Quercetin Simultaneously Inhibited Cytochrome P450 and P-Glycoprotein to Improve the Pharmacokinetics of Osthole in Rat Plasma

Ashour ML, Youssef FS, Gad HA, Wink M (2017) Inhibition of cytochrome P450 (CYP3A4) activity by extracts from 57 plants used in traditional Chinese medicine (TCM). Pharmacogn Mag 13:300–308. https://doi.org/10.4103/0973-1296.204561

Article  PubMed  PubMed Central  Google Scholar 

Benet LZ, Cummins CL, Wu CY (2004) Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. Int J Pharm 277:3–9. https://doi.org/10.1016/j.ijpharm.2002.12.002

Article  CAS  PubMed  Google Scholar 

Borska S, Sopel M, Chmielewska M, Zabel M, Dziegiel P (2010) Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin. Molecules 15:857–870. https://doi.org/10.3390/molecules15020857

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai H, Luo Y, Yan X, Ding P, Huang Y, Fang S, Zhang R, Chen Y, Guo Z, Fang J, Wang Q, Xu J (2018) The mechanisms of Bushen-Yizhi formula as a therapeutic agent against Alzheimer’s disease. Sci Rep 8:3104. https://doi.org/10.1038/s41598-018-21468-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Liu J, Huang Y, Li R, Ma C, Zhang B, Wu F, Yu W, Zuo X, Liang Y, Wang Q (2021) Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition. Drug Metab Rev 53:491–507. https://doi.org/10.1080/03602532.2021.1917598

Article  CAS  PubMed  Google Scholar 

Chen L, Liao L, Zhai T, Huang X, Chen Y (2019) Influence of orally administered borneol on the expression of hepatic transporters in rats. Eur J Drug Metab Pharmacokinet 44:103–109. https://doi.org/10.1007/s13318-018-0499-1

Article  CAS  PubMed  Google Scholar 

Chiang MC, Tsai TY, Wang CJ (2023) The potential benefits of quercetin for brain health: a review of anti-inflammatory and neuroprotective mechanisms. Int J Mol Sci 24:6328. https://doi.org/10.3390/ijms24076328

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding K, Jia H, Jiang W, Qin Y, Wang Y, Lei M (2023) A double-edged sword: focusing on potential drug-to-drug interactions of quercetin. Rev Bras Farmacogn 33:502–513. https://doi.org/10.1007/s43450-022-00347-6

Article  CAS  Google Scholar 

Garrick JM, Roquè PJ, Pellacani C, Pellacani C (2016) Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more. Oxid Med Cell Longev 2016:2986796. https://doi.org/10.1155/2016/2986796

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo R, Luo X, Liu J, Liu L, Wang X, Lu H (2020) Omics strategies decipher therapeutic discoveries of traditional Chinese medicine against different diseases at multiple layers molecular-level. Pharmacol Res 152:104627. https://doi.org/10.1016/j.phrs.2020.104627

Article  CAS  PubMed  Google Scholar 

Khan H, Ullah H, Aschner M, Cheang WS, Akkol EK (2019) Neuroprotective effects of quercetin in Alzheimer’s disease. Biomolecules 10:59. https://doi.org/10.3390/biom10010059

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim SB, Kang HE, Cho HJ, Kim YS, Chung SJ, Yoon IS, Kim DD (2016) Metabolic interactions of magnolol with cytochrome P450 enzymes: uncompetitive inhibition of CYP1A and competitive inhibition of CYP2C. Drug Dev Ind Pharm 42:263–269. https://doi.org/10.3109/03639045.2015.1047846

Article  CAS  PubMed  Google Scholar 

Liu JM, Chen JM, Lin MJ, Wu FC, Ma CR, Zuo X, Yu WQ, Huang MJ, Fang JS, Li WR, Wang Q, Liang Y (2022) Screening and verification of CYP3A4 inhibitors from Bushen-Yizhi formula to enhance the bioavailability of osthole in rat plasma. J Ethnopharmacol 282:114643. https://doi.org/10.1016/j.jep.2021.114643

Article  CAS  PubMed  Google Scholar 

Liu L, Li P, Qiao L, Li X (2019) Effects of astragaloside IV on the pharmacokinetics of puerarin in rats. Xenobiotica 49:1173–1177. https://doi.org/10.1080/00498254.2018.1480819

Article  CAS  PubMed  Google Scholar 

Liu Y, Luo X, Yang T, Zhou J, Shi S (2016) Impact of quercetin-induced changes in drug-metabolizing enzyme and transporter expression on the pharmacokinetics of cyclosporine in rats. Mol Med Rep 14:3073–3085. https://doi.org/10.3892/mmr.2016.5616

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luan X, Zhang LJ, Li XQ, Ragman K, Zhang H, Chen HZ, Zhang WD (2020) Compound-based Chinese medicine formula: from discovery to compatibility mechanism. J Ethnopharmacol 254:112687. https://doi.org/10.1016/j.jep.2020.112687

Article  CAS  PubMed  Google Scholar 

Ma BL, Ma YM (2016) Pharmacokinetic herb-drug interactions with traditional Chinese medicine: progress, causes of conflicting results and suggestions for future research. Drug Metab Rev 48:1–26. https://doi.org/10.3109/03602532.2015.1124888

Article  CAS  PubMed  Google Scholar 

Mollazadeh S, Sahebkar A, Hadizadeh F, Behravan J, Arabzadeh S (2018) Structural and functional aspects of P-glycoprotein and its inhibitors. Life Sci 214:118–123. https://doi.org/10.1016/j.lfs.2018.10.048

Article  CAS  PubMed  Google Scholar 

Nguyen TTL, Duong VA, Maeng HJ (2021) Pharmaceutical formulations with P-glycoprotein inhibitory effect as promising approaches for enhancing oral drug absorption and bioavailability. Pharmaceutics 13:1103. https://doi.org/10.3390/pharmaceutics13071103

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi J, Fu Q, Chen W, Yang HP, Liu J, Wang XM, He X (2013) Comparative study of pharmacokinetics and tissue distribution of osthole in rats after oral administration of pure osthole and Libanotis buchtormensis supercritical extract. J Ethnopharmacol 145:25–31. https://doi.org/10.1016/j.jep.2012.10.028

Article  CAS  PubMed  Google Scholar 

Sohl CD, Cheng Q, Guengerich FP (2009) Chromatographic assays of drug oxidation by human cytochrome P450 3A4. Nat Protoc 4:1252–1257. https://doi.org/10.1038/nprot.2009.122

Article  CAS  PubMed  Google Scholar 

Wu JJ, Ai CZ, Liu Y, Zhang YY, Jiang M, Fan XR, Lv AP, Yang L (2012) Interactions between phytochemicals from traditional Chinese medicines and human cytochrome P450 enzymes. Curr Drug Metab 13:599–614. https://doi.org/10.2174/1389200211209050599

Article  CAS  PubMed  Google Scholar 

Xiao Q, Liu H, Yang C, Chen Y, Huang Y, Xiao X, Pan YP, He J, Du Q, Wang Q, Zhang YF (2023) Bushen-Yizhi formula exerts neuroprotective effect via inhibiting excessive mitophagy in rats with chronic cerebral hypoperfusion. J Ethnopharmacol 310:116326. https://doi.org/10.1016/j.jep.2023.116326

Article  CAS  PubMed  Google Scholar 

Yu J, Wang Y, Ragueneau-Majlessi I (2022) Pharmacokinetic drug-drug interactions with drugs approved by the US Food and Drug Administration in 2020: mechanistic understanding and clinical recommendations. Drug Metab Dispos 50:1–7. https://doi.org/10.1124/dmd.121.000401

Article  CAS  PubMed  Google Scholar 

Zhang L, Yan R, Su R, Yang C, Liu S, Yu X, Chang X, Zhang S, Liu C, Xu M, Zeng W, Chen Y, Wang Q (2014) Bioavailability enhancement of osthole after oral administration of Bushen Yizhi prescription extract to rats followed by Cnidium monnieri (L.) Cusson fruits extract in comparison to pure osthole at different doses. J Ethnopharmacol 152:266–271. https://doi.org/10.1016/j.jep.2013.09.045

Article  PubMed  Google Scholar 

Zhang SJ, Xu TT, Li L, Xu YM, Qu ZL, Wang XC, Huang SQ, Luo Y, Luo NC, Lu P, Shi YF, Yang X, Wang Q (2017) Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice. Oncotarget 8:49338–49350. https://doi.org/10.18632/oncotarget.17638

Article  PubMed  PubMed Central  Google Scholar 

Zhang ZR, Leung WN, Cheung HY, Chan CW (2015) Osthole: a review on its bioactivities, pharmacological properties, and potential as alternative medicine. Evid Based Complement Alternat Med 2015:919616. https://doi.org/10.1155/2015/919616

Article  PubMed  PubMed Central  Google Scholar 

Zhao G, Peng C, Du W, Wang S (2013) Pharmacokinetic study of eight coumarins of Radix Angelicae Dahuricae in rats by gas chromatography-mass spectrometry. Fitoterapia 89:250–256. https://doi.org/10.1016/j.fitote.2013.06.007

Article  CAS  PubMed  Google Scholar 

Zhao Q, Li XM, Liu HN, Gonzalez FJ, Li F (2018) Metabolic map of osthole and its effect on lipids. Xenobiotica 48:285–299. https://doi.org/10.1080/00498254.2017.1306660

Article  CAS  PubMed  Google Scholar 

Zhao M, Ma J, Li M, Zhang Y, Jiang B, Zhao X, Huai C, Shen L, Zhang N, He L, Qin S (2021) Cytochrome P450 enzymes and drug metabolism in humans. Int J Mol Sci 22:21808. https://doi.org/10.3390/ijms222312808

Article  CAS  Google Scholar 

留言 (0)

沒有登入
gif