Exosomes from senescent epithelial cells activate pulmonary fibroblasts via the miR-217-5p/Sirt1 axis in paraquat-induced pulmonary fibrosis

Dinis-Oliveira RJ, Duarte JA, Sánchez-Navarro A, Remião F, Bastos ML, Carvalho F. Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol. 2008;38:13–71.

Article  CAS  PubMed  Google Scholar 

Kervégant M, Merigot L, Glaizal M, Schmitt C, Tichadou L, de Haro L. Paraquat poisonings in France during the European ban: experience of the poison control center in Marseille. J Med Toxicol. 2013;9:144–7.

Article  PubMed  PubMed Central  Google Scholar 

Bang YJ, Kim J, Lee WJ. Paraquat use among farmers in Korea after the ban. Arch Environ Occup Health. 2017;72:231–4.

Article  CAS  PubMed  Google Scholar 

Chen F, Ye Y, Jin B, Yi B, Wei Q, Liao L. Homicidal paraquat poisoning. J Forensic Sci. 2019;64:941–5.

Article  PubMed  Google Scholar 

Weng CH, Hu CC, Lin JL, Lin-Tan DT, Hsu CW, Yen TH. Predictors of acute respiratory distress syndrome in patients with paraquat intoxication. PLoS ONE. 2013;8: e82695.

Article  PubMed  PubMed Central  Google Scholar 

Sun B, Chen YG. Advances in the mechanism of paraquat-induced pulmonary injury. Eur Rev Med Pharmacol Sci. 2016;20:1597–602.

CAS  PubMed  Google Scholar 

Barkauskas CE, Noble PW. Cellular mechanisms of tissue fibrosis. 7. new insights into the cellular mechanisms of pulmonary fibrosis. Am J Physiol Cell Physiol. 2014;306:987–96.

Article  Google Scholar 

Cui L, Chen SY, Lerbs T, Lee JW, Domizi P, Gordon S, Kim YH, Nolan G, Betancur P, Wernig G. Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity. Nat Commun. 2020;11:2795.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baum J, Duffy HS. Fibroblasts and myofibroblasts: what are we talking about? J Cardiovasc Pharmacol. 2011;57:376–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, et al. Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017;127:3675–88.

Article  PubMed  PubMed Central  Google Scholar 

Huang C, Xue X, Gong N, Jiang J. Ginsenoside Rg1 suppresses paraquat-induced epithelial cell senescence by enhancing autophagy in an ATG12-dependent manner. Environ Toxicol. 2022;37:2302–13.

Article  CAS  PubMed  Google Scholar 

King TE Jr, Pardo A, Selman M. Idiopathic pulmonary fibrosis. Lancet. 2011;378:1949–61.

Article  PubMed  Google Scholar 

Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, et al. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011;300:L391-401.

Article  CAS  PubMed  Google Scholar 

Selman M, Pardo A. Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis an integral model. Am J Respir Crit Care Med. 2014;189:1161–72.

Article  CAS  PubMed  Google Scholar 

Isaac R, Reis FCG, Ying W, Olefsky JM. Exosomes as mediators of intercellular crosstalk in metabolism. Cell Metab. 2021;33:1744–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Ni YQ, Xu H, Xiang QY, Zhao Y, Zhan JK, He JY, Li S, Liu YS. Roles and mechanisms of exosomal non-coding RNAs in human health and diseases. Signal Transduct Target Ther. 2021;6:383.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fujita Y, Kadota T, Araya J, Ochiya T, Kuwano K. Extracellular vesicles: new players in lung immunity. Am J Respir Cell Mol Biol. 2018;58:560–5.

Article  CAS  PubMed  Google Scholar 

Makiguchi T, Yamada M, Yoshioka Y, Sugiura H, Koarai A, Chiba S, Fujino N, Tojo Y, Ota C, Kubo H, et al. Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis. Respir Res. 2016;17:110.

Article  PubMed  PubMed Central  Google Scholar 

Gao F, Zhang Y, Yang Z, Wang M, Zhou Z, Zhang W, Ren Y, Han X, Wei M, Sun Z, Nie S. Arctigenin suppressed epithelial-mesenchymal transition through Wnt3a/β-catenin pathway in PQ-induced pulmonary fibrosis. Front Pharmacol. 2020;11: 584098.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koide T, Mandai S, Kitaoka R, Matsuki H, Chiga M, Yamamoto K, Yoshioka K, Yagi Y, Suzuki S, Fujiki T, et al. Circulating extracellular vesicle-propagated microRNA signature as a vascular calcification factor in chronic kidney disease. Circ Res. 2023;132:415–31.

Article  CAS  PubMed  Google Scholar 

Chen X, Xu H, Hou J, Wang H, Zheng Y, Li H, Cai H, Han X, Dai J. Epithelial cell senescence induces pulmonary fibrosis through Nanog—mediated fibroblast activation. Aging. 2019;12:242–59.

Article  PubMed  PubMed Central  Google Scholar 

Greening DW, Xu R, Ji H, Tauro BJ, Simpson RJ. A protocol for exosome isolation and characterization: evaluation of ultracentrifugation, density-gradient separation, and immunoaffinity capture methods. Methods Mol Biol. 2015;1295:179–209.

Article  CAS  PubMed  Google Scholar 

Chevillet JR, Kang Q, Ruf IK, Briggs HA, Vojtech LN, Hughes SM, Cheng HH, Arroyo JD, Meredith EK, Gallichotte EN, et al. Quantitative and stoichiometric analysis of the microRNA content of exosomes. Proc Natl Acad Sci USA. 2014;111:14888–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barnes PJ, Baker J, Donnelly LE. Cellular senescence as a mechanism and target in chronic lung diseases. Am J Respir Crit Care Med. 2019;200:556–64.

Article  CAS  PubMed  Google Scholar 

Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome—mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9:654–9.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Li T, Pan M, Wang W, Huang W, Yuan Y, Xie Z, Chen Y, Peng J, Li X, Meng Y. SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism. J Transl Med. 2022;20:222.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu HH, Cao G, Wu XQ, Vaziri ND, Zhao YY. Wnt signaling pathway in aging-related tissue fibrosis and therapies. Ageing Res Rev. 2020;60: 101063.

Article  CAS  PubMed  Google Scholar 

Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trend Cell Biol. 2014;24:464–71.

Article  CAS  Google Scholar 

Gawarammana IB, Buckley NA. Medical management of paraquat ingestion. Br J Clin Pharmacol. 2011;72:745–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A. Cellular senescence: aging, cancer, and injury. Physiol Rev. 2019;99:1047–78.

Article  CAS  PubMed  Google Scholar 

Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM. Senescence and apoptosis: dueling or complementary cell fates? EMBO Rep. 2014;15:1139–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hernandez-Segura A, Nehme J, Demaria M. Hallmarks of cellular senescence. Trend Cell Biol. 2018;28:436–53.

Article  CAS  Google Scholar 

Liu X, Miao J, Wang C, Zhou S, Chen S, Ren Q, Hong X, Wang Y, Hou FF, Zhou L, Liu Y. Tubule-derived exosomes play a central role in fibroblast activation and kidney fibrosis. Kidney Int. 2020;97:1181–95.

Article  CAS  PubMed  Google Scholar 

Pegtel DM, Gould SJ. Exosomes. Annu Rev Biochem. 2019;88:487–514.

Article  CAS  PubMed  Google Scholar 

He C, Zheng S, Luo Y, Wang B. Exosome theranostics: biology and translational medicine. Theranostics. 2018;8:237–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu X, Odenthal M, Fries JW. Exosomes as miRNA carriers: formation-function-future. Int J Mol Sci. 2016. https://doi.org/10.3390/ijms17122028.

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