Schmahmann JD, Guell X, Stoodley CJ, Halko MA. The Theory and Neuroscience of Cerebellar Cognition. Annu Rev Neurosci. 2019;42:337–64.

Article  CAS  Google Scholar 

Rancz EA, Ishikawa T, Duguid I, Chadderton P, Mahon S, et al. High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons. Nature. 2007;450:1245–8.

Article  ADS  CAS  Google Scholar 

Arenz A, Silver RA, Schaefer AT, Margrie TW. The contribution of single synapses to sensory representation in vivo. Science. 2008;321:977–80.

Article  ADS  CAS  Google Scholar 

Batchelor AM, Garthwaite J. Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway. Nature. 1997;385:74–7.

Article  ADS  CAS  Google Scholar 

Canepari M, Papageorgiou G, Corrie JE, Watkins C, Ogden D. The conductance underlying the parallel fibre slow EPSP in rat cerebellar Purkinje neurones studied with photolytic release of L-glutamate. J Physiol. 2001;533:765–72.

Article  CAS  Google Scholar 

Hartmann J, Dragicevic E, Adelsberger H, Henning HA, Sumser M, et al. TRPC3 channels are required for synaptic transmission and motor coordination. Neuron. 2008;59:392–8.

Article  CAS  Google Scholar 

Canepari M, Auger C, Ogden D. Ca2+ ion permeability and single-channel properties of the metabotropic slow EPSC of rat Purkinje neurons. J Neurosci. 2004;24:3563–73.

Article  CAS  Google Scholar 

Becker EB, Oliver PL, Glitsch MD, Banks GT, Achilli F, et al. A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice. Proc Natl Acad Sci U S A. 2009;106:6706–11.

Article  ADS  CAS  Google Scholar 

Skibinska-Kijek A, Wisniewska MB, Gruszczynska-Biegala J, Methner A, Kuznicki J. Immunolocalization of STIM1 in the mouse brain. Acta Neurobiol Exp (Wars). 2009;69:413–28.

Article  Google Scholar 

Zeng W, Yuan JP, Kim MS, Choi YJ, Huang GN, et al. STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell. 2008;32:439–48.

Article  CAS  Google Scholar 

Lee KP, Choi S, Hong JH, Ahuja M, Graham S, et al. Molecular determinants mediating gating of Transient Receptor Potential Canonical (TRPC) channels by stromal interaction molecule 1 (STIM1). J Biol Chem. 2014;289:6372–82.

Article  CAS  Google Scholar 

Hartmann J, Karl RM, Alexander RP, Adelsberger H, Brill MS, et al. STIM1 controls neuronal Ca(2)(+) signaling, mGluR1-dependent synaptic transmission, and cerebellar motor behavior. Neuron. 2014;82:635–44.

Article  CAS  Google Scholar 

Jin Y, Kim SJ, Kim J, Worley PF, Linden DJ. Long-term depression of mGluR1 signaling. Neuron. 2007;55:277–87.

Article  CAS  Google Scholar 

Ishibashi K, Miura Y, Ishikawa K, Zhang MR, Toyohara J, et al. Relationship between type 1 metabotropic glutamate receptors and cerebellar ataxia. J Neurol. 2016;263:2179–87.

Article  CAS  Google Scholar 

Shuvaev AN, Hosoi N, Sato Y, Yanagihara D, Hirai H. Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice. J Physiol. 2017;595:141–64.

Article  CAS  Google Scholar 

Egorova PA, Marinina KS, Bezprozvanny IB. Chronic suppression of STIM1-mediated calcium signaling in Purkinje cells rescues the cerebellar pathology in spinocerebellar ataxia type 2. Biochim Biophys Acta Mol Cell Res. 2023;1870: 119466.

Article  CAS  Google Scholar 

Abbott LC, Nahm SS. Neuronal nitric oxide synthase expression in cerebellar mutant mice. Cerebellum. 2004;3:141–51.

Article  CAS  Google Scholar 

Broillet MC. S-nitrosylation of proteins. Cell Mol Life Sci. 1999;55:1036–42.

Article  CAS  Google Scholar 

Linden DJ, Dawson TM, Dawson VL. An evaluation of the nitric oxide/cGMP/cGMP-dependent protein kinase cascade in the induction of cerebellar long-term depression in culture. J Neurosci. 1995;15:5098–105.

Article  CAS  Google Scholar 

Lev-Ram V, Nebyelul Z, Ellisman MH, Huang PL, Tsien RY. Absence of cerebellar long-term depression in mice lacking neuronal nitric oxide synthase. Learn Mem. 1997;4:169–77.

Article  CAS  Google Scholar 

Kriegsfeld LJ, Eliasson MJ, Demas GE, Blackshaw S, Dawson TM, et al. Nocturnal motor coordination deficits in neuronal nitric oxide synthase knock-out mice. Neuroscience. 1999;89:311–5.

Article  CAS  Google Scholar 

Katoh A, Kitazawa H, Itohara S, Nagao S. Inhibition of nitric oxide synthesis and gene knockout of neuronal nitric oxide synthase impaired adaptation of mouse optokinetic response eye movements. Learn Mem. 2000;7:220–6.

Article  CAS  Google Scholar 

Tellios V, Maksoud MJE, Xiang YY, Lu WY. Nitric Oxide Critically Regulates Purkinje Neuron Dendritic Development Through a Metabotropic Glutamate Receptor Type 1-Mediated Mechanism. Cerebellum. 2020;19:510–26.

Article  CAS  Google Scholar 

Llano I, Marty A, Armstrong CM, Konnerth A. Synaptic- and agonist-induced excitatory currents of Purkinje cells in rat cerebellar slices. J Physiol. 1991;434:183–213.

Article  CAS  Google Scholar 

Dzubay JA, Otis TS. Climbing fiber activation of metabotropic glutamate receptors on cerebellar purkinje neurons. Neuron. 2002;36:1159–67.

Article  CAS  Google Scholar 

Konnerth A, Llano I, Armstrong CM. Synaptic currents in cerebellar Purkinje cells. Proc Natl Acad Sci U S A. 1990;87:2662–5.

Article  ADS  CAS  Google Scholar 

Yu F, Zhong P, Liu X, Sun D, Gao HQ, et al. Metabotropic glutamate receptor I (mGluR1) antagonism impairs cocaine-induced conditioned place preference via inhibition of protein synthesis. Neuropsychopharmacology. 2013;38:1308–21.

Article  CAS  Google Scholar 

Abdoul-Azize S, Buquet C, Vannier JP, Dubus I. Pyr3, a TRPC3 channel blocker, potentiates dexamethasone sensitivity and apoptosis in acute lymphoblastic leukemia cells by disturbing Ca(2+) signaling, mitochondrial membrane potential changes and reactive oxygen species production. Eur J Pharmacol. 2016;784:90–8.

Article  CAS  Google Scholar 

Maksoud MJE, Tellios V, An D, Xiang YY, Lu WY. Nitric oxide upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane. Glia. 2019;67:2294–311.

Article  Google Scholar 

Januzi L, Poirier JW, Maksoud MJE, Xiang YY, Veldhuizen RAW, et al. Autocrine GABA signaling distinctively regulates phenotypic activation of mouse pulmonary macrophages. Cell Immunol. 2018;332:7–23.

Article  CAS  Google Scholar 

Dong H, Kumar M, Zhang Y, Gyulkhandanyan A, Xiang YY, et al. Gamma-aminobutyric acid up- and downregulates insulin secretion from beta cells in concert with changes in glucose concentration. Diabetologia. 2006;49:697–705.

Article  CAS  Google Scholar 

Feng AL, Xiang YY, Gui L, Kaltsidis G, Feng Q, et al. Paracrine GABA and insulin regulate pancreatic alpha cell proliferation in a mouse model of type 1 diabetes. Diabetologia. 2017;60:1033–42.

Article  CAS  Google Scholar 

Baptista CA, Hatten ME, Blazeski R, Mason CA. Cell-cell interactions influence survival and differentiation of purified Purkinje cells in vitro. Neuron. 1994;12:243–60.

Article  CAS  Google Scholar 

Morrison ME, Mason CA. Granule neuron regulation of Purkinje cell development: striking a balance between neurotrophin and glutamate signaling. J Neurosci. 1998;18:3563–73.

Article  CAS  Google Scholar 

Chen WK, Liu IY, Chang YT, Chen YC, Chen CC, et al. Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J Neurosci. 2010;30:10360–8.

Article  CAS  Google Scholar 

Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012;9:676–82.

Article  CAS  Google Scholar 

Stathopulos PB, Zheng L, Li GY, Plevin MJ, Ikura M. Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry. Cell. 2008;135:110–22.

Article  CAS  Google Scholar 

Lavreysen H, Wouters R, Bischoff F, Nobrega Pereira S, Langlois X, et al. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology. 2004;47:961–72.

Article  CAS  Google Scholar 

Kiyonaka S, Kato K, Nishida M, Mio K, Numaga T, et al. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009;106:5400–5.

Article  ADS  CAS  Google Scholar 

Wu B, Blot FG, Wong AB, Osorio C, Adolfs Y, et al. (2019) TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells. Elife 8. https://doi.org/10.7554/eLife.45590

Harbers M, Nakao H, Watanabe T, Matsuyama K, Tohyama S, et al. (2022) mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning. Cells 11. https://doi.org/10.3390/cells11132004

Sukumaran P, Sun Y, Vyas M, Singh BB. TRPC1-mediated Ca(2)(+) entry is essential for the regulation of hypoxia and nutrient depletion-dependent autophagy. Cell Death Dis. 2015;6: e1674.

Article  CAS  Google Scholar 

Gui L, Zhu J, Lu X, Sims SM, Lu WY, et al. S-Nitrosylation of STIM1 by Neuronal Nitric Oxide Synthase Inhibits Store-Operated Ca(2+) Entry. J Mol Biol. 2018;430:1773–85.

Article  CAS