AbbreviationsGDM
gestational diabetes mellitus
APA
alternative polyadenylation
3'UTRs
3' untranslated regions
qRT-PCR
quantitative real-time polymerase chain reaction
TDMs
THP-1 derived macrophages
HUVECs
human umbilical vein endothelial cells
ADSCs
adipose-derived stem cells
NSC
subcutaneous adipose tissue from control cases
GSC
subcutaneous adipose tissue from GDM patients
NOM
omental adipose tissue from control cases
GOM
omental adipose tissue from GDM patients
snRNA-seqSingle-nucleus
RNA sequencing
PDUI
percentage of distal polyA site usage index
PMA
phorbol 12-Myristate 13-Acetate
PCA
principal component analysis
DEmRNA
differentially expressed mRNA
DEP
differentially expressed protein
DEG
differentially expressed gene
CPSF
cleavage and polyadenylation specificity factor
CSTF
cleavage stimulation factor
Keywords
Gestational diabetes mellitus
alternative polyadenylation
adipose tissue
transcriptomics
proteomics
metabolic disorders
inflammation
Availability of data and materials
Most of the data generated or analysed during this study are included in this published article and its supplementary information files. The sequencing raw data used and analysed during the current study are available from the corresponding author on reasonable request.
© 2024 Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
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