From the Department of Anesthesiology, Duke University, Durham, North Carolina.

Accepted for publication September 21, 2023.

Reprints will not be available from the authors.

Funding: This work was supported by the National Institutes of Health (R01 DA042985 to E.D.K.).

The authors declare no conflicts of interest.

Clinical Trial Registration: ClinicalTrials.gov NCT03726268 (https://clinicaltrials.gov/ct2/show/NCT03726268).

Data will be shared upon reasonable request.

Address correspondence to Evan Kharasch, MD, PhD, Department of Anesthesiology, Duke University, 905 S. Lasalle St GSRB Rm 2031, Durham, NC 27710. Address e-mail to [email protected].