Long non-coding RNA DANCR increases spinal cord neuron apoptosis and inflammation of spinal cord injury by mediating the microRNA-146a-5p/MAPK6 axis

Anjum A, Yazid MD, Fauzi Daud M, Idris J, Ng AMH, Selvi Naicker A, Ismail OHR, Athi Kumar RK, Lokanathan Y (2020) Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci. https://doi.org/10.3390/ijms21207533

Article  PubMed  PubMed Central  Google Scholar 

Karsy M, Hawryluk G (2019) Modern medical management of spinal cord injury. Curr Neurol Neurosci Rep 19:65. https://doi.org/10.1007/s11910-019-0984-1

Article  CAS  PubMed  Google Scholar 

Liu X, Zhang Y, Wang Y, Qian T (2021) Inflammatory response to spinal cord injury and its treatment. World Neurosurg 155:19–31. https://doi.org/10.1016/j.wneu.2021.07.148

Article  PubMed  Google Scholar 

Zhou Y, Yu F (2021) Emerging roles of long non-coding RNAs in spinal cord injury. J Orthop Surg (Hong Kong) 29:23094990211030696. https://doi.org/10.1177/23094990211030698

Article  PubMed  Google Scholar 

Wang F, Liu J, Wang X, Chen J, Kong Q, Ye B, Li Z (2019) The emerging role of lncRNAs in spinal cord injury. Biomed Res Int 2019:3467121. https://doi.org/10.1155/2019/3467121

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thin KZ, Liu X, Feng X, Raveendran S, Tu JC (2018) LncRNA-DANCR: a valuable cancer related long non-coding RNA for human cancers. Pathol Res Pract 214:801–805. https://doi.org/10.1016/j.prp.2018.04.003

Article  CAS  PubMed  Google Scholar 

Wang Z, Zhong C, Cao Y, Yin H, Shen G, Lu W, Ding W (2021) LncRNA DANCR improves the dysfunction of the intestinal barrier and alleviates epithelial injury by targeting the miR-1306-5p/PLK1 axis in sepsis. Cell Biol Int 45:1935–1944. https://doi.org/10.1002/cbin.11633

Article  CAS  PubMed  Google Scholar 

Zhang L, Zhang P, Sun X, Zhou L, Zhao J (2018) Long non-coding RNA DANCR regulates proliferation and apoptosis of chondrocytes in osteoarthritis via miR-216a-5p-JAK2-STAT3 axis. Biosci Rep. https://doi.org/10.1042/BSR20181228

Dong J, Lu M, He X, Xu J, Qin J, Cheng Z, Liang B, Wang D, Li H (2014) Identifying the role of microRNAs in spinal cord injury. Neurol Sci 35:1663–1671. https://doi.org/10.1007/s10072-014-1940-0

Article  PubMed  Google Scholar 

Deng ZZ, Chen YH (2023) Research progress of MicroRNAs in spinal cord injury. J Integr Neurosci 22:31. https://doi.org/10.31083/j.jin2202031

Article  PubMed  Google Scholar 

Paim LR, Schreiber R, de Rossi G, Matos-Souza JR, Costa ESAA, Calegari DR, Cheng S, Marques FZ, Sposito AC, Gorla JI, Cliquet A Jr, Nadruz W Jr (2019) Circulating microRNAs, vascular risk, and physical activity in spinal cord-injured subjects. J Neurotrauma 36:845–852. https://doi.org/10.1089/neu.2018.5880

Article  PubMed  Google Scholar 

Lu Y, Cao DL, Jiang BC, Yang T, Gao YJ (2015) MicroRNA-146a-5p attenuates neuropathic pain via suppressing TRAF6 signaling in the spinal cord. Brain Behav Immun 49:119–129. https://doi.org/10.1016/j.bbi.2015.04.018

Article  CAS  PubMed  Google Scholar 

Lai X, Wang Y, Wang X, Liu B, Rong L (2022) miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes. Stem Cell Res Ther 13:487. https://doi.org/10.1186/s13287-022-03116-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hua T, Yang M, Song H, Kong E, Deng M, Li Y, Li J, Liu Z, Fu H, Wang Y, Yuan H (2022) Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p/TRAF6 axis. J Nanobiotechnology 20:324. https://doi.org/10.1186/s12951-022-01522-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Su Z, Liu HL, Li L, Wei M, Ge DJ, Zhang ZJ (2018) Effects of miR-26a-5p on neuropathic pain development by targeting MAPK6 in in CCI rat models. Biomed Pharmacother 107:644–649. https://doi.org/10.1016/j.biopha.2018.08.005

Article  CAS  PubMed  Google Scholar 

Yao T, Zha D, Hu C, Wu X (2020) Circ_0000285 promotes podocyte injury through sponging miR-654-3p and activating MAPK6 in diabetic nephropathy. Gene 747:144661. https://doi.org/10.1016/j.gene.2020.144661

Article  CAS  PubMed  Google Scholar 

Pang Y, Luo D, Wang S (2022) miR-128-3p inhibits the inflammation by targeting MAPK6 in penicillin-induced astrocytes. NeuroReport 33:742–749. https://doi.org/10.1097/WNR.0000000000001840

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ju C, Ma Y, Zuo X, Wang X, Song Z, Zhang Z, Zhu Z, Li X, Liang Z, Ding T, Hu X, Wang Z (2023) Photobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis. Cell Mol Biol Lett 28:5. https://doi.org/10.1186/s11658-023-00417-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang XM, Zeng LN, Yang WY, Ding L, Chen KZ, Fu WJ, Zeng SQ, Liang YR, Chen GH, Wu HF (2022) Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury. Neural Regen Res 17:217–227. https://doi.org/10.4103/1673-5374.314322

Article  CAS  PubMed  Google Scholar 

Shao R, Li C, Chen Y, Zhang L, Yang H, Zhang Z, Yue J, Gao W, Zhu H, Pan H, Zhou H, Quan R (2021) LncRNA-GAS5 promotes spinal cord repair and the inhibition of neuronal apoptosis via the transplantation of 3D printed scaffold loaded with induced pluripotent stem cell-derived neural stem cells. Ann Transl Med 9:931. https://doi.org/10.21037/atm-21-2570

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao Y, Zhang X, Xu J, Gao F, Wu Y, Cui X, Wei L, Jiang J, Wang X (2022) circ_014260/miR-384/THBS1 aggravates spinal cord injury in rats by promoting neuronal apoptosis and endoplasmic reticulum stress. Am J Transl Res 14:518–533

CAS  PubMed  PubMed Central  Google Scholar 

Jiao G, Pan B, Zhou Z, Zhou L, Li Z, Zhang Z (2015) MicroRNA-21 regulates cell proliferation and apoptosis in H(2)O(2)-stimulated rat spinal cord neurons. Mol Med Rep 12:7011–7016. https://doi.org/10.3892/mmr.2015.4265

Article  CAS  PubMed  Google Scholar 

Huang Y, Lin J, Chen X, Lin J (2021) Pannexin-1 contributes to the apoptosis of spinal neurocytes in spinal cord injury. Front Physiol 12:656647. https://doi.org/10.3389/fphys.2021.656647

Article  PubMed  PubMed Central  Google Scholar 

Yao Y, Sun F, Lei M (2018) miR-25 inhibits sepsis-induced cardiomyocyte apoptosis by targetting PTEN. Biosci Rep. https://doi.org/10.1042/BSR20171511

Eckert MJ, Martin MJ (2017) Trauma: spinal cord injury. Surg Clin North Am 97:1031–1045. https://doi.org/10.1016/j.suc.2017.06.008

Article  PubMed  Google Scholar 

Freyermuth-Trujillo X, Segura-Uribe JJ, Salgado-Ceballos H, Orozco-Barrios CE, Coyoy-Salgado A (2022) Inflammation: a target for treatment in spinal cord injury. Cells. https://doi.org/10.3390/cells11172692

Article  PubMed  PubMed Central  Google Scholar 

Zhang X, Ma L, Zhang C, Hou B, Zhou Y, Yu S (2021) Silencing LncRNA-DANCR attenuates inflammation and DSS-induced endothelial injury through miR-125b-5p. Gastroenterol Hepatol 44:644–653. https://doi.org/10.1016/j.gastrohep.2020.10.008

Article  PubMed  Google Scholar 

Zhang R, Hao Y, Zhang J (2022) The lncRNA DANCR promotes development of atherosclerosis by regulating the miR-214-5p/COX20 signaling pathway. Cell Mol Biol Lett 27:15. https://doi.org/10.1186/s11658-022-00310-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruan Y, Li H, Cao X, Meng S, Jia R, Pu L, Fu H, Jin Z (2021) Inhibition of the lncRNA DANCR attenuates cardiomyocyte injury induced by oxygen-glucose deprivation via the miR-19a-3p/MAPK1 axis. Acta Biochim Biophys Sin (Shanghai) 53:1377–1386. https://doi.org/10.1093/abbs/gmab110

Article  CAS  PubMed  Google Scholar 

Zhang M, Tang M, Wu Q, Wang Z, Chen Z, Ding H, Hu X, Lv X, Zhao S, Sun J, Kang S, Wu T, Xiao B (2020) LncRNA DANCR attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through regulating of miR-33a-5p/XBP1s. Aging (Albany NY) 12:1778–1791. https://doi.org/10.18632/aging.102712

Article  CAS  PubMed  Google Scholar 

Ni S, Yang B, Xia L, Zhang H (2021) EZH2 mediates miR-146a-5p/HIF-1alpha to alleviate inflammation and glycolysis after acute spinal cord injury. Mediat Inflamm 2021:5591582. https://doi.org/10.1155/2021/5591582

Article  CAS  Google Scholar 

He Y, Lv B, Huan Y, Liu B, Li Y, Jia L, Qu C, Wang D, Yu H, Yuan H (2018) Zhenbao pill protects against acute spinal cord injury via miR-146a-5p regulating the expression of GPR17. Biosci Rep. https://doi.org/10.1042/BSR20171132

Pham TL, Yin Y, Kwon HH, Shin N, Kim SI, Park H, Shin J, Shin HJ, Hwang JA, Song HJ, Kim SR, Lee JH, Hwang PTJ, Jun HW, Kim DW (2020) miRNA 146a–5p-loaded poly(d, l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia. Nanomedicine (Lond) 15:1113–1126. https://doi.org/10.2217/nnm-2019-0462

Article  CAS  PubMed  Google Scholar 

Huang ZQ, Xu W, Wu JL, Lu X, Chen XM (2019) MicroRNA-374a protects against myocardial ischemia-reperfusion injury in mice by targeting the MAPK6 pathway. Life Sci 232:116619. https://doi.org/10.1016/j.lfs.2019.116619

Article  CAS  PubMed  Google Scholar 

Wang R, Xu B (2021) TGF-beta1-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6. Cell Tissue Res 384:113–127. https://doi.org/10.1007/s00441-020-03

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