Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;289:3095–105.
Lépine JP, Briley M. The increasing burden of depression. Neuropsychiatr Dis Treat. 2011;7:3–7.
PubMed PubMed Central Google Scholar
Kaufman J, Charney D. Comorbidity of mood and anxiety disorders. Depress Anxiety. 2000;12:69–76.
Berton O, Nestler EJ. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci. 2006;7:137–51.
Article CAS PubMed Google Scholar
Lin S, Huang L, Luo ZC, Li X, Jin SY, Du ZJ, et al. The ATP level in the medial prefrontal cortex regulates depressive-like behavior via the medial prefrontal cortex-lateral habenula pathway. Biol Psychiatry. 2022;92:179–92.
Article CAS PubMed Google Scholar
Hare BD, Duman RS. Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions. Mol Psychiatry. 2020;25:2742–58.
Article PubMed PubMed Central Google Scholar
Anastasiades PG, Carter AG. Circuit organization of the rodent medial prefrontal cortex. Trends Neurosci. 2021;44:550–63.
Article CAS PubMed PubMed Central Google Scholar
Bittar TP, Labonte B. Functional contribution of the medial prefrontal circuitry in major depressive disorder and stress-induced depressive-like behaviors. Front Behav Neurosci. 2021;15:699592.
Article PubMed PubMed Central Google Scholar
Chen Y, Hu N, Yang J, Gao T. Prefrontal cortical circuits in anxiety and fear: an overview. Front Med. 2022;16:518–39.
Hu H, Cui Y, Yang Y. Circuits and functions of the lateral habenula in health and in disease. Nat Rev Neurosci. 2020;21:277–95.
Article CAS PubMed Google Scholar
Ables JL, Park K, Ibanez-Tallon I. Understanding the habenula: a major node in circuits regulating emotion and motivation. Pharmacol Res. 2023;190:106734.
Huang L, Chen X, Tao Q, Wang X, Huang X, Fu Y, et al. Bright light treatment counteracts stress-induced sleep alterations in mice, via a visual circuit related to the rostromedial tegmental nucleus. PLoS Biol. 2023;21:e3002282.
Article CAS PubMed PubMed Central Google Scholar
Huang L, Xi Y, Peng Y, Yang Y, Huang X, Fu Y, et al. A visual circuit related to habenula underlies the antidepressive effects of light therapy. Neuron. 2019;102:128–42.e8.
Article CAS PubMed Google Scholar
Vertes RP. Differential projections of the infralimbic and prelimbic cortex in the rat. Synapse. 2004;51:32–58.
Article CAS PubMed Google Scholar
Hoover WB, Vertes RP. Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat. Brain Struct Funct. 2007;212:149–79.
Heidbreder CA, Groenewegen HJ. The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics. Neurosci Biobehav Rev. 2003;27:555–79.
Yashima J, Uekita T, Sakamoto T. The prelimbic cortex but not the anterior cingulate cortex plays an important role in social recognition and social investigation in mice. PLoS ONE. 2023;18:e0284666.
Article CAS PubMed PubMed Central Google Scholar
de Kloet SF, Bruinsma B, Terra H, Heistek TS, Passchier EMJ, van den Berg AR, et al. Bi-directional regulation of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatum. Nat Commun. 2021;12:1994.
Article PubMed PubMed Central Google Scholar
Wang M, Gallo NB, Tai Y, Li B, Van Aelst L. Oligophrenin-1 moderates behavioral responses to stress by regulating parvalbumin interneuron activity in the medial prefrontal cortex. Neuron. 2021;109:1636–56.e8.
Article CAS PubMed PubMed Central Google Scholar
Bi LL, Wang J, Luo ZY, Chen SP, Geng F, Chen YH, et al. Enhanced excitability in the infralimbic cortex produces anxiety-like behaviors. Neuropharmacology. 2013;72:148–56.
Article CAS PubMed Google Scholar
Perova Z, Delevich K, Li B. Depression of excitatory synapses onto parvalbumin interneurons in the medial prefrontal cortex in susceptibility to stress. J Neurosci. 2015;35:3201–6.
Article CAS PubMed PubMed Central Google Scholar
Covington HE 3rd, Lobo MK, Maze I, Vialou V, Hyman JM, Zaman S, et al. Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci. 2010;30:16082–90.
Article CAS PubMed PubMed Central Google Scholar
Lee EH, Park JY, Kwon HJ, Han PL. Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice. Nat Commun. 2021;12:6682.
Article ADS CAS PubMed PubMed Central Google Scholar
Huang WC, Zucca A, Levy J, Page DT. Social behavior is modulated by valence-encoding mPFC-amygdala sub-circuitry. Cell Rep. 2020;32:107899.
Article CAS PubMed PubMed Central Google Scholar
Liu WZ, Zhang WH, Zheng ZH, Zou JX, Liu XX, Huang SH, et al. Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety. Nat Commun. 2020;11:2221.
Article ADS CAS PubMed PubMed Central Google Scholar
Cui Y, Huang X, Huang P, Huang L, Feng Z, Xiang X, et al. Reward ameliorates depressive-like behaviors via inhibition of the substantia innominata to the lateral habenula projection. Sci Adv. 2022;8:eabn0193.
Article CAS PubMed PubMed Central Google Scholar
Warden MR, Selimbeyoglu A, Mirzabekov JJ, Lo M, Thompson KR, Kim SY, et al. A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature. 2012;492:428–32.
Article ADS CAS PubMed PubMed Central Google Scholar
Benekareddy M, Stachniak TJ, Bruns A, Knoflach F, von Kienlin M, Künnecke B, et al. Identification of a corticohabenular circuit regulating socially directed behavior. Biol Psychiatry. 2018;83:607–17.
Mathis VP, Williams M, Fillinger C, Kenny PJ. Networks of habenula-projecting cortical neurons regulate cocaine seeking. Sci Adv. 2021;7:eabj2225.
Article ADS CAS PubMed PubMed Central Google Scholar
Cao P, Chen C, Liu A, Shan Q, Zhu X, Jia C, et al. Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines. Neuron. 2021;109:2573–89.e9.
Article CAS PubMed Google Scholar
Chana G, Landau S, Beasley C, Everall IP, Cotter D. Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density. Biol Psychiatry. 2003;53:1086–98.
Yang Y, Cui Y, Sang K, Dong Y, Ni Z, Ma S, et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression. Nature. 2018;554:317–22.
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