Protein tyrosine phosphatase 1B in metabolic diseases and drug development

Klaman, L. D. et al. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol. Cell. Biol. 20, 5479–5489 (2000).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elchebly, M. et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283, 1544–1548 (1999).

Article  CAS  PubMed  Google Scholar 

Tonks, N. K., Diltz, C. D. & Fischer, E. H. Characterization of the major protein-tyrosine-phosphatases of human placenta. J. Biol. Chem. 263, 6731–6737 (1988).

Article  CAS  PubMed  Google Scholar 

Tonks, N. K., Diltz, C. D. & Fischer, E. H. Purification of the major protein-tyrosine-phosphatases of human placenta. J. Biol. Chem. 263, 6722–6730 (1988).

Article  CAS  PubMed  Google Scholar 

Tsou, R. C. & Bence, K. K. Central regulation of metabolism by protein tyrosine phosphatases. Front. Neurosci. 6, 192 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Tsou, R. C. & Bence, K. K. The genetics of PTPN1 and obesity: insights from mouse models of tissue-specific PTP1B deficiency. J. Obes. 2012, 926857 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Bence, K. K. et al. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat. Med. 12, 917–924 (2006).

Article  CAS  PubMed  Google Scholar 

Zabolotny, J. M. et al. PTP1B regulates leptin signal transduction in vivo. Dev. Cell. 2, 489–495 (2002).

Article  CAS  PubMed  Google Scholar 

De Jonghe, B. C. et al. Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. Am. J. Physiol. Endocrinol. Metab. 303, 644 (2012).

Article  Google Scholar 

Le Sommer, S. et al. Deficiency in protein tyrosine phosphatase PTP1B shortens lifespan and leads to development of acute leukemia. Cancer Res. 78, 75–87 (2018).

Article  PubMed  Google Scholar 

Dadke, S. et al. Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat. Cell Biol. 9, 80–85 (2007).

Article  CAS  PubMed  Google Scholar 

Fan, G., Lin, G., Lucito, R. & Tonks, N. K. Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells. J. Biol. Chem. 288, 24923–24934 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wiede, F. et al. T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice. J. Clin. Invest. 121, 4758–4774 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuchay, S. M., Kim, N., Grunz, E. A., Fay, W. P. & Chishti, A. H. Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets. Mol. Cell. Biol. 27, 6038–6052 (2007).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lanahan, A. A. et al. PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells. Circulation 130, 902–909 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martin-Granados, C. et al. A key role for PTP1B in dendritic cell maturation, migration, and T cell activation. J. Mol. Cell. Biol. 7, 517–528 (2015).

Article  CAS  PubMed  Google Scholar 

Thompson, D. et al. Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE-/- mouse model of atherosclerosis with alterations in IL10/AMPKα pathway. Mol. Metab. 6, 845–853 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simoncic, P. D., McGlade, C. J. & Tremblay, M. L. PTP1B and TC-PTP: novel roles in immune-cell signaling. Can. J. Physiol. Pharmacol. 84, 667–675 (2006).

Article  CAS  PubMed  Google Scholar 

Stuible, M. et al. Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives. Chembiochem 8, 179–186 (2007).

Article  CAS  PubMed  Google Scholar 

Gu, F. et al. Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling. Mol. Cell Biol. 23, 3753–3762 (2003).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heinonen, K. M., Bourdeau, A., Doody, K. M. & Tremblay, M. L. Protein tyrosine phosphatases PTP-1B and TC-PTP play nonredundant roles in macrophage development and IFN-γ signaling. Proc. Natl Acad. Sci. USA 106, 9368–9372 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bourdeau, A. et al. TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-γ. Blood 109, 4220–4228 (2007).

Article  CAS  PubMed  Google Scholar 

National Library of Medicine. PTPN1 protein tyrosine phosphatase non-receptor type 1 [Homo sapiens (human)]. NCBI https://www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Term=5770 (2024).

Barford, D., Flint, A. J. & Tonks, N. K. Crystal structure of human protein tyrosine phosphatase 1B. Science 263, 1397–1404 (1994).

Article  CAS  PubMed  Google Scholar 

Pannifer, A. D., Flint, A. J., Tonks, N. K. & Barford, D. Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography. J. Biol. Chem. 273, 10454–10462 (1998).

Article  CAS  PubMed  Google Scholar 

Haque, A., Andersen, J. N., Salmeen, A., Barford, D. & Tonks, N. K. Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity. Cell 147, 185–198 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salmeen, A., Andersen, J. N., Myers, M. P., Tonks, N. K. & Barford, D. Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol. Cell 6, 1401–1412 (2000).

Article  CAS  PubMed  Google Scholar 

Flint, A. J., Tiganis, T., Barford, D. & Tonks, N. K. Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases. Proc. Natl Acad. Sci. USA 94, 1680–1685 (1997).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomez, E. et al. Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B. J. Mol. Cell Cardiol. 52, 1257–1264 (2012).

Article  CAS  PubMed  Google Scholar 

Vercauteren, M. et al. Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure. Circulation 114, 2498–2507 (2006).

Article  CAS  PubMed  Google Scholar 

Coquerel, D. et al. Gene deletion of protein tyrosine phosphatase 1b protects against sepsis-induced cardiovascular dysfunction and mortality. Arterioscler. Thromb. Vasc. Biol. 34, 1032–1044 (2014).

Article  CAS  PubMed  Google Scholar 

Krishnan, N. et al. PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J. Clin. Invest. 125, 3163–3177 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Feldhammer, M., Uetani, N., Miranda-Saavedra, D. & Tremblay, M. L. PTP1B: a simple enzyme for a complex world. Crit. Rev. Biochem. Mol. Biol. 48, 430–445 (2013).

Article  CAS  PubMed  Google Scholar 

Vieira, M. N., Lyra, E., Silva, N. M., Ferreira, S. T. & De Felice, F. G. Protein tyrosine phosphatase 1B (PTP1B): a potential target for Alzheimer’s therapy? Front. Aging Neurosci. 9, 7 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Saha, S. & Chernoff, J. Analysis of PTP1B sumoylation. Methods 65, 201–206 (2014).

Article  CAS  PubMed  Google Scholar 

Meng, T., Buckley, D. A., Galic, S., Tiganis, T. & Tonks, N. K. Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B. J. Biol. Chem. 279, 37716–37725 (2004).

Article  CAS  PubMed  Google Scholar 

Schwertassek, U. et al. Reactivation of oxidized PTP1B and PTEN by thioredoxin 1. FEBS J. 281, 3545–3558 (2014).

Article  CAS 

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