Globally, colorectal cancer (CRC) is the third most common cancer after lung and breast cancer and the second cause of cancer-related death [1], [2]. Colorectal, prostate, and lung cancers account for 46% of all types of cancer in men. Breast, lung, and CRC cancers account for half of all new cancer diagnoses in females [3]. To date, the pathophysiology of CRC has remained a mystery. Risk factors have been identified as age, environment, a high-fat diet, and family history [4]. Cancer treatments include chemotherapy, radiation, and surgery. Chemotherapy and radiation are frequently associated with severe side effects and toxicity, significantly lowering patients' quality of life. Additionally, cancer cells may develop resistance to chemotherapy and radiation over time [5], [6], [7], [8]. As a result, effective new treatments for CRC are extremely necessary.

It is reported that numerous genes and pathways are involved in various stages and the development of cancers. Several important pathways, including apoptosis, inflammation, and cell cycle, are influenced by critical genes, and identifying these genes and pathways promises to aid scientists in curing cancers such as CRC [9], [10], [11]. Even in the era of newer lipid-lowering therapies [12], [13], [14], statins are the most widely prescribed and effective lipid-lowering agents available today [15], [16], [17]. Numerous studies have indicated that they inhibit HMG-CoA reductase and reduce the plasma levels of cholesterol-rich atherogenic lipoproteins [16], [18], [19]. Despite intolerance in a proportion of statins users [20], statins are generally safe and well tolerated. Additionally, statins exert various pleiotropic actions [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31] including anti-inflammatory [32], [33], [34], antioxidant [35], [36] and antithrombotic [37], [38]actions. According to accumulating research evidence, statins may also have an anti-carcinogenic effect [39], [40], [41], [42], [43]. Several metabolic pathways are regulated by statins, which explains their anticancer efficacy. Statins have an effect on cell growth, proliferation, migration, apoptosis, and survival by regulating several metabolic pathways [44], [45], [46], [47]. Those studies have shown the potential anticancer effect of statins in several cancers [48], [49], [50], [51]. Recent research has focused on the potential role of statins in the chemoprevention, incidence, and treatment of CRC [52]. While observational studies have suggested an association between statin use and lower cancer incidence, this relationship has not been fully proven in randomized controlled trials (RCTs). Ongoing research tries to close this gap and scrutinize the causality of this association. Furthermore, statins' precise mechanism of action on CRC is uncertain due to their unknown potential mechanisms. The purpose of this study was to determine the association between statin targets and differentially expressed genes associated with CRC in patient samples using bioinformatics analysis.