS  PubMed  Google Scholar 

Huang Z, Li G, Zhang Z, Gu R, Wang W, Lai X, et al. β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells. BMC Cancer. 2019;19(1):1142.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eng JW, Reed CB, Kokolus KM, Pitoniak R, Utley A, Bucsek MJ, et al. Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation. Nat Commun. 2015;6:6426.

Article  CAS  PubMed  Google Scholar 

Al-Astal HI, Massad M, AlMatar M, Ekal H. Cellular functions of RNA-binding Motif protein 3 (RBM3): clues in hypothermia, cancer biology and apoptosis. Protein Pept Lett. 2016;23(9):828–35.

Article  CAS  PubMed  Google Scholar 

Bandyopadhayaya S, Ford B, Mandal CC. Cold-hearted: a case for cold stress in cancer risk. J Therm Biol. 2020;91: 102608.

Article  CAS  PubMed  Google Scholar 

Hirata K, Nagasaka T. Enhancement of calorigenic response to cold and to norepinephrine in physically trained rats. Jpn J Physiol. 1981;31(5):657–65.

Article  CAS  PubMed  Google Scholar 

Afsarian O, Shahir MH, Lourens A, Akhlaghi A, Lotfolahian H, Hoseini A, et al. Eggshell temperature manipulations during incubation and in ovo injection of thyroxine are associated with a decreased incidence of cold-induced ascites in broiler chickens. Poult Sci. 2018;97(1):328–36.

Article  CAS  PubMed  Google Scholar 

Shmakov DN, Nuzhny VP, Kibler NA, Kharin SN. Changes in total cholesterol and heart rate in normotensive and hypertensive rats under combined influence of cold exposure and hypokinesia. Bull Exp Biol Med. 2020;169(6):738–41.

Article  CAS  PubMed  Google Scholar 

Zareei E, Karami F, Gholami M, Ershadi A, Avestan S, Aryal R, et al. Physiological and biochemical responses of strawberry crown and leaf tissues to freezing stress. BMC Plant Biol. 2021;21(1):532.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi H, Tan SJ, Zhong H, Hu W, Levine A, Xiao CJ, et al. Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia. Am J Hum Genet. 2009;84(4):534–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

So CL, Milevskiy MJG, Monteith GR. Transient receptor potential cation channel subfamily V and breast cancer. Labor Investig. 2020;100(2):199–206.

Article  CAS  Google Scholar 

Wang Y, Yin S, Mei L, Yang Y, Xu S, He X, et al. A dual receptors-targeting and size-switchable “cluster bomb” co-loading chemotherapeutic and transient receptor potential ankyrin 1 (TRPA-1) inhibitor for treatment of triple negative breast cancer. J Controll Release. 2020;321:71–83.

Article  CAS  Google Scholar 

Zhan C, Shi Y. TRPC channels and cell proliferation. Adv Exp Med Biol. 2017;976:149–55.

Article  CAS  PubMed  Google Scholar 

Lin R, Bao X, Wang H, Zhu S, Liu Z, Chen Q, et al. TRPM2 promotes pancreatic cancer by PKC/MAPK pathway. Cell Death Dis. 2021;12(6):585.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santoni G, Farfariello V. TRP channels and cancer: new targets for diagnosis and chemotherapy. Endocr Metab Immune Disord Drug Targets. 2011;11(1):54–67.

Article  CAS  PubMed  Google Scholar 

Kärki T, Tojkander S. TRPV protein family-from mechanosensing to cancer invasion. Biomolecules. 2021;11(7):1019.

Article  PubMed  PubMed Central  Google Scholar