A Comprehensive Study of Heterogeneous Mismatch Repair Expression in Solid Tumors Reveals Different Immunohistochemical Patterns and Distinct Genetic Mechanisms

Department of Pathology, State Key Laboratory of Complex Severe and Rare Diseases, Molecular Pathology Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

The datasets used, generated, and analyzed during the present study are available from the corresponding authors upon reasonable request

J.W., Z.Z. and Y.C. contributed equally.

This research is supported by CAMS Innovation Fund for Medical Sciences (CIFMS) 2021-I2M-1-002, National High-Level Hospital Clinical Research Funding (2022-PUMCH-B-063), Fundamental Research Funds for the Central Universities (3332023006) and National Natural Science Foundation of China (82072747 and 82072749).

Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

Correspondence: Zhiyong Liang, MD, PhD (e-mail: [email protected]), and Huanwen Wu, MD, PhD (e-mail: [email protected]), Department of Pathology, State Key Laboratory of Complex Severe and Rare Diseases, Molecular Pathology Research Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.

Supplemental Digital Content is available for this article. Direct URL citations are provided in the HTML and PDF versions of this article on the journal’s website, www.ajsp.com.

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