Alizadeh SR, Ebrahimzadeh MA (2022) Quercetin derivatives: drug design, development, and biological activities, a review. Eur J Med Chem 229:114068. https://doi.org/10.1016/j.ejmech.2021.114068

Article  CAS  PubMed  Google Scholar 

Amieva M, Peek RM Jr (2016) Pathobiology of Helicobacter pylori-Induced Gastric Cancer. Gastroenterology 150:64–78. https://doi.org/10.1053/j.gastro.2015.09.004

Article  CAS  PubMed  Google Scholar 

Calgarotto AK, Maso V, Junior GCF, Nowill AE, Filho PL, Vassallo J, Saad STO (2018) Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells. Sci Rep 8:3459. https://doi.org/10.1038/s41598-018-21516-5

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Cao QH, Liu F, Yang ZL, Fu XH, Yang ZH, Liu Q, Wang L, Wan XB, Fan XJ (2016) Prognostic value of autophagy related proteins ULK1, Beclin 1, ATG3, ATG5, ATG7, ATG9, ATG10, ATG12, LC3B and p62/SQSTM1 in gastric cancer. Am J Transl Res 8:3831–3847

CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Kang R, Kroemer G, Tang D (2021b) Broadening horizons: the role of ferroptosis in cancer. Nat Reviews Clin Oncol 18:280–296. https://doi.org/10.1038/s41571-020-00462-0

Article  CAS  Google Scholar 

Chen C, Wang D, Yu Y, Zhao T, Min N, Wu Y, Kang L, Zhao Y, Du L, Zhang M et al (2021a) Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI. Cell Death Dis 12:65. https://doi.org/10.1038/s41419-020-03362-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Li J, Kang R, Klionsky DJ, Tang D (2021c) Ferroptosis: machinery and regulation. Autophagy 17:2054–2081. https://doi.org/10.1080/15548627.2020.1810918

Article  CAS  PubMed  Google Scholar 

Chen Z, Ouyang C, Zhang H, Gu Y, Deng Y, Du C, Cui C, Li S, Wang W, Kong W et al (2022) Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy. Autophagy 18:2270–2287. https://doi.org/10.1080/15548627.2022.2026097

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chuang KC, Chang CR, Chang SH, Huang SW, Chuang SM, Li ZY, Wang ST, Kao JK, Chen YJ, Shieh JJ (2020) Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells. J Dermatol Sci 98:152–162. https://doi.org/10.1016/j.jdermsci.2020.03.009

Article  CAS  PubMed  Google Scholar 

Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navàs D (2021) Autophagy in the physiological endometrium and cancer. Autophagy 17:1077–1095. https://doi.org/10.1080/15548627.2020.1752548

Article  CAS  PubMed  Google Scholar 

Di Petrillo A, Orrù G, Fais A, Fantini MC (2022) Quercetin and its derivates as antiviral potentials: a comprehensive review. Phytother Res 36:266–278. https://doi.org/10.1002/ptr.7309

Article  CAS  PubMed  Google Scholar 

Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A et al (2017) ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol 13:91–98. https://doi.org/10.1038/nchembio.2239

Article  CAS  PubMed  Google Scholar 

Gao W, Wang X, Zhou Y, Wang X, Yu Y (2022) Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy. Signal Transduct Target Ther 7:196. https://doi.org/10.1038/s41392-022-01046-3

Article  PubMed  PubMed Central  Google Scholar 

Gao W, Wang Y, Wang R, Wang YH, Xu JW, He XJ (2022b) Antiproliferative piperidine alkaloids from giant taro (Alocasia macrorrhiza). Chin J Nat Med 20:541–550. https://doi.org/10.1016/s1875-5364(22)60165-1

Article  CAS  PubMed  Google Scholar 

Guerrini GP, Esposito G, Magistri P, Serra V, Guidetti C, Olivieri T, Catellani B, Assirati G, Ballarin R, Di Sandro S et al (2020) Robotic versus laparoscopic gastrectomy for gastric cancer: the largest meta-analysis. Int J Surg (London England) 82:210–228. https://doi.org/10.1016/j.ijsu.2020.07.053

Article  Google Scholar 

Han D, Jiang L, Gu X, Huang S, Pang J, Wu Y, Yin J, Wang J (2020) SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels. J Cell Physiol 235:8839–8851. https://doi.org/10.1002/jcp.29727

Article  CAS  PubMed  Google Scholar 

He L, Zhang N, Wang L, Du L, Li C, Li Y, Li X, Zhu X, Lu Q, Yin X (2021) Quercetin inhibits AQP1 translocation in high-glucose-cultured SRA01/04 cells through PI3K/Akt/mTOR pathway. Curr Mol Pharmacol 14:587–596. https://doi.org/10.2174/1874467213666200908120501

Article  CAS  PubMed  Google Scholar 

Hosseini A, Razavi BM, Banach M, Hosseinzadeh H (2021) Quercetin and metabolic syndrome: a review. Phytother Res 35:5352–5364. https://doi.org/10.1002/ptr.7144

Article  CAS  PubMed  Google Scholar 

Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22:266–282. https://doi.org/10.1038/s41580-020-00324-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karimi P, Islami F, Anandasabapathy S, Freedman ND, Kamangar F (2014) Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research. Cosponsored Am Soc Prev Oncol 23:700–713. https://doi.org/10.1158/1055-9965.epi-13-1057

Article  Google Scholar 

Kim TW, Lee HG (2021) Apigenin induces autophagy and cell death by targeting EZH2 under Hypoxia conditions in Gastric Cancer cells. Int J Mol Sci 22. https://doi.org/10.3390/ijms222413455

Kuwada K, Kuroda S, Kikuchi S, Yoshida R, Nishizaki M, Kagawa S, Fujiwara T (2019) Clinical impact of Sarcopenia on gastric Cancer. Anticancer Res 39:2241–2249. https://doi.org/10.21873/anticanres.13340

Article  PubMed  Google Scholar 

Lee YC, Chiang TH, Chou CK, Tu YK, Liao WC, Wu MS, Graham DY (2016) Association between Helicobacter pylori Eradication and Gastric Cancer incidence: a systematic review and Meta-analysis. Gastroenterology 150:1113–1124e1115. https://doi.org/10.1053/j.gastro.2016.01.028

Article  PubMed  Google Scholar 

Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin SH, Ajani JA, Xiao Q, Liao Z, Wang H et al (2020) The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Cell Res 30:146–162. https://doi.org/10.1038/s41422-019-0263-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lei G, Zhuang L, Gan B (2022) Targeting ferroptosis as a vulnerability in cancer. Nat Rev Cancer 22:381–396. https://doi.org/10.1038/s41568-022-00459-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Kuang F, Kroemer G, Klionsky DJ, Kang R, Tang D (2020a) Autophagy-dependent ferroptosis: Machinery and Regulation. Cell Chem Biology 27:420–435. https://doi.org/10.1016/j.chembiol.2020.02.005

Article  CAS  Google Scholar 

Liu JZ, Hu YL, Feng Y, Jiang Y, Guo YB, Liu YF, Chen X, Yang JL, Chen YY, Mao QS et al (2020b) BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer. J Exp Clin Cancer Res 39:123. https://doi.org/10.1186/s13046-020-01620-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Chen C, Han D, Zhou W, Cui Y, Tang X, Xiao C, Wang Y, Gao Y (2022) SLC7A11/GPX4 inactivation-mediated ferroptosis contributes to the pathogenesis of Triptolide-Induced Cardiotoxicity. Oxid Med Cell Longev 2022:3192607. https://doi.org/10.1155/2022/3192607

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mathew B, Chennakesavalu M, Sharma M, Torres LA, Stelman CR, Tran S, Patel R, Burg N, Salkovski M, Kadzielawa K et al (2021) Autophagy and post-ischemic conditioning in retinal ischemia. Autophagy 17:1479–1499. https://doi.org/10.1080/15548627.2020.1767371

Article  CAS  PubMed  Google Scholar 

Mi Y, Zhong L, Lu S, Hu P, Pan Y, Ma X, Yan B, Wei Z, Yang G (2022) Quercetin promotes cutaneous wound healing in mice through Wnt/β-catenin signaling pathway. J Ethnopharmacol 290:115066. https://doi.org/10.1016/j.jep.2022.115066

Article  CAS  PubMed  Google Scholar 

Mou Y, Wang J, Wu J, He D, Zhang C, Duan C, Li B (2019) Ferroptosis, a new form of cell death: opportunities and challenges in cancer. J Hematol Oncol 12:34. https://doi.org/10.1186/s13045-019-0720-y

Article  PubMed  PubMed Central  Google Scholar 

Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, Shimizu S (2009) Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature 461:654–658. https://doi.org/10.1038/nature08455

Article  ADS  PubMed  Google Scholar 

Niu B, Liao K, Zhou Y, Wen T, Quan G, Pan X, Wu C (2021) Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy. Biomaterials 277:121110. https://doi.org/10.1016/j.biomaterials.2021.121110

Article  CAS  PubMed