Peck, W. A., Birge, S. J. Jr. & Fedak, S. A. Bone cells: biochemical and biological studies after enzymatic isolation. Science 146, 1476–1477 (1964).
Article CAS PubMed Google Scholar
Otte, P. Basic cell metabolism of articular cartilage. Manometric studies. Z. Rheumatol. 50, 304–312 (1991).
Borle, A. B., Nichols, N. & Nichols, G. Jr. Metabolic studies of bone in vitro. I. Normal bone. J. Biol. Chem. 235, 1206–1210 (1960).
Article CAS PubMed Google Scholar
Stegen, S. & Carmeliet, G. The skeletal vascular system – breathing life into bone tissue. Bone 115, 50–58 (2018).
Article CAS PubMed Google Scholar
Long, F. Building strong bones: molecular regulation of the osteoblast lineage. Nat. Rev. Mol. Cell Biol. 13, 27–38 (2011).
Ikeda, K. & Takeshita, S. The role of osteoclast differentiation and function in skeletal homeostasis. J. Biochem. 159, 1–8 (2016).
Article CAS PubMed Google Scholar
Jacome-Galarza, C. E. et al. Developmental origin, functional maintenance and genetic rescue of osteoclasts. Nature 568, 541–545 (2019).
Article CAS PubMed PubMed Central Google Scholar
Kurenkova, A. D., Medvedeva, E. V., Newton, P. T. & Chagin, A. S. Niches for skeletal stem cells of mesenchymal origin. Front. Cell Dev. Biol. 8, 592 (2020).
Article PubMed PubMed Central Google Scholar
Roberts, S. J., van Gastel, N., Carmeliet, G. & Luyten, F. P. Uncovering the periosteum for skeletal regeneration: the stem cell that lies beneath. Bone 70, 10–18 (2015).
Ambrosi, T. H., Longaker, M. T. & Chan, C. K. F. A revised perspective of skeletal stem cell biology. Front. Cell Dev. Biol. 7, 189 (2019).
Article PubMed PubMed Central Google Scholar
Matsushita, Y., Ono, W. & Ono, N. Skeletal stem cells for bone development and repair: diversity matters. Curr. Osteoporos. Rep. 18, 189–198 (2020).
Article PubMed PubMed Central Google Scholar
Feng, H. et al. Skeletal stem cells: origins, definitions, and functions in bone development and disease. Life Med. 1, 276–293 (2022).
Article PubMed PubMed Central Google Scholar
Robling, A. G. & Bonewald, L. F. The osteocyte: new insights. Annu. Rev. Physiol. 82, 485–506 (2020).
Article CAS PubMed PubMed Central Google Scholar
Delgado-Calle, J. & Bellido, T. The osteocyte as a signaling cell. Physiol. Rev. 102, 379–410 (2022).
Article CAS PubMed Google Scholar
Dobnig, H. & Turner, R. T. Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells. Endocrinology 136, 3632–3638 (1995).
Article CAS PubMed Google Scholar
Long, F. & Ornitz, D. M. Development of the endochondral skeleton. Cold Spring Harb. Perspect. Biol. 5, a008334 (2013).
Article PubMed PubMed Central Google Scholar
Hallett, S. A., Ono, W. & Ono, N. The hypertrophic chondrocyte: to be or not to be. Histol. Histopathol. 36, 1021–1036 (2021).
CAS PubMed PubMed Central Google Scholar
Goldring, M. B. Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Ther. Adv. Musculoskelet. Dis. 4, 269–285 (2012).
Article CAS PubMed PubMed Central Google Scholar
Zhao, Z. et al. Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis. J. Cell Mol. Med. 24, 5408–5419 (2020).
Article CAS PubMed PubMed Central Google Scholar
Lee, P., Chandel, N. S. & Simon, M. C. Cellular adaptation to hypoxia through hypoxia inducible factors and beyond. Nat. Rev. Mol. Cell Biol. 21, 268–283 (2020).
Article CAS PubMed PubMed Central Google Scholar
Vander Heiden, M. G. & DeBerardinis, R. J. Understanding the Intersections between metabolism and cancer biology. Cell 168, 657–669 (2017).
Article PubMed Central Google Scholar
Martinez-Reyes, I. & Chandel, N. S. Cancer metabolism: looking forward. Nat. Rev. Cancer 21, 669–680 (2021).
Article CAS PubMed Google Scholar
Intlekofer, A. M. & Finley, L. W. S. Metabolic signatures of cancer cells and stem cells. Nat. Metab. 1, 177–188 (2019).
Article PubMed PubMed Central Google Scholar
Couasnay, G., Madel, M. B., Lim, J., Lee, B. & Elefteriou, F. Sites of Cre-recombinase activity in mouse lines targeting skeletal cells. J. Bone Miner. Res. 36, 1661–1679 (2021).
Article CAS PubMed Google Scholar
Tournaire, G. et al. Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle. Cell Rep. 40, 111105 (2022).
Article CAS PubMed PubMed Central Google Scholar
Stegen, S. & Carmeliet, G. Hypoxia, hypoxia-inducible transcription factors and oxygen-sensing prolyl hydroxylases in bone development and homeostasis. Curr. Opin. Nephrol. Hypertens. 28, 328–335 (2019).
Article CAS PubMed Google Scholar
Lee, S. Y., Abel, E. D. & Long, F. Glucose metabolism induced by Bmp signaling is essential for murine skeletal development. Nat. Commun. 9, 4831 (2018).
Article PubMed PubMed Central Google Scholar
Jeoung, N. H. Pyruvate dehydrogenase kinases: therapeutic targets for diabetes and cancers. Diabetes Metab. J. 39, 188–197 (2015).
Article PubMed PubMed Central Google Scholar
Heinemann-Yerushalmi, L. et al. BCKDK regulates the TCA cycle through PDC in the absence of PDK family during embryonic development. Dev. Cell 56, 1182–1194.e6 (2021).
Article CAS PubMed Google Scholar
van Gastel, N. et al. Lipid availability determines fate of skeletal progenitor cells via SOX9. Nature 579, 111–117 (2020).
Article PubMed PubMed Central Google Scholar
Hu, G. et al. The amino acid sensor Eif2ak4/GCN2 is required for proliferation of osteoblast progenitors in mice. J. Bone Miner. Res. 35, 2004–2014 (2020).
Devignes, C. S., Carmeliet, G. & Stegen, S. Amino acid metabolism in skeletal cells. Bone Rep. 17, 101620 (2022).
Article CAS PubMed PubMed Central Google Scholar
Stegen, S. et al. HIF-1ɑ promotes glutamine-mediated redox homeostasis and glycogen-dependent bioenergetics to support postimplantation bone cell survival. Cell Metab. 23, 265–279 (2016).
Article CAS PubMed PubMed Central Google Scholar
Stegen, S. et al. Glutamine metabolism controls chondrocyte identity and function. Dev. Cell 53, 530–544.e8 (2020).
Article CAS PubMed Google Scholar
Yu, Y. et al. Glutamine metabolism regulates proliferation and lineage allocation in skeletal stem cells. Cell Metab. 29, 966–978.e4 (2019).
Article CAS PubMed PubMed Central Google Scholar
Solidum, J. G. N., Jeong, Y., Heralde, F. 3rd & Park, D. Differential regulation of skeletal stem/progenitor cells in distinct skeletal compartments. Front. Physiol. 14, 1137063 (2023).
Article PubMed PubMed Central Google Scholar
Spencer, J. A. et al. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature 508, 269–273 (2014).
Article CAS PubMed PubMed Central Google Scholar
Loopmans, S., Stockmans, I., Carmeliet, G. & Stegen, S. Isolation and in vitro characterization of murine young-adult long bone skeletal progenitors. Front. Endocrinol. 13, 930358 (2022).
留言 (0)