GBD 2017 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018;392:1859–922.

Article  PubMed Central  Google Scholar 

Kopchick JJ, Basu R, Berryman DE, Jorgensen JOL, Johannsson G, Puri V. Covert actions of growth hormone: fibrosis, cardiovascular diseases and cancer. Nat Rev Endocrinol. 2022;18:558–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banchs J, Lech T. Cardiovascular phenotypes and incident cardiovascular events in people with previous cancer. Heart 2023;109:974–6.

Article  PubMed  Google Scholar 

Adrover JM, McDowell SAC, He XY, Quail DF, Egeblad M. NETworking with cancer: the bidirectional interplay between cancer and neutrophil extracellular traps. Cancer Cell. 2023;41:505–26.

Article  CAS  PubMed  Google Scholar 

Wigerblad G, Kaplan MJ. Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases. Nat Rev Immunol. 2023;23:274–88.

Article  CAS  PubMed  Google Scholar 

Yan MN, Gu YF, Sun HX, Ge QH. Neutrophil extracellular traps in tumor progression and immunotherapy. Front Immunol. 2023;14:1135086.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shirakawa K, Sano M. Neutrophils and neutrophil extracellular traps in cardiovascular disease: an overview and potential therapeutic approaches. Biomedicines 2022;10:1850.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun S, Zou XY, Wang D, Liu YG, Zhang ZM, Guo JC, et al. IRGM/Irgm1 deficiency inhibits neutrophil-platelet interactions and thrombosis in experimental atherosclerosis and arterial injury. Biomed Pharmacother. 2023;158:114152.

Article  CAS  PubMed  Google Scholar 

Singh P, Kumar N, Singh M, Kaur M, Singh G, Narang A, et al. Neutrophil extracellular traps and NLRP3 inflammasome: a disturbing Duo in atherosclerosis, inflammation and atherothrombosis. Vaccines (Basel). 2023;11:261.

Article  CAS  PubMed  Google Scholar 

Tatsukawa Y, Hsu WL, Yamada M, Cologne JB, Suzuki G, Yamamoto H, et al. White blood cell count, especially neutrophil count, as a predictor of hypertension in a Japanese population. Hypertens Res. 2008;31:1391–7.

Article  PubMed  Google Scholar 

Ramasamy R, Maqbool M, Mohamed AL, Noah RM. Elevated neutrophil respiratory burst activity in essential hypertensive patients. Cell Immunol. 2010;263:230–4.

Article  CAS  PubMed  Google Scholar 

Li JH, Tong DX, Song B, Xie FY, Zhang GX, Hao X, et al. Inflammatory cytokines induce neutrophil extracellular traps interaction with activated platelets and endothelial cells exacerbate coagulation in moderate and severe essential hypertension. J Hypertens. 2022;40:2219–29.

Article  CAS  PubMed  Google Scholar 

McCarthy CG, Wenceslau CF, Goulopoulou S, Ogbi S, Baban B, Sullivan JC, et al. Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats. Cardiovasc Res. 2015;107:119–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jackson MH, Collier A, Nicoll JJ, Mui r AL, Dawes J, Clarke BF, et al. Neutrophil count and activation in vascular disease. Scott Med J 1992;37:41–3.

Article  CAS  PubMed  Google Scholar 

El-Eshmawy MM, El-Adawy EH, Mousa AA, Zeidan AE, El-Baiomy AA, Abdel-Samie ER, et al. Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women. BMC Women’s Health. 2011;11:1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krishnan J, de la Visitación N, Hennen EM, Amarnath V, Harrison DG, Patrick DM. IsoLGs (Isolevuglandins) Drive Neutrophil Migration in Hypertension and Are Essential for the Formation of Neutrophil Extracellular Traps. Hypertension 2022;79:1644–55.

Article  CAS  PubMed  Google Scholar 

Hofbauer T, Scherz T, Müller J, Heidari H, Staier N, Panzenböck A, et al. Arterial hypertension enhances neutrophil extracellular trap formation via an angiotensin-II-dependent pathway. Atherosclerosis 2017;263:67–68.

Article  Google Scholar 

Fang XH, Ma L, Wang YF, Ren F, Yu YQ, Yuan ZW, et al. Neutrophil extracellular traps accelerate vascular smooth muscle cell proliferation via Akt/CDKN1b/TK1 accompanying with the occurrence of hypertension. J Hypertens. 2022;40:2045–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kodigepalli KM, Bonifati S, Tirumuru N, Wu L. SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis. Cell Cycle. 2018;17:1124–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang XM, Wang PW, Zhang RL, Watanabe I, Chang E, Vinayachandran V, et al. KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression. J Clin Invest. 2022;132:e147191.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chrysanthopoulou A, Gkaliagkousi E, Lazaridis A, Arelaki S, Pateinakis P, Ntinopoulou M, et al. Angiotensin II triggers release of neutrophil extracellular traps, linking thrombo-inflammation with essential hypertension. JCI Insight. 2021;6:e148668.

Article  PubMed  PubMed Central  Google Scholar 

Saku K, Yokota S, Nishikawa T, Kinugawa K. Interventional heart failure therapy: A new concept fighting against heart failure. J Cardiol. 2022;80:101–9.

Article  PubMed  Google Scholar 

Redfield MM, Borlaug BA. Heart failure with preserved ejection fraction: a review. JAMA 2023;329:827–38.

Article  PubMed  Google Scholar 

Vulesevic B, Lavoie SS, Neagoe PE, Dumas E, Räkel A, White M, et al. CRP induces NETosis in heart failure patients with or without diabetes. Immunohorizons. 2019;3:378–88.

Article  CAS  PubMed  Google Scholar 

Shafqat A, Abdul Rab S, Ammar O, Salameh SA, Alkhudairi A, Kashir J, et al. Emerging role of neutrophil extracellular traps in the complications of diabetes mellitus. Front Med (Lausanne). 2022;9:995993.

Article  PubMed  Google Scholar 

Zhang XL, Wang TY, Chen Z, Wang HW, Yin Y, Wang L, et al. HMGB1-promoted neutrophil extracellular traps contribute to cardiac diastolic dysfunction in mice. J Am Heart Assoc. 2022;11:e023800.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Charles E, Dumont BL, Bonneau S, Neagoe PE, Villeneuve L, Räkel A, et al. Angiopoietin 1 release from human neutrophils is independent from neutrophil extracellular traps (NETs). BMC Immunol. 2021;22:51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao YS, Cong M, Li JT, He D, Wu QY, Tian P, et al. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell. 2021;39:423–37.

Article  CAS  PubMed  Google Scholar 

Yang CH, Wang Z, Li LL, Zhang ZG, Jin XY, Wu P, et al. Aged neutrophils form mitochondria dependent vital NETs to promote breast cancer lung metastasis. J Immunother Cancer. 2021;9:e002875.

Article  PubMed  PubMed Central  Google Scholar 

Shi L, Yao HL, Liu Z, Xu M, Tsung A, Wang YM. Endogenous PAD4 in breast cancer cells mediates cancer extracellular chromatin network formation and promotes lung metastasis. Mol Cancer Res. 2020;18:735–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang LB, Liu Q, Zhang XQ, Liu XW, Zhou BX, Chen JN, et al. DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. Nature 2020;583:133–8.

Article  ADS  CAS  PubMed  Google Scholar 

Zhou JW, Yang YL, Gan TT, Li Y, Hu F, Hao NN, et al. Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps. Oncol Lett. 2019;18:181–8.

CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Liu F, Chen L, Fang C, Li SY, Yuan SK, et al. Neutrophil extracellular traps (NETs) promote non-small cell lung cancer metastasis by suppressing lncRNA MIR503HG to activate the NF-kB/NLRP3 inflammasome pathway. Front Immunol. 2022;13:867516.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Albrengues J, Shields MA, Ng D, Park CG, Ambrico A, Poindexter ME, et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science 2018;361:eaao4227.

Article  PubMed  PubMed Central  Google Scholar 

Yang CF, Sun WY, Cui W, Li XK, Yao JL, Jia XY, et al. Procoagulant role of neutrophil extracellular traps in patients with gastric cancer. Int J Clin Exp Pathol. 2015;8:14075–86.

CAS  PubMed