Armstrong DK, Bundy B, Wenzel L, Huang HQ, Baergen R, Lele S, Copeland LJ, Walker JL, Burger RA (2006) Gynecologic oncology, intraperitoneal cisplatin and paclitaxel in ovarian cancer. N Engl J Med 354:34–43
Article CAS PubMed Google Scholar
Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, McKeon F, Lynch M, Crum CP, Hegde P, Brewer M, Wang X, Miller LD, Dyment N, Torti FM (2017) Torti, Iron addiction: a novel therapeutic target in ovarian cancer. Oncogene 36:4089–4099
Article CAS PubMed PubMed Central Google Scholar
Ben-Sahra I, Hoxhaj G, Ricoult SJH, Asara JM (2016) Manning, mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science 351:728–733
Article ADS CAS PubMed PubMed Central Google Scholar
Cookson BT, Brennan MA (2001) Pro-inflammatory programmed cell death. Trends Microbiol 9:113–114
Article CAS PubMed Google Scholar
Cui X, Su H, Yang J, Wu X, Huo K, Jing X, Zhang S (2022) Up-regulation of MTHFD2 is associated with clinicopathological characteristics and poor survival in ovarian cancer, possibly by regulating MOB1A signaling. J Ovarian Res 15:23
Article CAS PubMed PubMed Central Google Scholar
Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 1:112–119
Article CAS PubMed Google Scholar
Deng X, Liu X, Hu B, Liu J, Fu B, Zhang W (2023) Upregulation of MTHFD2 is associated with PD–L1 activation in bladder cancer via the PI3K/AKT pathway. Int J Mol Med 51.
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060–1072
Article CAS PubMed PubMed Central Google Scholar
Ganapathy-Kanniappan S, Geschwind JF (2013) Tumor glycolysis as a target for cancer therapy: progress and prospects. Mol Cancer 12:152
Article PubMed PubMed Central Google Scholar
Hurwitz LM, Pinsky PF, Trabert B (2021) General population screening for ovarian cancer. Lancet 397:2128–2130
Jin Y, Chen L, Li L, Huang G, Huang H, Tang C (2022) SNAI2 promotes the development of ovarian cancer through regulating ferroptosis. Bioengineered 13:6451–6463
Article CAS PubMed PubMed Central Google Scholar
Khamseekaew J, Kumfu S, Wongjaikam S, Kerdphoo S, Jaiwongkam T, Srichairatanakool S, Fucharoen S, Chattipakorn SC, Chattipakorn N (2017) Effects of iron overload, an iron chelator and a T-Type calcium channel blocker on cardiac mitochondrial biogenesis and mitochondrial dynamics in thalassemic mice. Eur J Pharmacol 799:118–127
Article CAS PubMed Google Scholar
Koppula P, Zhuang L, Gan B (2021) Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell 12:599–620
Article CAS PubMed Google Scholar
Koufaris C, Gallage S, Yang T, Lau CH, Valbuena GN, Keun HC (2016) Suppression of MTHFD2 in MCF-7 breast Cancer cells increases glycolysis, dependency on exogenous Glycine, and sensitivity to Folate Depletion. J Proteome Res 15:2618–2625
Article CAS PubMed Google Scholar
Kumfu S, Chattipakorn S, Fucharoen S, Chattipakorn N (2012) Mitochondrial calcium uniporter blocker prevents cardiac mitochondrial dysfunction induced by iron overload in thalassemic mice. Biometals 25:1167–1175
Article CAS PubMed Google Scholar
Li Q, Yang F, Shi X, Bian S, Shen F, Wu Y, Zhu C, Fu F, Wang J, Zhou J, Chen Y (2021) MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway. FEBS Open Bio 11:2845–2857
Article CAS PubMed PubMed Central Google Scholar
Liu Y, Liu X, Wang H, Ding P, Wang C (2022a) Agrimonolide inhibits cancer progression and induces ferroptosis and apoptosis by targeting SCD1 in ovarian cancer cells. Phytomedicine 101:154102
Article CAS PubMed Google Scholar
Liu Z, Xu Y, Liu X, Wang B (2022b) PCDH7 knockdown potentiates colon cancer cells to chemotherapy via inducing ferroptosis and changes in autophagy through restraining MEK1/2/ERK/c-Fos axis. Biochem Cell Biol 100:445–457
Article CAS PubMed Google Scholar
Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B (2021) DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature 593:586–590
Article ADS CAS PubMed PubMed Central Google Scholar
Matz M, Coleman MP, Carreira H, Salmeron D, Chirlaque MD, Allemani C, Group CW (2017) Worldwide comparison of ovarian cancer survival: histological group and stage at diagnosis (CONCORD-2). Gynecol Oncol 144:396–404
Moore K, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Banerjee S, Oza A, Gonzalez-Martin A, Aghajanian C, Bradley W, Mathews C, Liu J, Lowe ES, Bloomfield R, DiSilvestro P (2018) Maintenance Olaparib in patients with newly diagnosed Advanced Ovarian Cancer. N Engl J Med 379:2495–2505
Article CAS PubMed Google Scholar
Morscher RJ, Ducker GS, Li SH, Mayer JA, Gitai Z, Sperl W, Rabinowitz JD (2018) Mitochondrial translation requires folate-dependent tRNA methylation. Nature 554:128–132
Article ADS CAS PubMed PubMed Central Google Scholar
Nilsson R, Jain M, Madhusudhan N, Sheppard NG, Strittmatter L, Kampf C, Huang J, Asplund A, Mootha VK (2014) Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nat Commun 5:3128
Article ADS PubMed Google Scholar
Perren TJ, Swart AM, Pfisterer J, Ledermann JA, Pujade-Lauraine E, Kristensen G, Carey MS, Beale P, Cervantes A, Kurzeder C, du Bois A, Sehouli J, Kimmig R, Stahle A, Collinson F, Essapen S, Gourley C, Lortholary A, Selle F, Mirza MR, Leminen A, Plante M, Stark D, Qian W, Parmar MK, Oza AM, Investigators I (2011) A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med 365:2484–2496
Article CAS PubMed Google Scholar
Schweichel JU, Merker HJ (1973) The morphology of various types of cell death in prenatal tissues. Teratology 7:253–266
Article CAS PubMed Google Scholar
Siegel RL, Miller KD, Fuchs HE, Jemal A (2021) Cancer Stat 2021 CA Cancer J Clin 71:7–33
Song Q, Peng S, Che F, Zhu X (2022) Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells. J Pharmacol Sci 148:300–306
Article CAS PubMed Google Scholar
Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascon S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD (2017) Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell 171: 273–285
Tan Z, Huang H, Sun W, Li Y, Jia Y (2022) Current progress of ferroptosis study in ovarian cancer. Front Mol Biosci 9:966007
Article CAS PubMed PubMed Central Google Scholar
Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, Gaudet MM, Jemal A, Siegel RL (2018) Ovarian cancer statistics, 2018. CA Cancer J Clin 68:284–296
Article PubMed PubMed Central Google Scholar
Wan X, Wang C, Huang Z, Zhou D, Xiang S, Qi Q, Chen X, Arbely E, Liu CY, Du P, Yu W (2020) Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell. Cell Death Dis 11:649
Article CAS PubMed PubMed Central Google Scholar
Wang W, Green M, Choi JE, Gijon M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, Xia H, Zhou J, Li G, Li J, Li W, Wei S, Vatan L, Zhang H, Szeliga W, Gu W, Liu R, Lawrence TS, Lamb C, Tanno Y, Cieslik M, Stone E, Georgiou G, Chan TA, Chinnaiyan A, Zou W (2019) CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy. Nature 569:270–274
Article ADS CAS PubMed PubMed Central Google Scholar
Wu S, Cai W, Shi Z, Ming X, Yang X, Zhou Y, Chen X, Yang M (2022) Knockdown of MTHFD2 inhibits proliferation and migration of nasopharyngeal carcinoma cells through the ERK signaling pathway. Biochem Biophys Res Commun 614:47–55
Article CAS PubMed Google Scholar
Yue L, Pei Y, Zhong L, Yang H, Wang Y, Zhang W, Chen N, Zhu Q, Gao J, Zhi M, Wen B, Zhang S, Xiang J, Wei Q, Liang H, Cao S, Lou H, Chen Z, Han J (2020) Mthfd2 modulates mitochondrial function and DNA repair to maintain the pluripotency of mouse stem cells. Stem Cell Rep 15:529–545
Zhang C, Liu X, Jin S, Chen Y, Guo R (2022) Ferroptosis in cancer therapy: a novel approach to reversing drug resistance. Mol Cancer 21:47
留言 (0)