Schroder, K. & Tschopp, J. The inflammasomes. Cell 140, 821–832 (2010).
Article CAS PubMed Google Scholar
Martinon, F., Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell. 10, 417–426 (2002).
Article CAS PubMed Google Scholar
Takeuchi, O. & Akira, S. Pattern recognition receptors and inflammation. Cell 140, 805–820 (2010).
Article CAS PubMed Google Scholar
Swanson, K. V., Deng, M. & Ting, J. P.-Y. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat. Rev. Immunol. 19, 477–489 (2019).
Article CAS PubMed PubMed Central Google Scholar
He, Y., Zeng, M. Y., Yang, D., Motro, B. & Nunez, G. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530, 354–357 (2016).
Article ADS CAS PubMed PubMed Central Google Scholar
Chung, I.-C. et al. Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis. Sci. Rep. 6, 36214 (2016).
Article ADS CAS PubMed PubMed Central Google Scholar
Guo, H., Callaway, J. B. & Ting, J. P.-Y. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat. Med. 21, 677–687 (2015).
Article PubMed PubMed Central Google Scholar
Wen, H., Ting, J. P.-Y. & O’Neill, L. A. A role for the NLRP3 inflammasome in metabolic diseases–did Warburg miss inflammation? Nat. Immunol. 13, 352–357 (2012).
Article CAS PubMed PubMed Central Google Scholar
Freeman, L. C. & Ting, J. P.-Y The pathogenic role of the inflammasome in neurodegenerative diseases. J. Neurochem. 136, 29–38 (2016).
Article CAS PubMed Google Scholar
Prochnicki, T. & Latz, E. Inflammasomes on the crossroads of innate immune recognition and metabolic control. Cell Metab. 26, 71–93 (2017).
Article CAS PubMed Google Scholar
Hughes, M. M. & O’Neill, L. A. J. Metabolic regulation of NLRP3. Immunol. Rev. 281, 88–98 (2018).
Article CAS PubMed Google Scholar
Akira, S., Misawa, T., Satoh, T. & Saitoh, T. Macrophages control innate inflammation. Diabetes Obes. Metab. 15, 10–18 (2013).
Article CAS PubMed Google Scholar
Abraham, S. N. & St John, A. L. Mast cell-orchestrated immunity to pathogens. Nat. Rev. Immunol. 10, 440–452 (2010).
Article CAS PubMed PubMed Central Google Scholar
Gilfillan, A. M. & Tkaczyk, C. Integrated signalling pathways for mast-cell activation. Nat. Rev. Immunol. 6, 218–230 (2006).
Article CAS PubMed Google Scholar
Nakamura, Y. et al. Critical role for mast cells in interleukin-1beta-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Immunity 37, 85–95 (2012).
Article CAS PubMed PubMed Central Google Scholar
Jin, C. et al. Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation. J. Clin. Invest. 127, 3913 (2017).
Article PubMed PubMed Central Google Scholar
Hogan, P. G., Lewis, R. S. & Rao, A. Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu. Rev. Immunol. 28, 491–533 (2010).
Article CAS PubMed PubMed Central Google Scholar
Lorentz, A., Baumann, A., Vitte, J. & Blank, U. The SNARE machinery in mast cell secretion. Front. Immunol. 3, 143 (2012).
Article PubMed PubMed Central Google Scholar
Dwyer, D. F., Barrett, N. A., Austen, K. F. & Immunological Genome Project Consortium Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nat. Immunol. 17, 878–887 (2016).
Article CAS PubMed PubMed Central Google Scholar
Nocka, K. et al. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J. 9, 1805–1813 (1990).
Article CAS PubMed PubMed Central Google Scholar
Falcone, F. H., Wan, D., Barwary, N. & Sagi-Eisenberg, R. RBL cells as models for in vitro studies of mast cells and basophils. Immunol. Rev. 282, 47–57 (2018).
Article CAS PubMed Google Scholar
Galli, S. J. & Tsai, M. IgE and mast cells in allergic disease. Nat. Med. 18, 693–704 (2012).
Article CAS PubMed PubMed Central Google Scholar
Huber, M., Hughes, M. R. & Krystal, G. Thapsigargin-induced degranulation of mast cells is dependent on transient activation of phosphatidylinositol-3 kinase. J. Immunol. 165, 124–133 (2000).
Article CAS PubMed Google Scholar
Stehlik, C. et al. Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation. J. Immunol. 171, 6154–6163 (2003).
Article CAS PubMed Google Scholar
Byrne, M. J. et al. Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine. Biochem. J. 477, 1525–1539 (2020).
Article CAS PubMed Google Scholar
He, H. et al. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat. Commun. 9, 2550 (2018).
Article ADS PubMed PubMed Central Google Scholar
Hara, H. et al. Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity. Nat. Immunol. 14, 1247–1255 (2013).
Article CAS PubMed PubMed Central Google Scholar
Okazaki, H., Zhang, J., Hamawy, M. M. & Siraganian, R. P. Activation of protein-tyrosine kinase Pyk2 is downstream of Syk in FcεRI signaling. J. Biol. Chem. 272, 32443–32447 (1997).
Article CAS PubMed Google Scholar
Cheung, S. M. & Ostergaard, H. L. Pyk2 controls integrin-dependent CTL migration through regulation of de-adhesion. J. Immunol. 197, 1945–1956 (2016).
Article CAS PubMed Google Scholar
Nishida, K. et al. FcεRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J. Cell Biol. 170, 115–126 (2005).
Article CAS PubMed PubMed Central Google Scholar
Draber, P., Sulimenko, V. & Draberova, E. Cytoskeleton in mast cell signaling. Front. Immunol. 3, 130 (2012).
Article PubMed PubMed Central Google Scholar
Liu, Y., Zhu, M., Nishida, K., Hirano, T. & Zhang, W. An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J. Exp. Med. 204, 93–103 (2007).
Article CAS PubMed PubMed Central Google Scholar
Reck-Peterson, S. L., Redwine, W. B., Vale, R. D. & Carter, A. P. The cytoplasmic dynein transport machinery and its many cargoes. Nat. Rev. Mol. Cell Biol. 19, 382–398 (2018).
Article CAS PubMed PubMed Central Google Scholar
Jiang, H. et al. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J. Exp. Med. 214, 3219–3238 (2017).
Article CAS PubMed PubMed Central Google Scholar
Suurmond, J., Habets, K. L. L., Dorjee, A. L., Huizinga, T. W. & Toes, R. E. M. Expansion of Th17 cells by human mast cells is driven by inflammasome-independent IL-1beta. J. Immunol. 197, 4473–4481 (2016).
Article CAS PubMed Google Scholar
Kunder, C. A. et al. Mast cell-derived particles deliver peripheral signals to remote lymph nodes. J. Exp. Med. 206, 2455–2467 (2009).
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