Bajitianwan formula extract ameliorates bone loss induced by iron overload via activating RAGE/PI3K/AKT pathway based on network pharmacology and transcriptomic analysis

Miller PD (2016) Management of severe osteoporosis. Expert Opin Pharmacother 17(4):473–488. https://doi.org/10.1517/14656566.2016.1124856

Article  CAS  PubMed  Google Scholar 

Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y (2016) Regulators of iron homeostasis: new players in metabolism, cell death, and disease. Trends Biochem Sci 41(3):274–286. https://doi.org/10.1016/j.tibs.2015.11.012

Article  CAS  PubMed  Google Scholar 

Che J, Yang J, Zhao B, Zhang G, Wang L, Peng S et al (2020) The effect of abnormal iron metabolism on osteoporosis. Biol Trace Elem Res 195(2):353–365. https://doi.org/10.1007/s12011-019-01867-4

Article  CAS  PubMed  Google Scholar 

França M, Martí-Bonmatí L, Porto G, Silva S, Guimarães S, Alberich-Bayarri Á et al (2018) Tissue iron quantification in chronic liver diseases using MRI shows a relationship between iron accumulation in liver, spleen, and bone marrow. Clin Radiol 73(2):211–215. https://doi.org/10.1016/j.crad.2017.07.022

Article  Google Scholar 

Zeidan RS, Han SM, Leeuwenburgh C, Xiao R (2021) Iron homeostasis and organismal aging. Ageing Res Rev 72:101510. https://doi.org/10.1016/j.arr.2021.101510

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang W, Jing X, Du T, Ren J, Liu X, Chen F et al (2022) Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes. Free Radic Biol Med 190:234–246. https://doi.org/10.1016/j.freeradbiomed.2022.08.018

Article  CAS  PubMed  Google Scholar 

Mukwaya E, Xu F, Wong MS, Zhang Y (2014) Chinese herbal medicine for bone health. Pharm Biol 52(9):1223–1228. https://doi.org/10.3109/13880209.2014.884606

Article  PubMed  Google Scholar 

Peng H (1994) Dictionary of traditional chinese medicine prescriptions. Second ed. People's Medical Publishing House Co., Ltd., China, pp 1994.

Xia T, Dong X, Lin L, Jiang Y, Ma X, Xin H et al (2019) Metabolomics profiling provides valuable insights into the underlying mechanisms of Morinda officinalis on protecting glucocorticoid-induced osteoporosis. J Pharm Biomed Anal 166:336–346. https://doi.org/10.1016/j.jpba.2019.01.019

Article  CAS  PubMed  Google Scholar 

Arring NM, Millstine D, Marks LA, Nail LM (2018) Ginseng as a treatment for fatigue: a systematic review. J Altern Complement Med 24(7):624–633. https://doi.org/10.1089/acm.2017.0361

Article  PubMed  Google Scholar 

Lee B, Hong S, Kim M, Kim EY, Park HJ, Jung HS, et al (2021) Lycii radicis cortex inhibits glucocorticoid‑induced bone loss by downregulating Runx2 and BMP‑2 expression. Int J Mol Med 48(2). https://doi.org/10.3892/ijmm.2021.4988.

Zhang H, Han T, Zhang L, Yu CH, Wan DG, Rahman K et al (2008) Effects of tenuifolin extracted from radix polygalae on learning and memory: a behavioral and biochemical study on aged and amnesic mice. Phytomedicine 15(8):587–594. https://doi.org/10.1016/j.phymed.2007.12.004

Article  CAS  PubMed  Google Scholar 

Wen J, Yang Y, Hao J (2023) Acori Tatarinowii Rhizoma: A comprehensive review of its chemical composition, pharmacology, pharmacokinetics and toxicity. Front Pharmacol 14:1090526. https://doi.org/10.3389/fphar.2023.1090526

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu T, Zhang H, Wang S, Xiang Z, Kong H, Xue Q et al (2022) A review on the advances in the extraction methods and structure elucidation of Poria cocos polysaccharide and its pharmacological activities and drug carrier applications. Int J Biol Macromol 217:536–551. https://doi.org/10.1016/j.ijbiomac.2022.07.070

Article  CAS  PubMed  Google Scholar 

Lin H, He J (2019) Effects of Bajitianwan on the expression of RANK, NFAT2 and V-ATP mRNA in the bone of ovariectomized rats. World J Integrated Traditional Western Med 6(14): 802–804. https://doi.org/10.13935/j.cnki.sjzx.190615.

Lin H, He J (2019) Clinical observation on the treatment of spleen kidney yang deficiency of senile osteoporosis with Bajitianwan. Guangming Traditional Chin Med 1(34):45–47. https://doi.org/10.3969/j.issn.1003-8914.2019.01.019

Article  Google Scholar 

Xu W, Liu X, He X, Jiang Y, Zhang J, Zhang Q et al (2020) Bajitianwan attenuates D-galactose-induced memory impairment and bone loss through suppression of oxidative stress in aging rat model. J Ethnopharmacol 261:112992. https://doi.org/10.1016/j.jep.2020.112992

Article  CAS  PubMed  Google Scholar 

Chen B, Li GF, Shen Y, Huang XI, Xu YJ (2015) Reducing iron accumulation: a potential approach for the prevention and treatment of postmenopausal osteoporosis. Exp Ther Med 10(1):7–11. https://doi.org/10.3892/etm.2015.2484

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu LL, Liu GW, Liu H, Zhao K, Xu YJ (2021) Iron accumulation deteriorated bone loss in estrogen-deficient rats. J Orthop Surg Res 16(1):525. https://doi.org/10.1186/s13018-021-02663-4

Article  PubMed  PubMed Central  Google Scholar 

Li S, Zhang B (2013) Traditional Chinese medicine network pharmacology: theory, methodology and application. Chin J Nat Med 11(2):110–120. https://doi.org/10.1016/S1875-5364(13)60037-0

Article  PubMed  Google Scholar 

Cai FF, Zhou WJ, Wu R, Su SB (2018) Systems biology approaches in the study of Chinese herbal formulae. Chin Med 13:65. https://doi.org/10.1186/s13020-018-0221-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

XU S, Xia T, Zhang J, Jiang Y, Wang N, Xin H, et al (2022) Protective effects of bitter acids from Humulus lupulus L. against senile osteoporosis via activating Nrf2/HO-1/NQO1 pathway in D-galactose induced aging mice. J Funct Foods 94: 105099. https://doi.org/10.1016/j.jff.2022.105099.

Zhang W, Huai Y, Miao Z, Qian A, Wang Y (2019) Systems pharmacology for investigation of the mechanisms of action of traditional chinese medicine in drug discovery. Front Pharmacol 10:743. https://doi.org/10.3389/fphar.2019.00743

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan YS, Li Q, Hamdan N, Bian YF, Zhuang S, Fan K, et al (2018) Tetrahydroxystilbene glucoside regulates proliferation, differentiation, and OPG/RANKL/M-CSF expression in MC3T3-E1 Cells via the PI3K/Akt pathway. Molecules 23(9). https://doi.org/10.3390/molecules23092306.

Gao Z, Chen Z, Xiong Z, Liu X (2022) Ferroptosis—a new target of osteoporosis. Exp Gerontol 165:111836. https://doi.org/10.1016/j.exger.2022.111836

Article  CAS  PubMed  Google Scholar 

Antoniucci DM, Sellmeyer DE, Bilezikian JP, Palermo L, Ensrud KE, Greenspan SL (2007) Elevations in serum and urinary calcium with parathyroid hormone (1–84) with and without alendronate for osteoporosis. J Clin Endocrinol Metab 92(3):942–947. https://doi.org/10.1210/jc.2006-1788

Article  CAS  PubMed  Google Scholar 

Sun X, Xia T, Zhang S, Zhang J, Xu L, Han T (2022) Hops extract and xanthohumol ameliorate bone loss induced by iron overload via activating Akt/GSK3beta/Nrf2 pathway. J Bone Miner Metab 40(3):375–388. https://doi.org/10.1007/s00774-021-01295-2

Article  CAS  PubMed  Google Scholar 

Xu G, Li X, Zhu Z, Wang H, Bai X (2021) Iron overload induces apoptosis and cytoprotective autophagy regulated by ROS generation in Mc3t3-E1 cells. Biol Trace Elem Res 199(10):3781–3792. https://doi.org/10.1007/s12011-020-02508-x

Article  CAS  PubMed  Google Scholar 

Weng Y, Wang H, Li L, Feng Y, Xu S, Wang Z (2021) Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment. Redox Biol 40:101849. https://doi.org/10.1016/j.redox.2020.101849

Article  CAS  PubMed  Google Scholar 

Peng P, Nie Z, Sun F, Peng H (2021) Glucocorticoids induce femoral head necrosis in rats through the ROS/JNK/c-Jun pathway. FEBS Open Bio 11(1):312–321. https://doi.org/10.1002/2211-5463.13037

Article  CAS  PubMed  Google Scholar 

Li M, Xing X, Huang H, Liang C, Gao X, Tang Q et al (2022) BMSC-derived ApoEVs promote craniofacial bone repair via ROS/JNK signaling. J Dent Res 101(6):714–723. https://doi.org/10.1177/00220345211068338

Article  CAS  PubMed  Google Scholar 

Cai FF, Bian YQ, Wu R, Sun Y, Chen XL, Yang MD et al (2019) Yinchenhao decoction suppresses rat liver fibrosis involved in an apoptosis regulation mechanism based on network pharmacology and transcriptomic analysis. Biomed Pharmacother 114:108863. https://doi.org/10.1016/j.biopha.2019.108863

Article  CAS  PubMed  Google Scholar 

Gao F, Niu Y, Sun L, Li W, Xia H, Zhang Y et al (2022) Integrating network pharmacology and transcriptomic validation to investigate the efficacy and mechanism of Mufangji decoction preventing lung cancer. J Ethnopharmacol 298:115573. https://doi.org/10.1016/j.jep.2022.115573

Article  CAS  PubMed  Google Scholar 

Cheng YZ, Yang SL, Wang JY, Ye M, Zhuo XY, Wang LT et al (2018) Irbesartan attenuates advanced glycation end products-mediated damage in diabetes-associated osteoporosis through the AGEs/RAGE pathway. Life Sci 205:184–192. https://doi.org/10.1016/j.lfs.2018.04.042

Article  CAS  PubMed  Google Scholar 

Cheng Y, Liu P, Xiang Q, Liang J, Chen H, Zhang H et al (2022) Glucagon-like peptide-1 attenuates diabetes-associated osteoporosis in ZDF rat, possibly through the RAGE pathway. BMC Musculoskelet Disord 23(1):465. https://doi.org/10.1186/s12891-022-05396-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Francisqueti-Ferron FV, Ferron AJT, Altomare A, Garcia JL, Moreto F, Ferreira ALA et al (2021) Gamma-oryzanol reduces renal inflammation and oxidative stress by modulating AGEs/RAGE axis in animals submitted to high sugar-fat diet. J Bras Nefrol 43(4):460–469. https://doi.org/10.1590/2175-8239-JBN-2021-0002

Article  PubMed  PubMed Central 

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