Alexander JL, Mullish BH, Danckert NP, Liu Z, Olbei ML, Saifuddin A, Torkizadeh M, Ibraheim H, Blanco JM, Roberts LA, Bewshea CM, Nice R, Lin S, Prabhudev H, Sands C, Horneffer-van der Sluis V, Lewis M, Sebastian S, Lees CW, Teare JP, Hart A, Goodhand JR, Kennedy NA, Korcsmaros T, Marchesi JR, Ahmad T, Powell N (2023) The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients. EBioMedicine 88:104430
Article CAS PubMed PubMed Central Google Scholar
Backhed F (2013) Meat-metabolizing bacteria in atherosclerosis. Nat Med 19:533–534
Blum M (2000) Ultrasonography of the Thyroid. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrere B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Shah AS, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP (eds) Endotext. South Dartmouth (MA)
Bogovic Crncic T, Ilic Tomas M, Girotto N, Grbac Ivankovic S (2020) Risk factors for thyroid cancer: what do we know so far? Acta Clin Croat 59:66–72
PubMed PubMed Central Google Scholar
Chan CWH, Law BMH, Waye MMY, Chan JYW, So WKW, Chow KM (2019) Trimethylamine-N-oxide as one hypothetical link for the relationship between intestinal microbiota and cancer—where we are and where shall we go? J Cancer 10:5874–5882
Article CAS PubMed PubMed Central Google Scholar
Dambrova M, Latkovskis G, Kuka J, Strele I, Konrade I, Grinberga S, Hartmane D, Pugovics O, Erglis A, Liepinsh E (2016) Diabetes is associated with higher trimethylamine N-oxide plasma levels. Exp Clin Endocrinol Diabetes 124:251–256
Article CAS PubMed Google Scholar
Deja S, Dawiskiba T, Balcerzak W, Orczyk-Pawilowicz M, Glod M, Pawelka D, Mlynarz P (2013) Follicular adenomas exhibit a unique metabolic profile. (1)H NMR studies of thyroid lesions. PLoS One 8:84637
Fagin JA, Wells SA Jr (2016) Biologic and clinical perspectives on thyroid cancer. N Engl J Med 375:1054–1067
Article CAS PubMed PubMed Central Google Scholar
Farrokhi Yekta R, Rezaei Tavirani M, Arefi Oskouie A, Mohajeri-Tehrani MR, Soroush AR, Akbarzadeh Baghban A (2018) Serum-based metabolic alterations in patients with papillary thyroid carcinoma unveiled by non-targeted 1H-NMR metabolomics approach. Iran J Basic Med Sci 21:1140–1147
PubMed PubMed Central Google Scholar
Gatarek P, Kaluzna-Czaplinska J (2021) Trimethylamine N-oxide (TMAO) in human health. EXCLI J 20:301–319
PubMed PubMed Central Google Scholar
Gharib H, Papini E, Garber JR, Duick DS, Harrell RM, Hegedus L, Paschke R, Valcavi R, Vitti P, Nodules AAATFoT (2016) American association of clinical endocrinologists, American college of endocrinology, and associazione medici endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules–2016 update. Endocr Pract 22:622–639
Ha EJ, Suh CH, Baek JH (2018) Complications following ultrasound-guided core needle biopsy of thyroid nodules: a systematic review and meta-analysis. Eur Radiol 28:3848–3860
Hamaya R, Ivey KL, Lee DH, Wang M, Li J, Franke A, Sun Q, Rimm EB (2020) Association of diet with circulating trimethylamine-N-oxide concentration. Am J Clin Nutr 112:1448–1455
Article PubMed PubMed Central Google Scholar
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L (2016) 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26:1–133
Article PubMed PubMed Central Google Scholar
Heianza Y, Ma W, Manson JE, Rexrode KM, Qi L (2017) Gut microbiota metabolites and risk of major adverse cardiovascular disease events and death: a systematic review and meta-analysis of prospective studies. J Am Heart Assoc. https://doi.org/10.1161/JAHA.116.004947
Article PubMed PubMed Central Google Scholar
Jalandra R, Dalal N, Yadav AK, Verma D, Sharma M, Singh R, Khosla A, Kumar A, Solanki PR (2021) Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer. Appl Microbiol Biotechnol 105:7651–7660
Article CAS PubMed Google Scholar
Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL (2013) Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 19:576–585
Article CAS PubMed PubMed Central Google Scholar
Li D, Lu Y, Yuan S, Cai X, He Y, Chen J, Wu Q, He D, Fang A, Bo Y, Song P, Bogaert D, Tsilidis K, Larsson SC, Yu H, Zhu H, Theodoratou E, Zhu Y, Li X (2022) Gut microbiota-derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis. Am J Clin Nutr 116:230–243
Article PubMed PubMed Central Google Scholar
Liu Q, Li B, Li Y, Wei Y, Huang B, Liang J, You Z, Li Y, Qian Q, Wang R, Zhang J, Chen R, Lyu Z, Chen Y, Shi M, Xiao X, Wang Q, Miao Q, Fang JY, Gershwin ME, Lian M, Ma X, Tang R (2022a) Altered faecal microbiome and metabolome in IgG4-related sclerosing cholangitis and primary sclerosing cholangitis. Gut 71:899–909
Liu X, Wong CKH, Chan WWL, Au ICH, Tang EHM, Lang BHH (2022b) Survival after hemithyroidectomy versus total thyroidectomy in non-high-risk differentiated thyroid cancer: population-based analysis. BJS Open. https://doi.org/10.1093/bjsopen/zrac146
Article PubMed PubMed Central Google Scholar
Mayers JR, Vander Heiden MG (2015) Famine versus feast: understanding the metabolism of tumors in vivo. Trends Biochem Sci 40:130–140
Article CAS PubMed PubMed Central Google Scholar
Miccoli P, Torregrossa L, Shintu L, Magalhaes A, Chandran J, Tintaru A, Ugolini C, Minuto MN, Miccoli M, Basolo F, Caldarelli S (2012) Metabolomics approach to thyroid nodules: a high-resolution magic-angle spinning nuclear magnetic resonance-based study. Surgery 152:1118–1124
Mirji G, Worth A, Bhat SA, El Sayed M, Kannan T, Goldman AR, Tang HY, Liu Q, Auslander N, Dang CV, Abdel-Mohsen M, Kossenkov A, Stanger BZ, Shinde RS (2022) The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer. Sci Immunol 7:0704
Mondul AM, Moore SC, Weinstein SJ, Karoly ED, Sampson JN, Albanes D (2015) Metabolomic analysis of prostate cancer risk in a prospective cohort: The alpha-tocolpherol, beta-carotene cancer prevention (ATBC) study. Int J Cancer 137:2124–2132
Article CAS PubMed PubMed Central Google Scholar
Oellgaard J, Winther SA, Hansen TS, Rossing P, von Scholten BJ (2017) Trimethylamine N-oxide (TMAO) as a new potential therapeutic target for insulin resistance and cancer. Curr Pharm Des 23:3699–3712
Article CAS PubMed Google Scholar
Perea-Gil I, Seeger T, Bruyneel AAN, Termglinchan V, Monte E, Lim EW, Vadgama N, Furihata T, Gavidia AA, Arthur Ataam J, Bharucha N, Martinez-Amador N, Ameen M, Nair P, Serrano R, Kaur B, Feyen DAM, Diecke S, Snyder MP, Metallo CM, Mercola M, Karakikes I (2022) Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy. Eur Heart J 43:3477–3489
Article CAS PubMed PubMed Central Google Scholar
Qiu S, Cai Y, Yao H, Lin C, Xie Y, Tang S, Zhang A (2023) Small molecule metabolites: discovery of biomarkers and therapeutic targets. Signal Transduct Target Ther 8:132
Article PubMed PubMed Central Google Scholar
Russ G, Bonnema SJ, Erdogan MF, Durante C, Ngu R, Leenhardt L (2017) European thyroid association guidelines for ultrasound malignancy risk stratification of thyroid nodules in adults: the EU-TIRADS. Eur Thyroid J 6:225–237
Article PubMed PubMed Central Google Scholar
Ryoo I, Kwon H, Kim SC, Jung SC, Yeom JA, Shin HS, Cho HR, Yun TJ, Choi SH, Sohn CH, Park S, Kim JH (2016) Metabolomic analysis of percutaneous fine-needle aspiration specimens of thyroid nodules: potential application for the preoperative diagnosis of thyroid cancer. Sci Rep 6:30075
Article ADS CAS PubMed PubMed Central Google Scholar
Sakorafas GH, Mastoraki A, Lappas C, Safioleas M (2010) Small (<10 mm) thyroid nodules; how aggressively should they be managed? Onkologie 33:61–64
Seiberling KA, Dutra JC, Gunn J (2008) Ultrasound-guided fine needle aspiration biopsy of thyroid nodules performed in the office. Laryngoscope 118:228–231
Seo H, Na DG, Kim JH, Kim KW, Yoon JW (2015) Ultrasound-based risk stratification for malignancy in thyroid nodules: a four-tier categorization system. Eur Radiol 25:2153–2162
Seo JW, Han K, Lee J, Kim EK, Moon HJ, Yoon JH, Park VY, Baek HM, Kwak JY (2018) Application of metabolomics in prediction of lymph node metastasis in papillary thyroid carcinoma. PLoS One 13:e0193883
Article PubMed PubMed Central Google Scholar
Siegel RL, Miller KD, Fuchs HE, Jemal A (2022) Cancer statistics, 2022. CA Cancer J Clin 72:7–33
Stonans I, Kuzmina J, Polaka I, Grinberga S, Sevostjanovs E, Liepins E, Aleksandravica I, Santare D, Kirsners A, Skapars R, Pcolkins A, Tolmanis I, Sivins A, Leja M, Dambrova M (2023) The association of circulating L-carnitine, gamma-butyrobetaine and trimethylamine N-oxide levels with gastric cancer. Diagnostics (basel) 13:1341
留言 (0)