Forestier E, Schmiegelow K. The incidence peaks of the childhood acute leukemias reflect specific cytogenetic aberrations. J Pediatr Hematol Oncol. 2006;28:486–95.
Article CAS PubMed Google Scholar
Iacobucci I, Mullighan CG. Genetic basis of acute lymphoblastic leukemia. J Clin Oncol. 2017;35:975–83.
Article CAS PubMed PubMed Central Google Scholar
Paulsson K, Johansson B. High hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2009;48:637–60.
Article CAS PubMed Google Scholar
Paulsson K, Lilljebjörn H, Biloglav A, Olsson L, Rissler M, Castor A, et al. The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia. Nat Genet. 2015;47:672–7.
Article CAS PubMed Google Scholar
Enshaei A, Vora A, Harrison CJ, Moppett J, Moorman AV. Defining low-risk high hyperdiploidy in patients with paediatric acute lymphoblastic leukaemia: a retrospective analysis of data from the UKALL97/99 and UKALL2003 clinical trials. Lancet Haematol. 2021;8:e828.
Article CAS PubMed PubMed Central Google Scholar
Ramos-Muntada M, Trincado JL, Blanco J, Bueno C, Rodríguez-Cortez VC, Bataller A, et al. Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high-hyperdiploid B-cell acute lymphoblastic leukemia. Mol Oncol. 2022;16:2899–919.
Article CAS PubMed PubMed Central Google Scholar
Betts DR, Riesch M, Grotzer MA, Niggli FK. The investigation of karyotypic instability in the high-hyperdiploidy subgroup of acute lymphoblastic leukemia. Leuk Lymphoma. 2001;42:187–93.
Article CAS PubMed Google Scholar
Talamo A, Chalandon Y, Marazzi A, Jotterand M. Clonal heterogeneity and chromosomal instability at disease presentation in high hyperdiploid acute lymphoblastic leukemia. Cancer Genet Cytogenet. 2010;203:209–14.
Article CAS PubMed Google Scholar
Yang M, Vesterlund M, Siavelis I, Moura-Castro LH, Castor A, Fioretos T, et al. Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia. Nat Commun. 2019;10. https://doi.org/10.1038/S41467-019-09469-3.
Molina O, Vinyoles M, Granada I, Roca-Ho H, Gutierrez-Agüera F, Valledor L, et al. Impaired condensin complex and Aurora B kinase underlie mitotic and chromosomal defects in hyperdiploid B-cell ALL. Blood. 2020;136:313–27.
PubMed PubMed Central Google Scholar
Moura-Castro LH, Peña-Martínez P, Castor A, Galeev R, Larsson J, Järås M, et al. Sister chromatid cohesion defects are associated with chromosomal copy number heterogeneity in high hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2021;60:410–7.
Article CAS PubMed PubMed Central Google Scholar
Onodera N, McCabe NR, Rubin CM. Formation of a hyperdiploid karyotype in childhood acute lymphoblastic leukemia. Blood. 1992;80:203–8.
Article CAS PubMed Google Scholar
Renate Panzer-Grümayer E, Fasching K, Panzer S, Hettinger K, Schmitt K, Stöckler-lpsiroglu S, et al. Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis. Blood. 2002;100:347–9.
Wiemels JL, Kang M, Chang JS, Zheng L, Kouyoumji C, Zhang L, et al. Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia. Blood Cells Mol Dis. 2010;45:186.
Article CAS PubMed PubMed Central Google Scholar
Bateman CM, Alpar D, Ford AM, Colman SM, Wren D, Morgan M, et al. Evolutionary trajectories of hyperdiploid ALL in monozygotic twins. Leukemia. 2014;29:58–65.
Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, et al. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet 2022 549. 2022;54:1376–89.
Davidow K, Mumanachit S, Mangum DS The two-hit hypothesis in practice: Monozygotic twins with simultaneous hyperdiploid acute lymphoblastic leukemia. Pediatr Blood Cancer. 2022. https://doi.org/10.1002/PBC.29885.
Ford AM, Colman S, Greaves M. Covert pre-leukaemic clones in healthy co-twins of patients with childhood acute lymphoblastic leukaemia. Leukemia. 2022. https://doi.org/10.1038/S41375-022-01756-1.
Davidsson J, Paulsson K, Lindgren D, Lilljebjörn H, Chaplin T, Forestier E, et al. Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations. Leukemia. 2010;24:924–31.
Article CAS PubMed Google Scholar
Lundin KB, Olsson L, Safavi S, Biloglav A, Paulsson K, Johansson B. Patterns and frequencies of acquired and constitutional uniparental isodisomies in pediatric and adult B-cell precursor acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2016;55:472–9.
Article CAS PubMed Google Scholar
Paulsson K, Horvat A, Strömbeck B, Nilsson F, Heldrup J, Behrendtz M, et al. Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosom Cancer. 2008;47:26–33.
Article CAS PubMed Google Scholar
Malinowska-Ozdowy K, Frech C, Schönegger A, Eckert C, Cazzaniga G, Stanulla M, et al. KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia. Leukemia. 2015;29:1656–67.
Article CAS PubMed PubMed Central Google Scholar
Waanders E, Gu Z, Dobson SM, Antić Ž, Crawford JC, Ma X, et al. Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia. Blood Cancer Discov. 2020;1:96–111.
Article CAS PubMed PubMed Central Google Scholar
Smith, de AJ, Ojha J, Francis SS, Sanders E, Endicott AA, et al. Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. Oncotarget. 2016;7:72733–45.
Article PubMed PubMed Central Google Scholar
Haas OA, Borkhardt A. Hyperdiploidy: the longest known, most prevalent, and most enigmatic form of acute lymphoblastic leukemia in children. Leukemia. 2022;2022:1–15.
Iwamoto T, Pu M, Ito M, Takahashi M, Isobe K‐I, Nagase F, et al. Preferential development of pre-B lymphomas with drastically down-regulated N-myc in the Eμ-ret transgenic mice. Eur J Immunol. 1991;21:1809–14.
Article CAS PubMed Google Scholar
Wasserman R, Zeng XX, Hardy RR. The evolution of B precursor leukemia in the Emu-ret mouse. Blood. 1998;92:273–82.
Article CAS PubMed Google Scholar
Zeng XX, Zhang H, Hardy RR, Wasserman R. The fetal origin of B-precursor leukemia in the E-mu-ret mouse. Blood. 1998;92:3529–36.
Article CAS PubMed Google Scholar
Frismantas V, Dobay MP, Rinaldi A, Tchinda J, Dunn SH, Kunz J, et al. Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia. Blood. 2017;129:e26–e37.
Article CAS PubMed PubMed Central Google Scholar
Guo M, Rever J, Nguyen PNU, Akella NM, Reid GSD, Maxwell CA. Centrosome amplification is a potential molecular target in paediatric acute lymphoblastic leukemia. 2022. https://doi.org/10.3390/cancers15010154.
R: The R Project for Statistical Computing. https://www.r-project.org/. Accessed 24 Dec 2022.
Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:1–21.
Yu G. Using meshes for MeSH term enrichment and semantic analyses. Bioinformatics. 2018;34:3766–7.
Article CAS PubMed Google Scholar
Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation. 2021;2. https://doi.org/10.1016/J.XINN.2021.100141.
Martin-Lorenzo A, Hauer J, Vicente-Duenas C, Auer F, Gonzalez-Herrero I, Garcia-Ramirez I, et al. Infection exposure is a causal factor in B-precursor acute lymphoblastic leukemia as a result of Pax5 inherited susceptibility. Cancer Discov. 2015;5:1328–43.
Hardy RR, Carmack CE, Shinton SA, Kemp JD, Hayakawa K. Resolution and characterization of Pro-B and Pre-Pro-B cell stages in normal mouse bone marrow. http://rupress.org/jem/article-pdf/173/5/1213/1394527/1213.pdf. Accessed 12 June 2023.
Seif AE, Barrett DM, Milone M, Brown VI, Grupp SA, Reid GSD Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood. 2009;114. https://doi.org/10.1182/blood-2009-02-203984.
Jo S, Lee JH, Mattei JJ, Barrett DM, Van Den Elzen P, Grupp SA, et al. Generation of a multi-antigen-directed immune response for durable control of acute lymphoblastic leukemia. Leukemia. 2018;32. https://doi.org/10.1038/leu.2017.290.
Senovilla L, Vitale I, Martins I, Tailler M, Pailleret C, Michaud M, et al. An immunosurveillance mechanism controls cancer cell ploidy. Science. 2012;337:1678–84.
Article CAS PubMed Google Scholar
McManus S, Ebert A, Salvagiotto G, Medvedovic J, Sun Q, Tamir I, et al. The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells. EMBO J. 2011;30:2388–404.
Article CAS PubMed PubMed Central Google Scholar
Miller JP, Izon D, DeMuth W, Gerstein R, Bhandoola A, Allman D. The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7. J Exp Med. 2002;196:705–11.
Article CAS PubMed PubMed Central Google Scholar
Maxwell CA, Keats JJ, Belch AR, Pilarski LM, Reiman T. Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity. Cancer Res. 2005;65:850–60.
Article CAS PubMed Google Scholar
Denu RA, Zasadil LM, Kanugh C, Laffin J, Weaver BA, Burkard ME. Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer. BMC Cancer. 2016;16:1–13.
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