Broen MPG, Smits M, Wijnenga MMJ et al (2018) The T2-FLAIR mismatch sign as an imaging marker for non-enhancing IDH-mutant, 1p/19q-intact lower-grade glioma: a validation study. Neuro Oncol 20:1393–1399. https://doi.org/10.1093/neuonc/noy048

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel SH, Poisson LM, Brat DJ et al (2017) T2-FLAIR mismatch, an imaging biomarker for IDH and 1p/19q status in lower-grade gliomas: a TCGA/TCIA project. Clin Cancer Res 23:6078–6085. https://doi.org/10.1158/1078-0432.CCR-17-0560

Article  CAS  PubMed  Google Scholar 

Juratli TA, Tummala SS, Riedl A et al (2019) Radiographic assessment of contrast enhancement and T2/FLAIR mismatch sign in lower grade gliomas: correlation with molecular groups. J Neurooncol 141:327–335. https://doi.org/10.1007/s11060-018-03034-6

Article  CAS  PubMed  Google Scholar 

Jain R, Johnson DR, Patel SH et al (2020) “Real world” use of a highly reliable imaging sign: “T2-FLAIR mismatch” for identification of IDH mutant astrocytomas. Neuro Oncol 22:936–943. https://doi.org/10.1093/neuonc/noaa041

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnson DR, Kaufmann TJ, Patel SH et al (2019) There is an exception to every rule—T2-FLAIR mismatch sign in gliomas. Neuroradiology 61:225–227. https://doi.org/10.1007/s00234-018-2148-4

Article  PubMed  Google Scholar 

Pinto C, Noronha C, Taipa R, Ramos C (2022) T2-FLAIR mismatch sign: a roadmap of pearls and pitfalls. Br J Radiol 95:20210825. https://doi.org/10.1259/bjr.20210825

Article  PubMed  Google Scholar 

Lasocki A, Gaillard F, Gorelik A, Gonzales M (2018) MRI features can predict 1p/19q Status in intracranial gliomas. Am J Neuroradiol 39:687–692. https://doi.org/10.3174/ajnr.A5572

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee MD, Patel SH, Mohan S et al (2023) Association of partial T2-FLAIR mismatch sign and isocitrate dehydrogenase mutation in WHO grade 4 gliomas: results from the ReSPOND consortium. Neuroradiology 65:1343–1352. https://doi.org/10.1007/s00234-023-03196-9

Article  PubMed  Google Scholar 

Nakasu S, Deguchi S, Nakasu Y (2023) IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis. Brain Tumor Pathol. https://doi.org/10.1007/s10014-023-00463-8

Article  PubMed  Google Scholar 

Kibe Y, Motomura K, Ohka F et al (2023) Imaging features of localized IDH wild-type histologically diffuse astrocytomas: a single-institution case series. Sci Rep 13:23. https://doi.org/10.1038/s41598-022-25928-2

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Rudà R, Bruno F, Ius T et al (2021) IDH wild-type grade 2 diffuse astrocytomas: prognostic factors and impact of treatments within molecular subgroups. Neuro Oncol 24:809–820. https://doi.org/10.1093/neuonc/noab239

Article  PubMed Central  Google Scholar 

Tay KL, Tsui A, Phal PM et al (2011) MR imaging characteristics of protoplasmic astrocytomas. Neuroradiology 53:405–411. https://doi.org/10.1007/s00234-010-0741-2

Article  PubMed  Google Scholar 

Franceschi E, De Biase D, Di Nunno V et al (2021) IDH1 non-canonical mutations and survival in patients with glioma. Diagnostics 11:342. https://doi.org/10.3390/diagnostics11020342

Karsy M, Guan J, Cohen AL et al (2017) New molecular considerations for glioma: IDH, ATRX, BRAF, TERT, H3 K27M. Curr Neurol Neurosci Rep 17:19. https://doi.org/10.1007/s11910-017-0722-5

Article  PubMed  Google Scholar 

Lee S, Lee DK (2018) What is the proper way to apply the multiple comparison test? Korean J Anesthesiol 71:353–360. https://doi.org/10.4097/kja.d.18.00242

Article  PubMed  PubMed Central  Google Scholar 

Mayson TA, Ward V, Davies KR et al (2013) Reliability of retrospective assignment of gross motor function classification system scores. Dev Neurorehabil 16:207–209. https://doi.org/10.3109/17518423.2012.755575

Article  CAS  PubMed  Google Scholar 

Poetsch L, Bronnimann C, Loiseau H et al (2021) Characteristics of IDH-mutant gliomas with non-canonical IDH mutation. J Neurooncol 151:279–286. https://doi.org/10.1007/s11060-020-03662-x

Article  CAS  PubMed  Google Scholar 

Park YW, Han K, Ahn SS et al (2018) Prediction of IDH1-mutation and 1p/19q-codeletion status using preoperative MR imaging phenotypes in lower grade gliomas. AJNR Am J Neuroradiol 39:37–42. https://doi.org/10.3174/ajnr.A5421

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lotan E, Jain R, Razavian N et al (2019) State of the art: machine learning applications in glioma imaging. Am J Roentgenol 212:26–37. https://doi.org/10.2214/AJR.18.20218

Article  Google Scholar 

Deguchi S, Oishi T, Mitsuya K et al (2020) Clinicopathological analysis of T2-FLAIR mismatch sign in lower-grade gliomas. Sci Rep 10:10113. https://doi.org/10.1038/s41598-020-67244-7

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Yamashita S, Takeshima H, Kadota Y et al (2023) P03.03.A T2-fluid-attenuated inversion recovery mismatch sign in lower-grade gliomas: correlation with pathological and molecular findings. Neuro-Oncology 25:ii36–ii37. https://doi.org/10.1093/neuonc/noad137.114

Article  Google Scholar 

Vasef MA, Auerbach A, Czuchlewski DR et al (2016) Low-grade astrocytoma. Diagnostic Pathology: molecular oncology. Elsevier, Philadelphia, pp 8–386

Google Scholar 

Lasocki A, Buckland ME, Molinaro T et al (2023) Correlating MRI features with additional genetic markers and patient survival in histological grade 2–3 IDH-mutant astrocytomas. Neuroradiology 65:1215–1223. https://doi.org/10.1007/s00234-023-03175-0

Article  PubMed  PubMed Central  Google Scholar 

Johnson DR, Giannini C, Vaubel RA et al (2022) A radiologist’s guide to the 2021 WHO Central nervous system tumor classification: part I—key concepts and the spectrum of diffuse gliomas. Radiology 304:494–508. https://doi.org/10.1148/radiol.213063

Article  PubMed  Google Scholar 

Liu X-Y, Gerges N, Korshunov A et al (2012) Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations. Acta Neuropathol 124:615–625. https://doi.org/10.1007/s00401-012-1031-3

Article  CAS  PubMed  Google Scholar 

Banan R, Stichel D, Bleck A et al (2020) Infratentorial IDH-mutant astrocytoma is a distinct subtype. Acta Neuropathol 140:569–581. https://doi.org/10.1007/s00401-020-02194-y

Article  CAS  PubMed  Google Scholar 

Nagase T, Ishida J, Sasada S et al (2023) IDH-mutant astrocytoma arising in the brainstem with symptom improvement by foramen magnum decompression: a case report. NMC Case Rep J 10:75–80. https://doi.org/10.2176/jns-nmc.2022-0159

Article  PubMed  PubMed Central  Google Scholar 

Ye VC, Landry AP, Purzner T et al (2021) Adult isocitrate dehydrogenase-mutant brainstem glioma: illustrative case. J Neurosurg Case Lessons 1(12):CASE2078. https://doi.org/10.3171/CASE2078

Babikir H, Wang L, Shamardani K et al (2021) ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma. Genome Biol 22:311. https://doi.org/10.1186/s13059-021-02535-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Richard Q, Laurenge A, Mallat M et al (2022) New insights into the immune TME of adult-type diffuse gliomas. Curr Opin Neurol 35:794. https://doi.org/10.1097/WCO.0000000000001112

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qin T, Mullan B, Ravindran R et al (2022) ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization. Cell Rep 38:110216. https://doi.org/10.1016/j.celrep.2021.110216

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parmar HA, Hawkins C, Ozelame R et al (2007) Fluid-attenuated inversion recovery ring sign as a marker of dysembryoplastic neuroepithelial tumors. J Comput Assist Tomogr 31:348–353. https://doi.org/10.1097/01.rct.0000243453.33610.9d

Article  PubMed  Google Scholar 

Chen W, Jin S, Liu Q et al (2023) Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumors. Front Neurosci 17:1144559. https://doi.org/10.3389/fnins.2023.1144559

da Silva JFC, de Souza Machado GH, Pedro MKF et al (2019) Angiocentric glioma: literature review and first case in Brazil. Interdiscip Neurosurg 18:100508. https://doi.org/10.1016/j.inat.2019.100508

Article  Google Scholar 

Wefers AK, Stichel D, Schrimpf D et al (2020) Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course. Acta Neuropathol 139:193–209. https://doi.org/10.1007/s00401-019-02078-w

Article  PubMed  Google Scholar 

Kinoshita M, Arita H, Takahashi M et al (2020) Impact of inversion time for FLAIR acquisition on the T2-FLAIR mismatch detectability for IDH-mutant, non-CODEL astrocytomas. Front Oncol 10:596448. https://doi.org/10.3389/fonc.2020.596448

Article  PubMed  Google Scholar 

Kinoshita M, Uchikoshi M, Sakai M et al (2020) T2-FLAIR mismatch sign is caused by long T1 and T2 of IDH-mutant, 1p19q non-codeleted astrocytoma. Magn Reson Med Sci 20:119–123. https://doi.org/10.2463/mrms.bc.2019-0196

Article  CAS