Dr. Mirzai is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health (T32HL076132). Drs. Mirzai and Chen are partially supported by the Cleveland Clinic Philanthropy Institute?s Caregiver Catalyst Grant and the Musculoskeletal Research Center’s Pilot Project Program Grant. Dr. Tang is partially supported by grants from the National Institutes of Health (R01HL146754). Dr. Tang served as a consultant for Sequana Medical, Cardiol Therapeutics, Genomics plc, Zehna Therapeutics, WhiteSwell, Kiniksa Pharmaceutical, Boston Scientific, CardiaTec Biosciences, Intellia Therapeutics, Bristol Myers Squibb, Alleviant Medical, and has received an honorarium from Springer Nature, Belvoir Publishing, and American Board of Internal Medicine ? all unrelated to current study. All other authors have no relationships to disclose.