The Role of Rosmarinic Acid in the Protection Against Inflammatory Factors in Rats Model With Monocrotaline-Induced Pulmonary Hypertension: Investigating the Signaling Pathway of NFκB, OPG, Runx2, and P-Selectin in Heart

*Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; and

†Persian Gulf Physiology Research Center, Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Correspondence: Mahin Dianat, PhD, Department of Physiology, Faculty of Medicine, Persian Gulf Physiology Research Center, Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Golestan Boulevard, Ahvaz, Iran (e-mail: [email protected]).

Supported by the Persian Gulf Physiology Research Center of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran (Grant No. APRC-0013).

The authors report no conflicts of interest.

M. Dianat and N. Atefipour were responsible for the design of this project. M. Dianat and M. Radan designed the experiments. N. Atefipour and M. Radan collected and processed the data. M. Badavi and S.A. Mard analyzed and interpreted. N. Atefipour wrote the manuscript. The authors declare that all data were generated in-house and that no paper mill was used.

The data used or analyzed during this study are available from the corresponding author upon reasonable request.

The experiments were performed following ethical guidelines. The protocol was confirmed by the local Research Committee at the Ahvaz Jundishapur University of Medical Sciences (No: IRAJUMS.ABHC.REC.1400.064).

All authors have seen and approved the manuscript being submitted, have contributed significantly to the work, attest to the validity and legitimacy of the data and its interpretation, and agree to its submission to the Journal of Cardiovascular Pharmacology.

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