Concentrations of Fluoxetine Enantiomers Decline During Pregnancy and Increase After Birth

From the 1Developing Brain Institute, Children's National Hospital, Washington, DC

Departments of 2Obstetrics and Gynecology

3Anesthesiology

4Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL

5AY Analytics, Westmont, IL

6Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Magee Women's Hospital, Pittsburgh, PA

7Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, OH.

Received August 22, 2023; accepted after revision December 4, 2023.

This study, Optimizing Medication Management for Mothers with Depression (OPTIMOM, NICHD 1U54HD085601‐01, Clinical Trials.gov ID NCT02519790, PIs: KL Wisner, C Stika, A George), was supported by The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [U54HD047891, U54HD047905, and U54HD085601].

This work was conducted when K.L.W. was at Northwestern University Feinberg School of Medicine.

A.Y. renders contractual statistical service to Northwestern University Feinberg School of Medicine.

Address correspondence to: Katherine L. Wisner, MD, MS, Developing Brain Institute, Children's National Hospital, 111 Michigan Ave NW, Washington, DC 20001 (e-mail: [email protected]).

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