Trastuzumab: dreams, desperation and hope

Sugarman, B. J. et al. Recombinant human tumor necrosis factor-α: effects on proliferation of normal and transformed cells in vitro. Science 230, 943–945 (1985).

Article  CAS  PubMed  Google Scholar 

Urban, J. L., Shepard, H. M., Rothstein, J. L., Sugarman, B. J. & Schreiber, H. Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages. PNAS 83, 5233–5237 (1986).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lewis, G. D., Aggarwal, B. B., Eessalu, T. E., Sugarman, B. J. & Shepard, H. M. Modulation of the growth of transformed cells by human tumor necrosis factor-α and interferon-γ. Cancer Res. 47, 5382–5385 (1987).

CAS  PubMed  Google Scholar 

Sugarman, B. J., Lewis, G. D., Eessalu, T. E., Aggarwal, B. B. & Shepard, H. M. Effects of growth factors on the antiproliferative activity of tumor necrosis factors. Cancer Res. 47, 780–786 (1987).

CAS  PubMed  Google Scholar 

Coussens, L. et al. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 230, 1132–1139 (1985).

Article  CAS  PubMed  Google Scholar 

Slamon, D. J. et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235, 177–182 (1987).

Article  CAS  PubMed  Google Scholar 

Hudziak, R. M. et al. p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. Mol. Cell. Biol. 9, 1165–1172 (1989).

CAS  PubMed  PubMed Central  Google Scholar 

Fendly, B. M. Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product. Cancer Res. 50, 1550–1558 (1990).

CAS  PubMed  Google Scholar 

Pegram, M. et al. Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers. Oncogene 18, 2241–2251 (1999).

Article  CAS  PubMed  Google Scholar 

Stohrer, M., Boucher, Y., Stangassinger, M. & Jain, R. K. Oncotic pressure in solid tumors is elevated. Cancer Res. 60, 4251–4255 (2000).

CAS  PubMed  Google Scholar 

Carter, P. et al. Humanization of an anti-p185HER2 antibody for human cancer therapy. PNAS 89, 4285–4289 (1992).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baselga, J. Herceptin® alone or in combination with chemotherapy in the treatment of HER2-positive metastatic breast cancer: pivotal trials. Oncology 61, 14–21 (2001).

Article  CAS  PubMed  Google Scholar 

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