Akhigbe, R. E., Aminat, B. O., Akhigbe, T. M., & Hamed, M. A. (2024). Glutamine alleviates I/R-induced intestinal injury and dysmotility via the downregulation of Xanthine Oxidase/Uric acid signaling and lactate generation in Wistar rats. Journal of Surgical Research, 295, 431–441.

Article  CAS  PubMed  Google Scholar 

Afolabi, A. O., Akhigbe, T. M., Odetayo, A. F., Anyogu, D. C., Hamed, M. A., & Akhigbe, R. E. (2022). Restoration of hepatic and intestinal integrity by Phyllanthus amarus is dependent on Bax/caspase 3 modulation in intestinal ischemia-/reperfusion-induced injury. Molecules, 27(16), 5073.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Afolabi, O. A., Akhigbe, T. M., Akhigbe, R. E., Alabi, B. A., Gbolagun, O. T., Taiwo, M. E., Fakeye, O. O., & Yusuf, E. O. (2022). Methanolic Moringa oleifera leaf extract protects against epithelial barrier damage and enteric bacterial translocation in intestinal I/R: Possible role of caspase 3. Frontiers in Pharmacology, 13, 989023.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, Y., Du, Y., Le, W., Wang, K., Kieffer, N., & Zhang, J. (2011). Redox control of the survival of healthy and diseased cells. Antioxidants & Redox Signaling, 15, 2867–2908.

Article  CAS  Google Scholar 

Piantadosi, C. A. (2008). Carbon monoxide, reactive oxygen signaling, and oxidative stress. Free Radical Biology and Medicine, 45, 562–569.

Article  CAS  PubMed  Google Scholar 

Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012). Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cellular Signalling., 24, 981–990.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vollmar, B., & Menger, M. D. (2011). Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences. Langenbecks Arch Surg, 396, 13–29.

Article  PubMed  Google Scholar 

Okudan, N., Belviranlı, M., Gökbel, H., Öz, M., & Kumak, A. (2013). Protective effects of curcumin supplementation on intestinal ischemia reperfusion injury. Phytomedicine, 20(10), 844–848.

Article  CAS  PubMed  Google Scholar 

Yurdakan, G., Tekin, I. O., Comert, M., Acikgoz, S., & Sipahi, E. Y. (2012). The presence of oxidized low-density lipoprotein and inducible nitric oxide synthase expression in renal damage after intestinal ischemia reperfusion. Kaohsiung Journal of Medical Science, 28, 16–22.

Article  CAS  Google Scholar 

Kazantzidou, D., Tsalis, K., & Vasiliadis, K., et al. (2010). Alanine-glutamine dipeptide pretreatment protects rat renal function from small intestine ischemia-reperfusion injury. Minerva Chir, 65, 515–525.

CAS  PubMed  Google Scholar 

Akhigbe, R. E., Hamed, M. A., & Aremu, A. O. (2021). HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content. Reproductive Toxicology, 103, 96–107.

Article  CAS  PubMed  Google Scholar 

Kang, D. H., Park, S. K., Lee, I. K., & Johnson, R. J. (2005). Uric acid–induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. Journal of the American Society of Nephrology, 16(12), 3553–3562.

Article  CAS  PubMed  Google Scholar 

Raish, M., Ahmad, A., Ansari, M. A., Alkharfy, K. M., Aljenoobi, F. I., Jan, B. L., Al-Mohizea, A. M., Khan, A., & Ali, N. (2018). Momordica charantia polysaccharides ameliorate oxidative stress, inflammation, and apoptosis in ethanol-induced gastritis in mucosa through NF-kB signaling pathway inhibition. International Journal of Biological Macromolecules, 111, 193–199.

Article  CAS  PubMed  Google Scholar 

Hamed, M. A., Akhigbe, T. M., Akhigbe, R. E., Aremu, A. O., Oyedokun, P. A., Gbadamosi, J. A., Anifowose, P. E., Adewole, M. A., Aboyeji, O. O., Yisau, H. O., & Tajudeen, G. O. (2022). Glutamine restores testicular glutathione-dependent antioxidant defense and upregulates NO/cGMP signaling in sleep deprivation-induced reproductive dysfunction in rats. Biomedicine & Pharmacotherapy, 148, 112765.

Article  CAS  Google Scholar 

Nur, E., Verwijs, M., de Waart, D. R., Schnog, J. J., Otten, H. M., Brandjes, D. P., Biemond, B. J., & Elferink, R. P., CURAMA Study Group. (2011). Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1812(11), 1412–1417.

Article  CAS  PubMed  Google Scholar 

Chiu, C. J., McArdle, A. H., Brown, R., Scott, H. J., & Gurd, F. N. (1970). Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Archives of Surgery, 101, 478–483.

Article  CAS  PubMed  Google Scholar 

Beutler, E., Duron, O., & Kelly, B. M. (1963). Improved method for the determination of blood glutathione. The Journal of Laboratory and Clinical Medicine, 61, 882–888.

CAS  PubMed  Google Scholar 

Fridovich, I., & Misra, H. P. (1972). The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. Journal of Biological Chemistry, 247, 3170–3175.

Article  PubMed  Google Scholar 

Euler, H. V., & Josephson, K. (1972). Uber katalase. European Journal of Organic Chemistry, 452, 158–181.

Google Scholar 

Perandones, C. E., Illera, V. A., Peckham, D., Stunz, L. L., & Ashman, R. F. (1993). Regulation of apoptosis in vitro in mature murine spleen T cells. Journal of Immunology, 151(7), 3521–3529.

Article  CAS  Google Scholar 

Hu X., Ma R., Lu J., Zhang K., Xu W., Jiang H., Da Y. IL–23 promotes myocardial I/ R injury by increasing the inflammatory responses and oxidative stress reactions. Cellular Physiology and Biochemistry 206; 38: 2163–2172

Yang, S.-H., & Liu, R. (2016). For the pursuit of oxygen and carbon dioxide channels in mitochondria. Medical Gas Research, 6, 237–238.

Article  PubMed  PubMed Central  Google Scholar 

Ezraty, B., Gennaris, A., Barras, F., & Collet, J. –F. (2017). Oxidative stress, protein damage and repair in bacteria. Nature Reviews Microbiology, 15, 385.

Article  CAS  PubMed  Google Scholar 

Oyedokun, P. A., Akhigbe, R. E., Ajayi, L. O., & Ajayi, A. F. (2023 Apr). Impact of hypoxia on male reproductive functions. Molecular and Cellular Biochemistry, 478(4), 875–885.

Article  CAS  PubMed  Google Scholar 

Biswas, R., & Bagchi A. (2016). NFkB pathway and inhibition: an overview. Computational Molecular Biology, (1), 6.

Barnes, P. J., & Karin, M. (1997). Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. The New England Journal of Medicine, 336, 1066–1071.

Article  CAS  PubMed  Google Scholar 

Baldwin, Jr, A. S. (1996). The NF-kappa B and I kappa B proteins: new discoveries and insights. The Annual Review of Immunology, 14, 649–683.

Article  CAS  PubMed  Google Scholar 

Clarysse, M., Accarie, A., Farré, R., Canovai, E., Monbaliu, D., Gunst, J., De Hertogh, G., Vanuytsel, T., Pirenne, J., & Ceulemans, L. J. (2023). Protective effect of oxygen and isoflurane in rodent model of intestinal ischemia-reperfusion injury. International Journal of Molecular Sciences, 24(3), 2587.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, R., Zeng, Z., & Zhang, Y.-Y., et al. (2020). Ischemic postconditioning attenuates acute kidney injury following intestinal ischemiareperfusion through Nrf2-regulated autophagy, anti-oxidation, and anti-inflammation in mice. The FASEB Journal, 34, 8887–8901.

Article  CAS  PubMed  Google Scholar 

Akhigbe, R. E., Ajayi, L. O., Adelakun, A. A., Olorunnisola, O. S., & Ajayi, A. F. (2020). Codeine-induced hepatic injury is via oxido-inflammatory damage and caspase-3-mediated apoptosis. Molecular Biology Reports, 47, 9521–9530.

Article  CAS  PubMed  Google Scholar 

Wallach, D., Varfolomeev, E. E., Malinin, N. L., Goltsev, Y. V., Kovalenko, A. V., & Boldin, M. P. (1999). Tumor necrosis factor receptor and Fas signaling mechanisms. The Annual Review of Immunology, 17, 331–367.

Article  CAS  PubMed  Google Scholar 

Yuan, J. (1997). Transducing signals of life and death. Current Opinion in Cell Biology, 9, 247–251.

Article  CAS  PubMed  Google Scholar 

Reed, J. C. (1997). Cytochrome c: can’t live with it; can’t live without it. Cell, 91, 559–562.

Article  CAS  PubMed  Google Scholar 

Green, D. R., & Reed, J. C. (1998). Mitochondria and apoptosis. Science, 281, 1309–1312.

Article  CAS  PubMed  Google Scholar 

Elmore, S. (2007). Apoptosis: A review of programmed cell death. Toxicologic Pathology, 35, 495–516.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amini, N., Maleki, M., & Badavi, M. (2022). Nephroprotective activity of naringin against chemical-induced toxicity and renal ischemia/reperfusion injury: A review. Avicenna Journal of Phytomedicine, 12(4), 357.

PubMed  PubMed Central  Google Scholar 

Amini, N., Sarkaki, A., Dianat, M., Mard, S. A., Ahangarpour, A., & Badavi, M. (2019). Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation. Pharmacological Reports, 71(6), 1059–1066.

Article  PubMed  Google Scholar 

Chiu, Y. W., Lee, C. H., & Lo, H. C. (2024). Oral post-treatment supplementation with a combination of glutamine, citrulline, and antioxidant vitamins additively mitigates jejunal damage, oxidative stress, and inflammation in rats with intestinal ischemia and reperfusion. Plos One, 19(2), e0298334 Feb 2.