Schwabe RF, Tabas I, Pajvani UB (2020) Mechanisms of fibrosis development in nonalcoholic steatohepatitis. Gastroenterology 158:1913–1928. https://doi.org/10.1053/j.gastro.2019.11.311
Article CAS PubMed Google Scholar
Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E (2018) Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol 15:11–20. https://doi.org/10.1038/nrgastro.2017.109
Dulai PS, Singh S, Patel J, Soni M, Prokop LJ, Younossi Z, Sebastiani G, Ekstedt M, Hagstrom H, Nasr P, Stal P, Wong VWS, Kechagias S, Hultcrantz R, Loomba R (2017) Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: systematic review and meta-analysis. Hepatology 65:1557–1565. https://doi.org/10.1002/hep.29085
Article CAS PubMed Google Scholar
Angulo P, Kleiner DE, Dam-Larsen S, Adams LA, Bjornsson ES, Charatcharoenwitthaya P, Mills PR, Keach JC, Lafferty HD, Stahler A, Haflidadottir S, Bendtsen F (2015) Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology 149:389-397.e10. https://doi.org/10.1053/j.gastro.2015.04.043
Vilar-Gomez E, Calzadilla-Bertot L, Wai-Sun Wong V, Castellanos M, Aller-de la Fuente R, Metwally M, Eslam M, Gonzalez-Fabian L, Sanz MAQ, Conde-Martin AF, De Boer B, McLeod D, Chan AWH, Chalasani N, George J, Adams LA, Romero-Gomez M (2018) Fibrosis severity as a determinant of cause-specific mortality in patients with advanced nonalcoholic fatty liver disease: a multi-national cohort study. Gastroenterology 155:443-457.e17. https://doi.org/10.1053/j.gastro.2018.04.034
Tilg H, Moschen AR (2010) Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 52:1836–1846. https://doi.org/10.1002/hep.24001
Article CAS PubMed Google Scholar
Hallsworth K, Adams LA (2019) Lifestyle modification in NAFLD/NASH: facts and figures. JHEP Rep 1:468–479. https://doi.org/10.1016/j.jhepr.2019.10.008
Article PubMed PubMed Central Google Scholar
Raza S, Rajak S, Upadhyay A, Tewari A, Anthony Sinha R (2021) Current treatment paradigms and emerging therapies for NAFLD/NASH. Front Biosci (Landmark Ed) 26:206–237. https://doi.org/10.2741/4892
Article CAS PubMed Google Scholar
Takahashi Y, Soejima Y, Kumagai A, Watanabe M, Uozaki H, Fukusato T (2014) Inhibitory effects of Japanese herbal medicines sho-saiko-to and juzen-taiho-to on nonalcoholic steatohepatitis in mice. PLoS ONE 9:e87279. https://doi.org/10.1371/journal.pone.0087279
Article ADS CAS PubMed PubMed Central Google Scholar
Takayama S, Michihara S, Kimura Y, Morinaga A, Miyakawa K, Tsushima N, Otani K, Jinnai A, Aso Y, Okabayashi A, Arita R, Nogami T, Inui A (2023) Review of frequently used Kampo prescriptions: part 4, Ninjin’yoeito. Trad Kampo Med 10:224–252. https://doi.org/10.1002/tkm2.1387
Kuniaki H, Akihiko T, Tetsuya H, Hatsuko M, Tomoko K, Shin O, Sojiro K, Mayumi Y, Fumihiro Y, Shintaro S, Tsukasa O, Hironori S (2018) Improvement in frailty in a patient with severe chronic obstructive pulmonary disease after Ninjin’yoeito therapy: a case report. Front Nutr 5:71. https://doi.org/10.3389/fnut.2018.00071
Article PubMed PubMed Central Google Scholar
Xu Y, Chen Y, Li P, Wang XS (2015) Ren Shen Yangrong Tang for fatigue in cancer survivors: a phase I/II open-label study. J Altern Complement Med 21:281–287. https://doi.org/10.1089/acm.2014.0211
Article PubMed PubMed Central Google Scholar
Ito T, Konishi A, Tsubokura Y, Azuma Y, Hotta M, Yoshimura H, Nakanishi T, Fujita S, Nakaya A, Satake A, Ishii K, Nomura S (2018) Combined use of Ninjin’yoeito improves subjective fatigue caused by lenalidomide in patients with multiple myeloma: a retrospective study. Front Nutr 5:72. https://doi.org/10.3389/fnut.2018.00072
Article CAS PubMed PubMed Central Google Scholar
Ohsawa M, Tanaka Y, Tanaka Y, Ehara Y, Makita S, Onaka K (2017) A possibility of simultaneous treatment with the multicomponent drug, Ninjin’yoeito, for anorexia, apathy, and cognitive dysfunction in frail Alzheimer’s disease patients: an open-label pilot study. J Alzheimers Dis Rep 1:229–235. https://doi.org/10.3233/ADR-170026
Article PubMed PubMed Central Google Scholar
Suzuki S, Aihara F, Shibahara M, Sakai K (2019) Safety and effectiveness of Ninjin’yoeito: a utilization study in elderly patients. Front Nutr 6:14. https://doi.org/10.3389/fnut.2019.00014
Article PubMed PubMed Central Google Scholar
Iwase S, Yamaguchi T, Miyaji T, Terawaki K, Inui A, Uezono Y (2012) The clinical use of Kampo medicines (traditional Japanese herbal treatments) for controlling cancer patients’ symptoms in Japan: a national cross-sectional survey. BMC Complement Altern Med 12:222. https://doi.org/10.1186/1472-6882-12-222
Article PubMed PubMed Central Google Scholar
Yoshikawa H, Ikeuchi T, Kai Y (1999) Clinical efficacy of Ninjin-Youei-To for recovery of reduced physical strength of the patients after prostate hypertrophy operation. Kampo Med (in Japanese) 49:617–622. https://doi.org/10.3937/KAMPOMED.49.617
Ando N (1999) Blood making effect of Ninjin-yoei-to (Ren-shen-yang-rong-tang) as monotherapy in obstetric and gynecologic patients with anemia. Kampo Med (in Japanese) 50:461–470. https://doi.org/10.3937/KAMPOMED.50.461
Motoo Y, Mouri H, Ohtsubo K, Yamaguchi Y, Watanabe H, Sawabu N (2005) Herbal medicine Ninjinyoeito ameliorates ribavirin-induced anemia in chronic hepatitis C: a randomized controlled trial. World J Gastroenterol 11:4013–4017. https://doi.org/10.3748/wjg.v11.i26.4013
Article PubMed PubMed Central Google Scholar
Ochi T, Kawakita T, Nomoto K (2004) Effects of Hochu-ekki-to and Ninjin-youei-to, traditional Japanese medicines, on porcine serum-induced liver fibrosis in rats. Immunopharmacol Immunotoxicol 26:285–298. https://doi.org/10.1081/iph-120037726
Swain MG (2006) Fatigue in liver disease: pathophysiology and clinical management. Can J Gastroenterol 20:181–188. https://doi.org/10.1155/2006/624832
Article PubMed PubMed Central Google Scholar
D’Mello C, Swain MG (2014) Liver-brain interactions in inflammatory liver diseases: implications for fatigue and mood disorders. Brain Behav Immun 35:9–20. https://doi.org/10.1016/j.bbi.2013.10.009
Article CAS PubMed Google Scholar
Swain MG, Jones DEJ (2019) Fatigue in chronic liver disease: new insights and therapeutic approaches. Liver Int 39:6–19. https://doi.org/10.1111/liv.13919
Newton JL, Jones DE, Henderson E, Kane L, Wilton K, Burt AD, Day CP (2008) Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance. Gut 57:807–813. https://doi.org/10.1136/gut.2007.139303
Article CAS PubMed Google Scholar
Younossi ZM, Wong VW, Anstee QM, Romero-Gomez M, Trauner MH, Harrison SA, Lawitz EJ, Okanoue T, Camargo M, Kersey K, Myers RP, Goodman Z, Stepanova M (2020) Fatigue and pruritus in patients with advanced fibrosis due to nonalcoholic steatohepatitis: the impact on patient-reported outcomes. Hepatol Commun 4:1637–1650. https://doi.org/10.1002/hep4.1581
Article CAS PubMed PubMed Central Google Scholar
Burak KW, Le T, Swain MG (2002) Increased sensitivity to the locomotor-activating effects of corticotropin-releasing hormone in cholestatic rats. Gastroenterology 122:681–688. https://doi.org/10.1053/gast.2002.31878
Article CAS PubMed Google Scholar
Contarino A, Dellu F, Koob GF, Smith GW, Lee KF, Vale WW, Gold LH (2000) Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice. Endocrinology 141:2698–2702. https://doi.org/10.1210/endo.141.7.7653
Article CAS PubMed Google Scholar
de Paiva VN, Lima SN, Fernandes MM, Soncini R, Andrade CA, Giusti-Paiva A (2010) Prostaglandins mediate depressive-like behaviour induced by endotoxin in mice. Behav Brain Res 215:146–151. https://doi.org/10.1016/j.bbr.2010.07.015
Article CAS PubMed Google Scholar
Murata K, Fujita N, Takahashi R, Inui A (2018) Ninjinyoeito improves behavioral abnormalities and hippocampal neurogenesis in the corticosterone model of depression. Front Pharmacol 9:1216. https://doi.org/10.3389/fphar.2018.01216
Article CAS PubMed PubMed Central Google Scholar
Nair AB, Jacob S (2016) A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 7:27–31. https://doi.org/10.4103/0976-0105.177703
Article PubMed PubMed Central Google Scholar
Matsumoto M, Hada N, Sakamaki Y, Uno A, Shiga T, Tanaka C, Ito T, Katsume A, Sudoh M (2013) An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis. Int J Exp Pathol 94:93–103. https://doi.org/10.1111/iep.12008
Article CAS PubMed PubMed Central Google Scholar
Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497–509. https://doi.org/10.1016/S0021-9258(18)64849-5
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