Keywords
Kpuu, Hepatic bioavailability
Liver to blood ratio
Protein binding
AbbreviationsCBlood
steady-state concentration of total drug in blood
CBlood,u
steady-state concentration of unbound drug in blood
CH
steady-state concentration of total drug in the liver
CH,u
steady-state concentration of unbound drug in the liver
Cin
blood concentration entering the liver
Cout and CHepatic vein
blood concentration exiting the liver
CLBlood,u
unbound blood clearance
CLH,u
hepatic clearance determined based on systemic unbound concentrations
CLint
intrinsic hepatic clearance
CLLiver,u
hepatic clearance based on unbound liver concentrations
ECCS
Extended Clearance Classification System
ECM
Extended Clearance Model
ER
hepatic extraction ratio
FH
hepatic bioavailability
fuB
fraction of drug unbound in the blood
Kpss
Li & Jusko ratio at steady-state of total liver drug concentration to total drug concentration exiting the liver
Kpss,uu, Li & Jusko
ratio at steady-state of unbound liver drug concentration to unbound drug concentration exiting the liver
Kpuu
in vivo ratio at steady-state of unbound liver drug concentration to unbound systemic blood concentration
PSefflux
intrinsic basolateral efflux clearance
PSinflux
intrinsic basolateral influx clearance
© 2024 The Author(s). Published by Elsevier B.V.
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