Alanís AD, Calzada F, Cedillo-Rivera R, Meckes M (2003) Antiprotozoal activity of the constituents of Rubus coriifolius. Phytother Res 17:681–682. https://doi.org/10.1002/ptr.1150

Article  CAS  PubMed  Google Scholar 

Ansell BR, McConville MJ, Ma’ayeh SY, Dagley MJ, Gasser RB, SvärdSG, Jex AR, (2015) Drug resistance in Giardia duodenalis. Biotechnol Adv 33:888–901. https://doi.org/10.1016/j.biotechadv.2015.04.009

Article  CAS  PubMed  Google Scholar 

Antonić B, Jančíková S, Dordević D, Tremlová B (2020) Grape pomace valorization: a systematic review and meta-qnalysis. Foods 9:1627. https://doi.org/10.3390/foods9111627

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anza M, Endale M, Cardona L, Cortes D, Eswaramoorthy R, Zueco J, Abarca B (2021) Antimicrobial activity, in silico molecular docking, ADMET and DFT analysis of secondary metabolites from roots of three ethiopian medicinal plants. Adv Appl Bioinform Chem: AABC 14:117–132. https://doi.org/10.2147/AABC.S323657

Article  PubMed  PubMed Central  Google Scholar 

Argüello-García R, Calzada F, García N, Chávez-Munguia B, Dominguez J (2020) Ultrastructural and proapoptotic-like effects of kaempferol in Giardia duodenalis trophozoites and bioinformatics prediction of its potential protein target. Mem Inst Oswaldo Cruz 115. https://doi.org/10.1590/0074-02760200127

Arnott JA, Planey SL (2012) The influence of lipophilicity in drug discovery and design. Expert Opin Drug Discov 7:863–875. https://doi.org/10.1517/17460441.2012.714363

Article  CAS  PubMed  Google Scholar 

Ascacio-Valdés JA, Aguilera-Carbó AF, Buenrostro JJ, Prado-Barragán A, Rodríguez-Herrera R, Aguilar CN (2016) The complete biodegradation pathway of ellagitannins by Aspergillus niger in solid-state fermentation. J Basic Microb 56:329–336. https://doi.org/10.1002/jobm.201500557

Article  CAS  Google Scholar 

Aziz AFE, Roshidi N, Othman N, Mohd Hanafiah K, Arifin N (2022) Application of proteomics to the study of the therapeutics and pathogenicity of Giardia duodenalis. Diagnostics 12:2744. https://doi.org/10.3390/diagnostics12112744

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balbinoti TCV, Stafussa AP, Haminiuk CWI, Maciel GM, Sassaki GL, Jorge LMdM, Jorge RMM (2020) Addition of grape pomace in the hydration step of parboiling increases the antioxidant properties of rice. Int J of Food Sci Tech 55:2370–2380. https://doi.org/10.1111/ijfs.14481

Article  CAS  Google Scholar 

Barbosa E, Calzada F, Campos R (2007) In vivo antigiardial activity of three flavonoids isolated of some medicinal plants used in Mexican traditional medicine for the treatment of diarrhea. J Ethnopharmacol 109:552–554. https://doi.org/10.1016/j.jep.2006.09.009

Article  CAS  PubMed  Google Scholar 

Benkert P, Tosatto SCE, Schomburg D (2008) QMEAN: a comprehensive scoring function for model quality assessment. Proteins 71:261–277. https://doi.org/10.1002/prot.21715

Article  CAS  PubMed  Google Scholar 

Bertiaux E, Bastin P (2020) Dealing with several flagella in the same cell. Cell Microbiol 22:e13162. https://doi.org/10.1111/cmi.13162

Article  CAS  PubMed  Google Scholar 

Bienert S, Waterhouse A, de Beer Tjaart AP, Tauriello G, Studer G, Bordoli L, Schwede T (2016) The SWISS-MODEL Repository—new features and functionality. Nucleic Acids Res 45:D313–D319. https://doi.org/10.1093/nar/gkw1132

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calzada F, Cervantes-Martínez JA, Yépez-Mulia L (2005) In vitro antiprotozoal activity from the roots of Geranium mexicanum and its constituents on Entamoeba histolytica and Giardia lamblia. J Ethnopharmacol 98:191–193. https://doi.org/10.1016/j.jep.2005.01.019

Article  CAS  PubMed  Google Scholar 

Campanati L, Troester H, Monteiro-Leal LH, Spring H, Trendelenburg MF, de Souza W (2003) Tubulin diversity in trophozoites of Giardia lamblia. Histochem Cell Biol 119:323–331. https://doi.org/10.1007/s00418-003-0517-4

Caponio GR, Noviello M, Calabrese FM, Gambacorta G, Giannelli G, De Angelis M (2022) Effects of grape pomace polyphenols and in vitro gastrointestinal digestion on antimicrobial activity: recovery of bioactive compounds. Antioxidants 11:567. https://doi.org/10.3390/antiox11030567

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ceramella J, La Torre C, De Luca M, Iacopetta D, Fazio A, Catalano A, Rosano C (2022) Exploring the anticancer and antioxidant properties of Vicia faba L. pods extracts, a promising source of nutraceuticals. PeerJ 10:e13683. https://doi.org/10.7717/peerj.13683

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colovos C, Yeates TO (1993) Verification of protein structures: patterns of nonbonded atomic interactions. Protein Sci 2:1511–1519. https://doi.org/10.1002/pro.5560020916

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ćućuz V, Cvejić J, Torović L, Gojković-Bukarica L, Acevska J, Dimitrovska A, Galanakis CM (2022) Design of experiments (DoE) to model phenolic compounds recovery from grape pomace using ultrasounds. J Food Sci Techn 59:2913–2924. https://doi.org/10.1007/s13197-021-05317-9

Article  CAS  Google Scholar 

Ćurko N, Kelšin K, Dragović-Uzelac V, Valinger D, Tomašević M, Kovačević Ganić K (2019) Microwave-assisted extraction of different groups of phenolic compounds from grape skin pomaces: modeling and optimization. Pol J Food Nutr Sci 69:235–246. https://doi.org/10.31883/pjfns/109423

Article  CAS  Google Scholar 

Daina A, Michielin O, Zoete V (2017) SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep 7:42717. https://doi.org/10.1038/srep42717

Article  ADS  PubMed  PubMed Central  Google Scholar 

Dawson SC, House SA (2010) Life with eight flagella: flagellar assembly and division in Giardia. Curr Opin Microbiol 13:480–490. https://doi.org/10.1016/j.mib.2010.05.014

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dawson SC, Sagolla MS, Mancuso JJ, Woessner DJ, House SA, Fritz-Laylin L, Cande WZ (2007) Kinesin-13 regulates flagellar, interphase, and mitotic microtubule dynamics in Giardia intestinalis. Eukaryot Cell 6:2354–2364. https://doi.org/10.1128/ec.00128-07

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dingsdag SA, Hunter N (2017) Metronidazole: an update on metabolism, structure–cytotoxicity and resistance mechanisms. J Antimicrob Chemoth 73:265–279. https://doi.org/10.1093/jac/dkx351

Article  CAS  Google Scholar 

Doak BC, Over B, Giordanetto F, Kihlberg J (2014) Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates. Chem Biol 21:1115–1142. https://doi.org/10.1016/j.chembiol.2014.08.013

Article  CAS  PubMed  Google Scholar 

Egan WJ, Merz KM, Baldwin JJ (2000) Prediction of drug absorption using multivariate statistics. J Med Chem 43:3867–3877. https://doi.org/10.1021/jm000292e

Article  CAS  PubMed  Google Scholar 

El-Baky NA, Amara ABAF (2023) Natural antimicrobial therapeutic peptides. In: Gupta A (ed) Antimicrobials in pharmaceutical and medicinal research. CRC Press, Boca Ratton, pp 19–47

Chapter  Google Scholar 

El-Kady AM, Abdel-Rahman IAM, Fouad SS, Allemailem KS, Istivan T, Ahmed SFM, Elshabrawy HA (2021) Pomegranate peel extract is a potential alternative therapeutic for giardiasis. Antibiotics 10:705. https://doi.org/10.3390/antibiotics10060705

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elkholy WA, Elkholy MA, Elsokary AN, Alshehri E, Al-Quraishy S, Abdel-Gaber R, Shaheen HAA (2022) Therapeutic and prophylactic effects of Punica granatum peel extract versus metronidazole in murine giardiasis intestinalis. J King Saud Univ Sci 34:102321. https://doi.org/10.1016/j.jksus.2022.102321

Article  Google Scholar 

Fang F, Li JM, Pan QH, Huang WD (2007) Determination of red wine flavonoids by HPLC and effect of aging. Food Chem 101:428–433. https://doi.org/10.1016/j.foodchem.2005.12.036

Article  CAS  Google Scholar 

Friedman M, Tam CC, Cheng LW, Land KM (2020) Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review. BMC Complement Med Ther 20:271. https://doi.org/10.1186/s12906-020-03061-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gadelha APR, Bravim B, Vidal J, Reignault LC, Cosme B, Huber K, de Souza W (2019) Alterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitor. Int J Med Microbiol 309:130–142. https://doi.org/10.1016/j.ijmm.2019.01.002

Article  CAS  PubMed  Google Scholar 

Gadelha APR, Benchimol M, de Souza W (2020) Chapter One - The structural organization of Giardia intestinalis cytoskeleton. In Ortega-Pierres MG (Ed.), Adv Parasit (107:1–23): Academic Press

Galvão BVD, Araujo-Lima CF, Santos M, Seljan MP, Carrão-Dantas EK, Aiub CAF, Felzenszwalb I (2021) Plinia cauliflora (Mart.) Kausel (Jaboticaba) leaf extract: in vitro anti-Trypanosoma cruzi activity, toxicity assessment and phenolic-targeted UPLC-MS(E) metabolomic analysis. J Ethnopharmacol 277:114217. https://doi.org/10.1016/j.jep.2021.114217

Article  CAS  PubMed  Google Scholar 

Gérard-Monnier D, Erdelmeier I, Régnard K, Moze-Henry N, Yadan JC, Chaudière J (1998) Reactions of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Analytical applications to a colorimetric assay of lipid peroxidation. Chem Res Toxicol 11:1176–1183. https://doi.org/10.1021/tx9701790

Article  PubMed