Vacuum gas oil (VGO) is a hydrocarbon combination formed during crude oil extraction, and its consumption may have neurological repercussions. This study investigated the neuroprotective properties of Monodora myristica and Glycyrrhiza glabra in rats given cassava flour diet containing vacuum gas oil (CFD-VGO). Thirty rats were separated into six groups and treated as follows: Group 1 severed as normal control. Group 2 were fed CFD-VGO only. After a normal diet was given to groups 3, 4, and 5, M. myristica, G. glabra, and M. myristica plus G. glabra extracts were administered. Group 6, 7, 8 and 9 were given CFD-VGO and then treated with M. myristica extract, G. glabra extract, M. myristica plus G. glabra extracts and 2-methyl cellulose respectively. The rats were euthanized using carbon dioxide after experimental period of 28 days. The brain was excised for biochemical assays. The results showed that the concentration of the assessed 16 PAHs in CFD-VGO using GC-MS was 53.38 ppm. Significant (p < 0.05) increase were observed in malondialdehyde (MDA), total cholesterol (T.Chl), triacylglycerol (TAG), low density lipoprotein-cholesterol (LDL-C), and decrease in high density lipoprotein-cholesterol (HDL-C), acetylcholinesterase (AChE) and ATPases in the brain rats fed with CFD-VGO. On the other hand, administration of M. myristica and G. glabra extract effectively restored altered antioxidants, ATPases, and lipids in brain of rats fed with cassava diet containing VGO.