Kpuu, Hepatic bioavailability
Liver to blood ratio
Protein binding
AbbreviationsCBloodsteady-state concentration of total drug in blood
CBlood,usteady-state concentration of unbound drug in blood
CHsteady-state concentration of total drug in the liver
CH,usteady-state concentration of unbound drug in the liver
Cinblood concentration entering the liver
Cout and CHepatic veinblood concentration exiting the liver
CLBlood,uunbound blood clearance
CLH,uhepatic clearance determined based on systemic unbound concentrations
CLintintrinsic hepatic clearance
CLLiver,uhepatic clearance based on unbound liver concentrations
ECCSExtended Clearance Classification System
ECMExtended Clearance Model
ERhepatic extraction ratio
FHhepatic bioavailability
fuBfraction of drug unbound in the blood
KpssLi & Jusko ratio at steady-state of total liver drug concentration to total drug concentration exiting the liver
Kpss,uu, Li & Juskoratio at steady-state of unbound liver drug concentration to unbound drug concentration exiting the liver
Kpuuin vivo ratio at steady-state of unbound liver drug concentration to unbound systemic blood concentration
PSeffluxintrinsic basolateral efflux clearance
PSinfluxintrinsic basolateral influx clearance
© 2024 The Author(s). Published by Elsevier B.V.
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