Massagué J, Obenauf AC. Metastatic colonization. Nature. 2016;529:298–306.

Article  ADS  PubMed  PubMed Central  Google Scholar 

Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med. 2004;351:781–91.

Article  CAS  PubMed  Google Scholar 

Lindsay CR, Faugeroux V, Michiels S, Pailler E, Facchinetti F, Ou D, et al. A prospective examination of circulating tumor cell profiles in non-small-cell lung cancer molecular subgroups. Ann Oncol. 2017;28:1523–31.

Article  CAS  PubMed  Google Scholar 

Lucci A, Hall CS, Lodhi AK, Bhattacharyya A, Anderson AE, Xiao L, et al. Circulating tumour cells in non-metastatic breast cancer: a prospective study. Lancet Oncol. 2012;13:688–95.

Article  PubMed  Google Scholar 

Bian J, Yan K, Liu N, Xu X. Correlations between circulating tumor cell phenotyping and 18F-fluorodeoxyglucose positron emission tomography uptake in non-small cell lung cancer. J Cancer Res Clin Oncol. 2020;146:2621–30.

Article  CAS  PubMed  Google Scholar 

Flatmark K, Borgen E, Nesland JM, Rasmussen H, Johannessen H-O, Bukholm I, et al. Disseminated tumour cells as a prognostic biomarker in colorectal cancer. Br J Cancer. 2011;104:1434–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bidard F-C, Michiels S, Riethdorf S, Mueller V, Esserman LJ, Lucci A, et al. Circulating tumor cells in breast cancer patients treated by neoadjuvant chemotherapy: a meta-analysis. J Natl Cancer Inst. 2018;110:560–7.

Article  PubMed  Google Scholar 

Su Z, Wang Z, Ni X, Duan J, Gao Y, Zhuo M, et al. Inferring the evolution and progression of small-cell lung cancer by single-cell sequencing of circulating tumor cells. Clin Cancer Res. 2019;25:5049–60.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Shiratsuchi H, Lin J, Chen G, Reddy RM, Azizi E, et al. Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model. Oncotarget. 2014;5:12383–97.

Article  PubMed  PubMed Central  Google Scholar 

Padillo-Ruiz J, Suarez G, Pereira S, Calero-Castro FJ, Tinoco J, Marin L, et al. Circulating tumor cells enumeration from the portal vein for risk stratification in early pancreatic cancer patients. Cancers (Basel). 2021;13:6153.

Article  CAS  PubMed  Google Scholar 

Reduzzi C, Di Cosimo S, Gerratana L, Motta R, Martinetti A, Vingiani A, et al. Circulating tumor cell clusters are frequently detected in women with early-stage breast cancer. Cancers (Basel). 2021;13:2356.

Article  CAS  PubMed  Google Scholar 

Murlidhar V, Reddy RM, Fouladdel S, Zhao L, Ishikawa MK, Grabauskiene S, et al. Poor prognosis indicated by venous circulating tumor cell clusters in early-stage lung cancers. Cancer Res. 2017;77:5194–206.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu S-H, Tsai W-S, Chang Y-H, Chou T-Y, Pang S-T, Lin P-H, et al. Identifying cancer origin using circulating tumor cells. Cancer Biol Ther. 2016;17:430–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park JH, Pyun WY, Park HW. Cancer metabolism: phenotype. Signal Therap Targets Cells. 2020;9:2308.

CAS  Google Scholar 

Annabi B, Rojas-Sutterlin S, Laflamme C, Lachambre M-P, Rolland Y, Sartelet H, et al. Tumor Environment Dictates Medulloblastoma Cancer Stem Cell Expression and Invasive Phenotype. Mol Cancer Res. 2008;6:907–16.

Article  CAS  PubMed  Google Scholar 

Lawrence MS, Stojanov P, Mermel CH, Garraway LA, Golub TR, Meyerson M, et al. Discovery and saturation analysis of cancer genes across 21 tumor types. Nature. 2014;505:495–501.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Lee J-K, Choi Y-L, Kwon M, Park PJ. Mechanisms and consequences of cancer genome instability: lessons from genome sequencing studies. Annu Rev Pathol. 2016;11:283–312.

Article  CAS  PubMed  Google Scholar 

Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature. 1998;396:643–9.

Article  ADS  CAS  PubMed  Google Scholar 

Taron M, Ichinose Y, Rosell R, Mok T, Massuti B, Zamora L, et al. Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. Clin Cancer Res. 2005;11:5878–85.

Article  CAS  PubMed  Google Scholar 

Chou T-Y, Chiu C-H, Li L-H, Hsiao C-Y, Tzen C-Y, Chang K-T, et al. Mutation in the tyrosine kinase domain of epidermal growth factor receptor is a predictive and prognostic factor for gefitinib treatment in patients with non-small cell lung cancer. Clin Cancer Res. 2005;11:3750–7.

Article  CAS  PubMed  Google Scholar 

Concin N, Hofstetter G, Berger A, Gehmacher A, Reimer D, Watrowski R, et al. Clinical relevance of dominant-negative p73 isoforms for responsiveness to chemotherapy and survival in ovarian cancer: evidence for a crucial p53–p73 cross-talk in vivo. Clin Cancer Res. 2005;11:8372–83.

Article  CAS  PubMed  Google Scholar 

Wang J, Yao Z, Jonsson P, Allen AN, Qin ACR, Uddin S, et al. A secondary mutation in BRAF confers resistance to RAF inhibition in a BRAF V600E-mutant brain tumor. Cancer Discov. 2018;8:1130–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Z, Zhang Q, Qi C, Bai Y, Zhao F, Chen H, et al. Combination of AKT1 and CDH1 mutations predicts primary resistance to immunotherapy in dMMR/MSI-H gastrointestinal cancer. J Immunother Cancer. 2022;10: e004703.

Article  PubMed  PubMed Central  Google Scholar 

Hu J, Cao J, Topatana W, Juengpanich S, Li S, Zhang B, et al. Targeting mutant p53 for cancer therapy: direct and indirect strategies. J Hematol Oncol. 2021;14:157.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sicklick JK, Kato S, Okamura R, Schwaederle M, Hahn ME, Williams CB, et al. Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study. Nat Med. 2019;25:744–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morganti S, Tarantino P, Ferraro E, D’Amico P, Viale G, Trapani D, et al. Complexity of genome sequencing and reporting: Next generation sequencing (NGS) technologies and implementation of precision medicine in real life. Crit Rev Oncol Hematol. 2019;133:171–82.

Article  PubMed  Google Scholar 

Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA, Kinzler KW. Cancer genome landscapes. Science. 2013;339:1546–58.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Yates LR, Knappskog S, Wedge D, Farmery JHR, Gonzalez S, Martincorena I, et al. Genomic evolution of breast cancer metastasis and relapse. Cancer Cell. 2017;32:169-184.e7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paoletti C, Cani AK, Larios JM, Hovelson DH, Aung K, Darga EP, et al. Comprehensive mutation and copy number profiling in archived circulating breast cancer tumor cells documents heterogeneous resistance mechanisms. Cancer Res. 2018;78:1110–22.

Article  CAS  PubMed  Google Scholar 

Kulemann B, Rösch S, Seifert S, Timme S, Bronsert P, Seifert G, et al. Pancreatic cancer: circulating tumor cells and primary tumors show heterogeneous KRAS mutations. Sci Rep. 2017;7:4510.

Article  ADS  PubMed  PubMed Central  Google Scholar 

Magbanua MJM, Rugo HS, Wolf DM, Hauranieh L, Roy R, Pendyala P, et al. Expanded genomic profiling of circulating tumor cells in metastatic breast cancer patients to assess biomarker status and biology over time (CALGB 40502 and CALGB 40503, Alliance). Clin Cancer Res. 2018;24:1486–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gasch C, Bauernhofer T, Pichler M, Langer-Freitag S, Reeh M, Seifert AM, et al. Heterogeneity of epidermal growth factor receptor status and mutations of KRAS/PIK3CA in circulating tumor cells of patients with colorectal cancer. Clin Chem. 2013;59:252–60.

Article  CAS  PubMed  Google Scholar 

Owen S, Lo T-W, Fouladdel S, Zeinali M, Keller E, Azizi E, et al. Simultaneous single cell gene expression and EGFR mutation analysis of circulating tumor cells reveals distinct phenotypes in NSCLC. Adv Biosyst. 2020;4: e2000110.

Article  PubMed  PubMed Central  Google Scholar 

De Luca F, Rotunno G, Salvianti F, Galardi F, Pestrin M, Gabellini S, et al. Mutational analysis of single circulating tumor cells by next generation sequencing in metastatic breast cancer. Oncotarget. 2016;7:26107–19.

Article  PubMed