The protective effects of Ninjin’yoeito against liver steatosis/fibrosis in a non-alcoholic steatohepatitis model mouse

Schwabe RF, Tabas I, Pajvani UB (2020) Mechanisms of fibrosis development in nonalcoholic steatohepatitis. Gastroenterology 158:1913–1928. https://doi.org/10.1053/j.gastro.2019.11.311

Article  CAS  PubMed  Google Scholar 

Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E (2018) Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol 15:11–20. https://doi.org/10.1038/nrgastro.2017.109

Article  PubMed  Google Scholar 

Dulai PS, Singh S, Patel J, Soni M, Prokop LJ, Younossi Z, Sebastiani G, Ekstedt M, Hagstrom H, Nasr P, Stal P, Wong VWS, Kechagias S, Hultcrantz R, Loomba R (2017) Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: systematic review and meta-analysis. Hepatology 65:1557–1565. https://doi.org/10.1002/hep.29085

Article  CAS  PubMed  Google Scholar 

Angulo P, Kleiner DE, Dam-Larsen S, Adams LA, Bjornsson ES, Charatcharoenwitthaya P, Mills PR, Keach JC, Lafferty HD, Stahler A, Haflidadottir S, Bendtsen F (2015) Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology 149:389-397.e10. https://doi.org/10.1053/j.gastro.2015.04.043

Article  PubMed  Google Scholar 

Vilar-Gomez E, Calzadilla-Bertot L, Wai-Sun Wong V, Castellanos M, Aller-de la Fuente R, Metwally M, Eslam M, Gonzalez-Fabian L, Sanz MAQ, Conde-Martin AF, De Boer B, McLeod D, Chan AWH, Chalasani N, George J, Adams LA, Romero-Gomez M (2018) Fibrosis severity as a determinant of cause-specific mortality in patients with advanced nonalcoholic fatty liver disease: a multi-national cohort study. Gastroenterology 155:443-457.e17. https://doi.org/10.1053/j.gastro.2018.04.034

Article  PubMed  Google Scholar 

Tilg H, Moschen AR (2010) Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology 52:1836–1846. https://doi.org/10.1002/hep.24001

Article  CAS  PubMed  Google Scholar 

Hallsworth K, Adams LA (2019) Lifestyle modification in NAFLD/NASH: facts and figures. JHEP Rep 1:468–479. https://doi.org/10.1016/j.jhepr.2019.10.008

Article  PubMed  PubMed Central  Google Scholar 

Raza S, Rajak S, Upadhyay A, Tewari A, Anthony Sinha R (2021) Current treatment paradigms and emerging therapies for NAFLD/NASH. Front Biosci (Landmark Ed) 26:206–237. https://doi.org/10.2741/4892

Article  CAS  PubMed  Google Scholar 

Takahashi Y, Soejima Y, Kumagai A, Watanabe M, Uozaki H, Fukusato T (2014) Inhibitory effects of Japanese herbal medicines sho-saiko-to and juzen-taiho-to on nonalcoholic steatohepatitis in mice. PLoS ONE 9:e87279. https://doi.org/10.1371/journal.pone.0087279

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Takayama S, Michihara S, Kimura Y, Morinaga A, Miyakawa K, Tsushima N, Otani K, Jinnai A, Aso Y, Okabayashi A, Arita R, Nogami T, Inui A (2023) Review of frequently used Kampo prescriptions: part 4, Ninjin’yoeito. Trad Kampo Med 10:224–252. https://doi.org/10.1002/tkm2.1387

Article  Google Scholar 

Kuniaki H, Akihiko T, Tetsuya H, Hatsuko M, Tomoko K, Shin O, Sojiro K, Mayumi Y, Fumihiro Y, Shintaro S, Tsukasa O, Hironori S (2018) Improvement in frailty in a patient with severe chronic obstructive pulmonary disease after Ninjin’yoeito therapy: a case report. Front Nutr 5:71. https://doi.org/10.3389/fnut.2018.00071

Article  PubMed  PubMed Central  Google Scholar 

Xu Y, Chen Y, Li P, Wang XS (2015) Ren Shen Yangrong Tang for fatigue in cancer survivors: a phase I/II open-label study. J Altern Complement Med 21:281–287. https://doi.org/10.1089/acm.2014.0211

Article  PubMed  PubMed Central  Google Scholar 

Ito T, Konishi A, Tsubokura Y, Azuma Y, Hotta M, Yoshimura H, Nakanishi T, Fujita S, Nakaya A, Satake A, Ishii K, Nomura S (2018) Combined use of Ninjin’yoeito improves subjective fatigue caused by lenalidomide in patients with multiple myeloma: a retrospective study. Front Nutr 5:72. https://doi.org/10.3389/fnut.2018.00072

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ohsawa M, Tanaka Y, Tanaka Y, Ehara Y, Makita S, Onaka K (2017) A possibility of simultaneous treatment with the multicomponent drug, Ninjin’yoeito, for anorexia, apathy, and cognitive dysfunction in frail Alzheimer’s disease patients: an open-label pilot study. J Alzheimers Dis Rep 1:229–235. https://doi.org/10.3233/ADR-170026

Article  PubMed  PubMed Central  Google Scholar 

Suzuki S, Aihara F, Shibahara M, Sakai K (2019) Safety and effectiveness of Ninjin’yoeito: a utilization study in elderly patients. Front Nutr 6:14. https://doi.org/10.3389/fnut.2019.00014

Article  PubMed  PubMed Central  Google Scholar 

Iwase S, Yamaguchi T, Miyaji T, Terawaki K, Inui A, Uezono Y (2012) The clinical use of Kampo medicines (traditional Japanese herbal treatments) for controlling cancer patients’ symptoms in Japan: a national cross-sectional survey. BMC Complement Altern Med 12:222. https://doi.org/10.1186/1472-6882-12-222

Article  PubMed  PubMed Central  Google Scholar 

Yoshikawa H, Ikeuchi T, Kai Y (1999) Clinical efficacy of Ninjin-Youei-To for recovery of reduced physical strength of the patients after prostate hypertrophy operation. Kampo Med (in Japanese) 49:617–622. https://doi.org/10.3937/KAMPOMED.49.617

Article  Google Scholar 

Ando N (1999) Blood making effect of Ninjin-yoei-to (Ren-shen-yang-rong-tang) as monotherapy in obstetric and gynecologic patients with anemia. Kampo Med (in Japanese) 50:461–470. https://doi.org/10.3937/KAMPOMED.50.461

Article  Google Scholar 

Motoo Y, Mouri H, Ohtsubo K, Yamaguchi Y, Watanabe H, Sawabu N (2005) Herbal medicine Ninjinyoeito ameliorates ribavirin-induced anemia in chronic hepatitis C: a randomized controlled trial. World J Gastroenterol 11:4013–4017. https://doi.org/10.3748/wjg.v11.i26.4013

Article  PubMed  PubMed Central  Google Scholar 

Ochi T, Kawakita T, Nomoto K (2004) Effects of Hochu-ekki-to and Ninjin-youei-to, traditional Japanese medicines, on porcine serum-induced liver fibrosis in rats. Immunopharmacol Immunotoxicol 26:285–298. https://doi.org/10.1081/iph-120037726

Article  PubMed  Google Scholar 

Swain MG (2006) Fatigue in liver disease: pathophysiology and clinical management. Can J Gastroenterol 20:181–188. https://doi.org/10.1155/2006/624832

Article  PubMed  PubMed Central  Google Scholar 

D’Mello C, Swain MG (2014) Liver-brain interactions in inflammatory liver diseases: implications for fatigue and mood disorders. Brain Behav Immun 35:9–20. https://doi.org/10.1016/j.bbi.2013.10.009

Article  CAS  PubMed  Google Scholar 

Swain MG, Jones DEJ (2019) Fatigue in chronic liver disease: new insights and therapeutic approaches. Liver Int 39:6–19. https://doi.org/10.1111/liv.13919

Article  PubMed  Google Scholar 

Newton JL, Jones DE, Henderson E, Kane L, Wilton K, Burt AD, Day CP (2008) Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance. Gut 57:807–813. https://doi.org/10.1136/gut.2007.139303

Article  CAS  PubMed  Google Scholar 

Younossi ZM, Wong VW, Anstee QM, Romero-Gomez M, Trauner MH, Harrison SA, Lawitz EJ, Okanoue T, Camargo M, Kersey K, Myers RP, Goodman Z, Stepanova M (2020) Fatigue and pruritus in patients with advanced fibrosis due to nonalcoholic steatohepatitis: the impact on patient-reported outcomes. Hepatol Commun 4:1637–1650. https://doi.org/10.1002/hep4.1581

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burak KW, Le T, Swain MG (2002) Increased sensitivity to the locomotor-activating effects of corticotropin-releasing hormone in cholestatic rats. Gastroenterology 122:681–688. https://doi.org/10.1053/gast.2002.31878

Article  CAS  PubMed  Google Scholar 

Contarino A, Dellu F, Koob GF, Smith GW, Lee KF, Vale WW, Gold LH (2000) Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice. Endocrinology 141:2698–2702. https://doi.org/10.1210/endo.141.7.7653

Article  CAS  PubMed  Google Scholar 

de Paiva VN, Lima SN, Fernandes MM, Soncini R, Andrade CA, Giusti-Paiva A (2010) Prostaglandins mediate depressive-like behaviour induced by endotoxin in mice. Behav Brain Res 215:146–151. https://doi.org/10.1016/j.bbr.2010.07.015

Article  CAS  PubMed  Google Scholar 

Murata K, Fujita N, Takahashi R, Inui A (2018) Ninjinyoeito improves behavioral abnormalities and hippocampal neurogenesis in the corticosterone model of depression. Front Pharmacol 9:1216. https://doi.org/10.3389/fphar.2018.01216

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nair AB, Jacob S (2016) A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 7:27–31. https://doi.org/10.4103/0976-0105.177703

Article  PubMed  PubMed Central  Google Scholar 

Matsumoto M, Hada N, Sakamaki Y, Uno A, Shiga T, Tanaka C, Ito T, Katsume A, Sudoh M (2013) An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis. Int J Exp Pathol 94:93–103. https://doi.org/10.1111/iep.12008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497–509. https://doi.org/10.1016/S0021-9258(18)64849-5

Article  CAS  PubMed 

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