A Novel SIK2 Inhibitor SIC-19 exhibits Synthetic Lethality with PARP inhibitors in Ovarian Cancer
AbbreviationsSIK2
Salt-Inducible Kinase 2
SIC-19
SIK2-inhibiting compound 19
HRD
homologous recombination deficiency
HRP
homologous recombination proficiency
MOE
Molecular Operating Environment
CADD
Computer-aided drug design
DSB
DNA double-strand break
MMS
Methyl Methane Sulfonate
PARP
poly-ADP ribose polymerase
Keywords
Ovarian cancer SIK2 SIC-19 RAD50 PARP inhibitor
© 2024 The Authors. Published by Elsevier Ltd.
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