Conn, D. L. The story behind the use of glucocorticoids in the treatment of rheumatoid arthritis. Semin. Arthritis Rheum. 51, 15–19 (2021).
Article CAS PubMed Google Scholar
Cain, D. W. & Cidlowski, J. A. Immune regulation by glucocorticoids. Nat. Rev. Immunol. 17, 233–247 (2017).
Article CAS PubMed PubMed Central Google Scholar
McLornan, D. P., Pope, J. E., Gotlib, J. & Harrison, C. N. Current and future status of JAK inhibitors. Lancet 398, 803–816 (2021).
O’Shea, J. J. & Gadina, M. Selective Janus kinase inhibitors come of age. Nat. Rev. Rheumatol. 15, 74–75 (2019).
Liu, C., Kieltyka, J., Fleischmann, R., Gadina, M. & O’Shea, J. J. A decade of JAK inhibitors: what have we learned and what may be the future? Arthritis Rheumatol. 73, 2166–2178 (2021).
Article CAS PubMed PubMed Central Google Scholar
Shuai, K. & Liu, B. Regulation of JAK-STAT signalling in the immune system. Nat. Rev. Immunol. 3, 900–911 (2003).
Article CAS PubMed Google Scholar
Strobl, B., Stoiber, D., Sexl, V. & Mueller, M. Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity. Front. Biosci. 16, 3214–3232 (2011).
Burke, J. R. et al. Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain. Sci. Transl. Med. 11 (2019).
Fuchs, S. et al. Tyrosine kinase 2 is not limiting human antiviral type III interferon responses. Eur. J. Immunol. 46, 2639–2649 (2016).
Article CAS PubMed Google Scholar
Teng, M. W. et al. IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat. Med. 21, 719–729 (2015).
Article CAS PubMed Google Scholar
Yang, K., Oak, A. S. W. & Elewski, B. E. Use of IL-23 inhibitors for the treatment of plaque psoriasis and psoriatic arthritis: a comprehensive review. Am. J. Clin. Dermatol. 22, 173–192 (2021).
Singh, J. A. et al. 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis. Arthritis Rheumatol. 71, 5–32 (2019).
Gossec, L. et al. EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update. Ann. Rheum. Dis. 79, 700–712 (2020).
Menter, A. et al. Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics. J. Am. Acad. Dermatol. 80, 1029–1072 (2019).
Sarabia, S., Ranjith, B., Koppikar, S. & Wijeratne, D. T. Efficacy and safety of JAK inhibitors in the treatment of psoriasis and psoriatic arthritis: a systematic review and meta-analysis. BMC Rheumatol. 6, 71 (2022).
Article PubMed PubMed Central Google Scholar
Morand, E. F. et al. Trial of anifrolumab in active systemic lupus erythematosus. N. Engl. J. Med. 382, 211–221 (2020).
Article CAS PubMed Google Scholar
Furie, R. A. et al. Type I interferon inhibitor anifrolumab in active systemic lupus erythematosus (TULIP-1): a randomised, controlled, phase 3 trial. Lancet Rheumatol. 1, e208–e219 (2019).
Kalunian, K. C. et al. A randomized, placebo-controlled phase III extension trial of the long-term safety and tolerability of anifrolumab in active systemic lupus erythematosus. Arthritis Rheumatol. 75, 253–265 (2023).
Article CAS PubMed Google Scholar
Hagberg, N. et al. The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE. Ann. Rheum. Dis. 77, 1070–1077 (2018).
Article CAS PubMed Google Scholar
Parkes, M., Cortes, A., van Heel, D. A. & Brown, M. A. Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat. Rev. Genet. 14, 661–673 (2013).
Article CAS PubMed Google Scholar
Sigurdsson, S. et al. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. Am. J. Hum. Genet. 76, 528–537 (2005).
Article CAS PubMed PubMed Central Google Scholar
Cunninghame Graham, D. S. et al. Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus. PLoS Genet. 7, e1002341 (2011).
Article CAS PubMed PubMed Central Google Scholar
Yin, Q. et al. Comprehensive assessment of the association between genes on JAK-STAT pathway (IFIH1, TYK2, IL-10) and systemic lupus erythematosus: a meta-analysis. Arch. Dermatol. Res. 310, 711–728 (2018).
Article CAS PubMed Google Scholar
Diogo, D. et al. TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits. PLoS One 10, e0122271 (2015).
Article PubMed PubMed Central Google Scholar
Lopez-Isac, E. et al. Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway. Ann. Rheum. Dis. 75, 1521–1526 (2016).
Article CAS PubMed Google Scholar
Bossini-Castillo, L. et al. A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Hum. Mol. Genet. 21, 926–933 (2012).
Article CAS PubMed Google Scholar
Hu, L. et al. Interleukin-22 from type 3 innate lymphoid cells aggravates lupus nephritis by promoting macrophage infiltration in lupus-prone mice. Front. Immunol. 12, 584414 (2021).
Article CAS PubMed PubMed Central Google Scholar
Yang, X. et al. Increased interleukin-22 levels in lupus nephritis and its associated with disease severity: a study in both patients and lupus-like mice model. Clin. Exp. Rheumatol. 37, 400–407 (2018).
Jani, M. et al. Genotyping of immune-related genetic variants identifies TYK2 as a novel associated locus for idiopathic inflammatory myopathies. Ann. Rheum. Dis. 73, 1750–1752 (2014).
Hromadova, D., Elewaut, D., Inman, R. D., Strobl, B. & Gracey, E. From science to success? targeting tyrosine kinase 2 in spondyloarthritis and related chronic inflammatory diseases. Front. Genet. 12, 685280 (2021).
Article CAS PubMed PubMed Central Google Scholar
Takeda. Takeda announces positive results in phase 2b study of investigational TAK-279, an oral, once-daily TYK2 inhibitor, in people with moderate-to-severe plaque psoriasis [press release]. Takeda.com https://www.takeda.com/newsroom/newsreleases/2023/takeda-announces-positive-results-in-phase-2b-study-of-investigational-tak-279/ (2023).
Papp, K. et al. Phase 2 trial of selective tyrosine kinase 2 inhibition in psoriasis. N. Engl. J. Med. 379, 1313–1321 (2018).
Article CAS PubMed Google Scholar
Armstrong, A. W. et al. Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial. J. Am. Acad. Dermatol. 88, 29–39 (2023).
Article CAS PubMed Google Scholar
Strober, B. et al. Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: efficacy and safety results from the 52-week, randomized, double-blinded, phase 3 Program for Evaluation of TYK2 inhibitor psoriasis second trial. J. Am. Acad. Dermatol. 88, 40–51 (2023).
Article CAS PubMed Google Scholar
Mease, P. J. et al. Efficacy and safety of selective TYK2 inhibitor, deucravacitinib, in a phase II trial in psoriatic arthritis. Ann. Rheum. Dis. 81, 815–822 (2022).
Article CAS PubMed Google Scholar
Felson, D. T. et al. American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheumatol. 38, 727–735 (1995).
Furie, R. A. et al. Novel evidence-based systemic lupus erythematosus responder index. Arthritis Rheumatol. 61, 1143–1151 (2009).
Morand, E. et al. Deucravacitinib, a tyrosine kinase 2 inhibitor, in systemic lupus erythematosus: a phase II, randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol. 75, 242–252 (2023).
Article CAS PubMed Google Scholar
Connelly, K., Golder, V., Kandane-Rathnayake, R. & Morand, E. F. Clinician-reported outcome measures in lupus trials: a problem worth solving. Lancet Rheumatol. 3, e595–e603 (2021).
Article CAS PubMed Google Scholar
Wu, C. et al. Pharmacodynamic changes in SLE relevant gene expression induced by deucravacitinib in patients enrolled in the phase 2. Arthritis Rheumatol. 75
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